Clinical Characteristics and Outcomes of Type 2 Diabetes Patients Infected with COVID-19: A Retrospective Study

Diabetes and its related metabolic disorders have been reported as the leading comorbidities in patients with coronavirus disease 2019 (COVID-19). This clinical study aims to investigate the clinical features, radiographic and laboratory tests, complications, treatments, and clinical outcomes in COVID-19 patients with or without diabetes. This retrospective study included 208 hospitalized patients (≥ 45 years old) with laboratory-confirmed COVID-19 during the period between 12 January and 25 March 2020. Information from the medical record, including clinical features, radiographic and laboratory tests, complications, treatments, and clinical outcomes, were extracted for the analysis. 96 (46.2%) patients had comorbidity with type 2 diabetes. In COVID-19 patients with type 2 diabetes, the coexistence of hypertension (58.3% vs 31.2%), coronary heart disease (17.1% vs 8.0%), and chronic kidney diseases (6.2% vs 0%) was significantly higher than in COVID-19 patients without type 2 diabetes. The frequency and degree of abnormalities in computed tomography (CT) chest scans in COVID-19 patients with type 2 diabetes were markedly increased, including ground-glass opacity (85.6% vs 64.9%, P < 0.001) and bilateral patchy shadowing (76.7% vs 37.8%, P < 0.001). In addition, the levels of blood glucose (7.23 mmol·L⁻¹ (interquartile range (IQR): 5.80–9.29) vs 5.46 mmol·L⁻¹ (IQR: 5.00–6.46)), blood low-density lipoprotein cholesterol (LDL-C) (2.21 mmol·L⁻¹ (IQR: 1.67–2.76) vs 1.75 mmol·L⁻¹ (IQR: 1.27–2.01)), and systolic pressure (130 mmHg (IQR: 120–142) vs 122 mmHg (IQR: 110–137)) (1 mmHg = 133.3 Pa) in COVID-19 patients with diabetes were significantly higher than in patients without diabetes (P < 0.001). The coexistence of type 2 diabetes and other metabolic disorders is common in patients with COVID-19, which may potentiate the morbidity and aggravate COVID-19 progression. Optimal management of the metabolic hemostasis of glucose and lipids is the key to ensuring better clinical outcomes. Increased clinical vigilance is warranted for COVID-19 patients with diabetes and other metabolic diseases that are fundamental and chronic conditions.     

代谢网络可视化系统的力导向布局算法设计

针对生物化学代谢反应网络可视化系统的优化设计,提出了一个基于力导向模型的解决方案。新方案根据具体的可视化目标,综合拓扑信息进行参数调整。实验表明,这些调整给可视化的布局质量带来很大的改善。另外,代谢网络具有鲜明的无尺度网络特性。据此,进一步提出了针对枢纽结点的优化方案,在视觉效果上突出了代谢反应网络的无尺度特性。为了融合力导向方案和基于无尺度网络特性的局部调整方案,最后总结了一个三阶段的布局算法框架。     

银耳多糖超声波提取工艺优化及抗BV2细胞炎症的作用研究

以银耳为原料, 采用超声波辅助热水浸提法提取银耳多糖, 以多糖提取率为指标, 以超声波功率、提取料液比、提取温度和提取时间为影响因素, 设计单因素试验, 并通过正交试验得到较佳提取工艺。通过用TRPV1(Transient Receptor Potential Vanilloid1)试剂盒检测了小胶质细胞TRPV1的释放水平, 与脂多糖(Lipopolysaccharide, LPS)对照组相比, 不同质量浓度的银耳多糖组(62.5, 250, 1000 μg/mL)均能不同程度地抑制TRPV1的释放量。说明了银耳多糖对于BV2小胶质细胞炎症具有良好的抑制作用。     

An intelligent stock trading system using comprehensive features

The aim of this study is to predict automatic trading decisions in stock markets. Comprehensive features (CF) for predicting future trend are very difficult to generate in a complex environment, especially in stock markets. According to related work, the relevant stock information can help investors formulate objects that may result in better profits. With this in mind, we present a framework of an intelligent stock trading system using comprehensive features (ISTSCF) to predict future stock trading decisions. The ISTSCF consists of stock information extraction, prediction model learning and stock trading decision. We apply three different methods to generate comprehensive features, including sentiment analysis (SA) that provides sensitive market events from stock news articles for sentiment indices (SI), technical analysis (TA) that yields effective trading rules based on trading information on the stock exchange for technical indices (TI), as well as the trend-based segmentation method (TBSM) that raises trading decisions from stock price for trading signals (TS). Experiments on the Taiwan stock market show that the results of employing comprehensive features are significantly better than traditional methods using numeric features alone (without textual sentiment features).     

云计算给教育信息化带来的变化

在过去几年里,云计算和虚拟化的概念获得了巨大的发展动力,并且成为信息技术中的流行词。许多企业开始实现这些新技术,期望通过改进机器的利用率来降低成本,减少管理时间和基础设施成本,教育机构或院校也迫切需要通过实施虚拟化和云计算提高业务扩展的敏捷性,降低业务快速扩展时产生的风险和重复投资,同时降低运营成本,可以说,云计算平台的实施对于教育行业的影响重要而深远。     

卡尔曼滤波语音增强算法的CUDA实现

提出一种卡尔曼滤波语音增强算法的统一计算设备架构并行实现方案。该方案通过离散余弦变换把含噪语音分解为不相关的DCT系数,使原来的时域串行处理转化为统一计算设备架构并行处理,只需较少的线性预测阶数,节省运算时间。实验结果表明:与时域卡尔曼滤波比较,该方法有更高的输出分段信噪比,其统一计算设备架构加速方案可有效缩短语音增强运算的时间。     

基于Java反射机制的POI实现Excel数据导入/导出

随着Java语言越来越多地被选择用于B/S结构系统的开发语言,利用POI解析技术操作Excel文件越来越广泛。在POI组件下,采用Java反射机制及自定义注解原理,设计实现了数据库与Excel文件的数据交互。此方法不仅能保证数据导入的完整性,而且能免去数据导出后重新编辑的复杂性,从而提高POI实现Excel数据导入/导出的灵活性、重用性和易扩展性。