两种冠醚环化二硫纶配体的Ni配合物的合成、结构及光电性质研究

以配体Ia、Ib和Ni(dbbpy)Cl_2(dbbpy=4,4′-二-叔丁基-2,2′-联吡啶)反应,合成了两种新型冠醚环化二硫纶配体的Ni(Ⅱ)配合物1和2。经~1 H NMR、IR、MS和元素分析表征了二者的结构,并解析了其晶体结构,初步测定了其光电响应性质。结果表明,配合物2对Li~+有较明显的响应,ΔE_1~(1/2)=35mV(30倍Li~+),对碱金属离子Na~+和K~+均无明显响应。同时配合物1和2在室温下均有明显的溶剂变色现象。     

新型异金属三羰基铼配合物的合成及光学性质研究

将双吡啶基多硫桥式配体(Ⅲ)依次与Ni(dbbpy)Cl2(dbbpy=4,4′-二叔丁基-2,2′-联吡啶)、Re(CO)_5Cl反应,合成了一个新型的双核卤化三羰基一价铼异金属配合物(2)及其前体配合物(1)。采用~1H NMR、IR、MS和元素分析表征1和2的结构,并解析了二者的晶体结构,初步测定了其光学性质。结果表明,配合物1和2的CH_2Cl_2溶液在250~305nm附近有很强的吸收带,摩尔消光系数级数为104,但未观测到二者发射荧光。最后在密度泛函(DFT)水平上研究了配合物1和2的基态轨道能量。     

Mechanism of enhanced oral absorption of akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex

Akebia saponin D (ASD) exhibits a variety of pharmacological activities, such as anti-osteoporosis, neuroprotection, hepatoprotection, but has poor oral bioavailability. A self-nanoemulsifying drug delivery system loaded with akebia saponin D - phospholipid complex (APC-SNEDDS) (composition: Peceol: Cremophor^® EL: Transcutol HP: ASD: phospholipid; ratio: 10:45:45:51:12.3, w:w:w:w:w) was first developed to improve the oral absorption of saponins and it was found to significantly enhance ASD’s oral bioavailability by 4.3 - fold (p?<?.01). This study was conducted to elucidate the mechanism of enhanced oral absorption of ASD by the drug delivery system of APC-SNEDDS. The aggregation morphology and particle size of ASD and APC-SNEDDS prepared in aqueous solutions were determined by transmission electron microscope and particle size analyzer, respectively. Stability of ASD and APC-SNEDDS in gastrointestinal luminal contents and mucosa homogenates were also explored. The differences of in situ intestinal permeability of ASD and APC-SNEDDS were compared. APC-SNEDDS reduced the aggregation size from 389?±?7?nm (ASD) to 148?±?3?nm (APC-SNEDDS). APC-SNEDDS increased the remaining drug in large intestine luminal contents from 47?±?1% (ASD) to 83?±?1% (APC-SNEDDS) during 4?h incubation. APC-SNEDDS provided an 11-fold increase in Ka value and an 11-fold increase in P_eff value compared to ASD. In summary, APC-SNEDDS improved ASD’s oral bioavailability mainly by increasing membrane permeability, destroying self-micelles and inhibiting the intestinal metabolism.     

扬州稀甜酱中乳酸菌的分离鉴定及抑菌活性初探

以扬州稀甜酱为研究对象,采用经典乳酸菌筛选法从样品中分离、纯化乳酸菌,采用形态学观察、生理生化试验和16S rRNA序列分析对乳酸菌进行鉴定,并采用牛津杯法对发酵滤液的抑菌活性进行研究。结果表明,从扬州稀甜酱中共分离、纯化出33株乳酸菌,其中15株菌株被鉴定为屎肠球菌（Enterococcus faecium）,12株菌株被鉴定为乳酸片球菌（Pediococcus acidilactici）,4株菌株被鉴定为类肠膜魏斯氏菌（Weissella paramesenteroides）,2株菌株被鉴定为酸鱼乳杆菌（Lactobacillus acidipiscis）,屎肠球菌和乳酸片球菌为扬州稀甜酱中的优势乳酸菌。乳酸片球菌TJ17和TJ31发酵滤液对金黄色葡萄球菌（Staphylococcus aureus）、单核细胞增生李斯特氏菌（Listeria monocytogenes）和大肠埃希氏菌（Escherichia coli）均有明显的抑制作用,且乳酸片球菌TJ31抑菌效果较好。     

Synergistic effect of microwave 3D print and transglutaminase on the self-gelation of surimi during printing

To improve the molding quality of 3D printed surimi products under the disturbance of self-gravity and post-processing, the synergistic effect of a microwave 3D print (MW3DP) and transglutaminase (TGase) on the self-gelation process of surimi from fluid to solid gel state during 3D printing is investigated. Simulation and 3D printing results show that microwave power affected the extrudability by changing the temperature distribution of surimi in the nozzle. Rheological properties of the squeezed-out surimi were monitored while the gel properties, microstructure and self-gelation mechanism of products after printing were analyzed. Surimi exhibited shear-thinning behavior when microwave power was less than 60 W/g. After printing, the solid gels with better shape fidelity and large protein aggregates appeared at 40 and 50 W/g when TGase was added. Results indicate that hydrogen bonds and ɛ-(γ-Glu)-Lys are main forces to maintain molding quality, and TGase is activated by microwaves to promote the self-gelation process.Industrial relevance3D food printing, as an emerging technology in food industry, has great potential in meeting the individual needs of consumers for shapes and nutrition. One of the challenges that restricts the large-scale industrialization and commercialization of 3D food printing is that deformation will occur during printing and subsequent processing because most food materials are still flowing after printing. This study provided a synergistic method of MW3DP with a focused heating mode and TGase, realizing self-gelation of surimi during printing. A solid product with high resistance to deformation was obtained in this condition. Valuable guidance is provided to obtain heat-induced solid products with better shape fidelity. In addition, a more complex hollow shape can be printed to improve the personalization of food manufacturing, thus promoting further applications of 3D printing in food industry.     

高效液相色谱法快速测定乳粉中的三聚氰胺与双氰胺

建立高效液相色谱-二极管阵列检测器同时检测乳粉中三聚氰胺和双氰胺的分析方法。采用1%三氯乙酸溶液提取样品中的三聚氰胺和双氰胺,氨基柱为分析柱,流动相为乙腈-水（75∶25,V/V）,流速1.0 mL/min,检测波长233 nm。2 种物质在0.005～60 mg/L范围内与其峰面积线性关系良好,不同添加水平的回收率在83.2%～102.6%,三聚氰胺和双氰胺的方法定量限分别为0.17、0.15 mg/kg,方法变异系数为2.3%～7.2%（n=6）。此方法操作简便、快速、成本低,适用于乳粉中三聚氰胺和双氰胺的同时检测。     

扬州酱菜中降解亚硝酸盐乳酸菌的筛选、鉴定及性能研究

以扬州地区传统酱菜为研究对象,采用离子色谱（IC）法从32株乳酸菌中筛选降解亚硝酸盐能力较强的乳酸菌菌株,采用形态观察、生理生化试验和16S rDNA序列分析对其进行鉴定,并对其生长性能进行测定。结果表明,从扬州地区传统酱菜中筛选出一株降解亚硝酸盐能力较强的乳酸菌菌株,编号为DGJ-17,其亚硝酸盐降解率为91.7%;菌株DGJ-17被鉴定为乳酸肠球菌（Enterococcus lactis）;菌株DGJ-17的最适生长温度为30 ℃,培养12 h后进入对数生长期,30 h后细胞生物量趋于稳定。     

Metal organic framework (MOF) in aqueous energy devices

Aqueous energy devices are under the spotlight of current research due to their safety, low cost and ease of handling. Metal-organic frameworks (MOFs) and their derivatives have spurred extensive exploration as they provide a library of new electrode materials. The rich and structural flexibilities (such as metal nodes, ligands, pore structure) endow MOFs and MOFs-derivatives with vast opportunities for various energy devices. In this review, we discuss the correlation between MOF structural parameters and electrochemical performance for aqueous energy devices in the scope of zinc-based batteries (Zn-ion, Zn-alkaline and Zn-air batteries), potassium-ion batteries and supercapacitors. For each energy device, the effect of determinative factors and structural modulating strategies of MOFs and derivatives are highlighted. Finally, we summarize the challenges and provide our perspective about MOFs and derivatives for future aqueous energy devices.