重庆市关于建设职业化食品药品检查员队伍的探索

目的探索职业化食品药品检查员队伍建设的方法途径,为提升重庆市食品药品监管提供对策。方法通过整合职能职责、改变机构性质、调整检查员队伍结构、引入系统外专家检查员、加强检查员培训、完善管理制度等措施推迚职业化检查员队伍建设。结果重庆市建立和完善了检查员管理、检查工作开展等相兲制度,检查队伍知识水平、专业素质、业务能力得到改善,机构履职能力得到提高,职业化检查员队伍能够为监管部门提供技术支撑,也能够促迚产业发展。但在法律定位、顶层设计、专职队伍建设、分级分类管理等方面存在尚需解决的问题。结论职业化检查员队伍建设可以弥补我国食品药品监管人员少、任务重、专业性不足的问题,但深入推行职业化检查员制度还需从国家层面解决法律定位、队伍建设方向等问题。     

Identification and analysis of circRNA–miRNA–mRNA regulatory network in hepatocellular carcinoma

This study was to identify important circRNA–miRNA–mRNA (ceRNAs) regulatory mechanisms in hepatocellular carcinoma (HCC). The circRNA dataset {"type":"entrez-geo","attrs":{"text":"GSE97332","term_id":"97332"}}GSE97332 and miRNA dataset {"type":"entrez-geo","attrs":{"text":"GSE57555","term_id":"57555"}}GSE57555 were used for analyses. Functional enrichment analysis for miRNA and target gene was conducted using cluster Profiler. Survival analysis was conducted through R package Survival. The ceRNAs and drug–gene interaction networks were constructed. The ceRNAs network contained five miRNAs including hsa‐miR‐25‐3p, hsa‐miR‐3692‐5p, hsa‐miR‐4270, hsa‐miR‐331‐3p, and hsa‐miR‐125a‐3p. Among the network, hsa‐miR‐25‐3p targeted the most genes, hsa‐miR‐3692‐5p and hsa‐miR‐4270 were targeted by more circRNAs than other miRNAs, hsa‐circ‐0034326 and hsa‐circ‐0011950 interacted with three miRNAs. Furthermore, target genes, including NRAS, ITGA5, SLC7A1, SEC14L2, SLC12A5, and SMAD2 were obtained in drug–gene interaction network. Survival analysis showed NRAS, ITGA5, SLC7A1, SEC14L2, SLC12A5, and SMAD2 were significantly associated with prognosis of HCC. NRAS, ITGA5, and SMAD2 were significantly enriched in proteoglycans in cancer. Moreover, hsa‐circ‐0034326 and hsa‐circ‐0011950 might function as ceRNAs to play key roles in HCC. Furthermore, miR‐25‐3p, miR‐3692‐5p, and miR‐4270 might be significant for HCC development. NRAS, ITGA5, SEC14L2, SLC12A5, and SMAD2 might be prognostic factors for HCC patients via proteoglycans in cancer pathway. Taken together, the findings will provide novel insight into pathogenesis, selection of therapeutic targets and prognostic factors for HCC.Inspec keywords: cancer, cellular biophysics, patient diagnosis, bioinformatics, tumours, biochemistry, molecular biophysics, genetics, drugs, RNAOther keywords: ITGA5, SMAD2, hsa‐circ‐0034326, SEC14L2, SLC12A5, target gene, survival analysis, drug–gene interaction network, miRNAs, hsa‐miR‐25‐3p, hsa‐miR‐3692‐5p, hsa‐miR‐4270, hsa‐miR‐331‐3p, hsa‐miR‐125a‐3p, hsa‐circ‐0011950, SLC7A1, pathogenesis, therapeutic targets, prognostic factors, circRNA‐miRNA‐mRNA regulatory network, current 125.0 A     

模糊数学方法研制麦麸悬浮饮料

目的利用麦麸中阿魏酸等活性成分研制一款全麦麸食品。方法采用均匀试验设计原理,结合模糊数学综合分析法,探讨出一种麦麸悬浮饮料的最佳配方比例。结果白砂糖添加量为3.5g/100mL、麦麸:水为1:100(g:mL)、复合稳定剂添加量为0.08g/100mL、黄原胶:魔芋胶为7:3(m:m)为麦麸悬浮饮料最佳配方比例。产品中膳食纤维总量为0.872 g/100 mL,黄酮含量为0.92 mg/100 mL,阿魏酸含量为2.81 mg/100 mL,二苯基苦酰肼基自由基清除率达到63.9%。结论制备的麦麸悬浮饮料口感顺滑,具有浓郁麦香味,麦麸颗粒能够均匀稳定悬浮。     

可生物降解的化妆品包装材料研究进展

目的 综述可生物降解的包装材料在化妆品应用方面的研究进展,为生物降解材料的广泛使用提供参考。方法 通过对国内外聚乳酸、聚羟基链烷酸酯、纤维素、壳聚糖等可生物降解包装材料在化妆品中的研究与应用,分析各种材料的性能特点,提出可生物降解的包装材料在化妆品应用方面的未来展望。结果 不同类型的化妆品应根据产品特性选择适宜的可生物降解的包装材料,可生物降解包装材料在化妆品中的应用有待进一步研究和推广。结论 可生物降解材料应用于化妆品包装是未来发展趋势之一,应用纳米技术对材料性能提升具有重要意义。     

飞行检查在重庆市食品生产经营企业检查中的应用案例剖析

目的探索飞行检查方式在食品生产经营企业检查中应用的可行性。方法利用飞行检查方式对282家食品生产经营企业开展检查,对开展情况进行汇总、梳理、对比分析。结果飞行检查与许可检查和日常检查相比,具有显著的优点,能够起到很好的互补作用。结论飞行检查运用于食品生产经营企业检查,可有效弥补许可检查和日常检查的不足之处,食品安全监管引入飞行检查方式能深入排查食品生产经营企业存在的质量安全风险,帮助企业主动提升履行主体责任的意识。