山药

山药是一种常用的中药，营养丰富，具有较高的药疗价值，现对山药的化学成分、药理作用、临床应用的研究进展作一介绍。     

光纤SPR传感器在抗感染中药作用机理的应用

提出一种基于光纤表面等离子体共振（SPR）传感器的检测法,检测抗感染中药与细胞因子和受体间的相互作用.采用真空热蒸镀法镀双层金属膜制作一种双金属光纤SPR生物传感器,应用直接法完成中药作用机理检测.该传感器具有快速、客观、准确、高效的中药作用机理检测功能,获得了相应数据.光纤SPR生物传感器的应用使得中药作用机理过程的检测具有实时高效的优点,有望在抗感染中药作用的靶点和分子机理研究中取得新的突破.     

1-氯甲基磺酰胺类化合物的合成

以吡啶为催化剂,实现了氯甲基磺酰氯和芳香伯胺的磺酰化反应。考察了催化剂、溶剂、物料比、反应温度等条件对反应产率的影响。结果表明,最优反应条件为:n(胺)∶n(磺酰氯)=1∶1.3,吡啶为催化剂,二氯甲烷为溶剂,先0℃再室温下反应,反应时间为4～8h。在最优条件下,以42%～95%的产率合成了9种具有不同取代基的磺酰胺类化合物。利用IR、~1HNMR、~(13)CNMR对目标产物的结构进行了确证。     

课外科技活动与大学生创新能力的培养

高等学校是培养创新人才的基地和摇篮,肩负着重要的历史使命。必须全方位更新观念,把培养大学生的创新能力作为教育改革的核心。而开展大学生课外科技活动,是激发学生创新意识、提高学生综合素质的重要手段,有利于营造浓厚的科技氛围,促使学生理论联系实际,培养实践能力,激发创新能力。     

基于无线网络与二维码的医院高值耗材管理与追溯系统研究--以江西某三甲医院为例

本系统通过条码技术建立各个环节的逻辑关系,无线网络和移动计算技术的应用解决了耗材信息采集的问题,与医院信息系统实现对接,实现高值耗材追溯管理。系统对高值耗材的入库、出库、移动、盘点等操作进行全面的控制和管理,达到降低库存、减少资金占用的目的,实现医院库房管理的自动化。     

医师科技创新能力评价指标构建

本文运用文献分析法、Delphi法和层次分析法筛选和确定了医师科技创新能力指标体系。该评价体系包括专业教育背景、知识创新能力、技术创新能力和学术交流能力4项一级指标,11项二级指标,部分二级指标又细分为三级指标,对每一指标给出相应权重系数和内涵,并对各项指标提出量化方法。     

STAT3及其肿瘤关系的研究进展

STAT3是一类具有信号转导和转录激活双重功能的蛋白,在人类多种癌症包括实体瘤、白血病、淋巴瘤、乳腺癌、胰腺癌、前列腺癌等多种癌症的发生发展中,都起到至关重要的调控作用。     

Ultrathin MoSSe alloy nanosheets anchored on carbon nanotubes as advanced catalysts for hydrogen evolution

The activity of transition metal dichalcogenides (TMD) toward hydrogen evolution reaction (HER) derives from the active sites at the edges, but the basal surface still remain catalytic insert. Herein, ultrathin MoSSe alloy nanosheets array on multiwalled carbon nanotubes (MWCNTs) to form a core shell structure via a simple solvothermal process. These three-dimensional (3D) MoSSe hybrids show a high activity in hydrogen evolution reaction (HER) with a small Tafel slope of 38 mV dec⁻¹ and a low overpotential of 102 mV at 10 mA cm⁻². In addition, their HER activity remains remarkably stable without significant decay after 100 h polarization. Such superior catalytic HER activity springs from the 3D hierarchical heterostructure, which is abundant of catalytic edge sites, and the alloy effect between S and Se, which will create huge defects and strain to form vacancy sites on the basal plane. This strategy may open a new avenue toward the development of nonprecious high-performance HER catalysts.     

PtIr alloy nanowire assembly on carbon cloth as advanced anode catalysts for methanol oxidation

The interconnecred PtIr alloy nanowires were uniformly deposited on carbon cloth via One-step wet chemistry method, which diameter is averaged to be 5 nm with a length of 50–200 nm. The carbon cloth supported PtIr nanowire assembly (PtIr NA/CC) shows a larger electrochemical active surface area (ECSA) due to its 3D nanostructure and a high CO-resistance as a result from the synergistic effect of PtIr alloy. The PtIr NA/CC exhibits an extremely high mass activity and a reliable long-term stability toward methanol oxidation reaction (MOR). The superior catalytic performance on MOR can match and even surpass those best Pt-based nanowires reported recently in the literature.     

ABTS+ scavenging potency of selected flavonols from Hypericum perforatum L. by HPLC-ESI/MS QQQ: Reaction observation,adduct characterization and scavenging activity determination

Hypericum perforatum L. (HPL) has been used as a beneficial herb on menopause related syndromes for many years due to its antioxidant activity by inhibiting lipid oxidation. The major bioactive gradients of HPL are flavonoids. To date, extensive researches have been focused on its antioxidant effects, however, their exact antioxidant properties remain unclear. For this purpose, this study monitored the antioxidant ability of four common and representative HPL flavonols (rutin, hyperoside, quercitrin and quercetin) to interfere with the reaction of 2, 2′-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) free radical (ABTS⁺) based on the kinetic spectrophotometric free radical processing measurement method. In addition, to characterize the antioxidant reaction paths, the above-mentioned products were identified by high performance liquid chromatography–electrospray ionization/mass spectrometer triple quad (HPLC–ESI/MS QQQ) analysis, which was superior to gas chromatography–mass spectrometer (GC–MS) in that no derivation resulted. After the adduct products were identified in the MS2 scan mode, a multiple reaction monitoring (MRM) based LC–MS method for the ABTS⁺ scavenging determination was developed and validated. The results of free radical scavenging kinetic evaluation showed that the ABTS⁺ scavenging process of the four flavonols was relatively slow and steady. The degradation products of reactions between flavonols and ABTS⁺ were mainly a combination of flavonols with the ABTS molecule by reducing 3-ethyl-6-benzothiazolinone imine. Flavonols substituted by glycosides tended to follow a RDA cleavage fragmentation path. With a good linearity regression coefficient (r² = 0.995) and a good accuracy of 96.5–106.2%, the free radical scavenging ability of rutin, hyperoside, quercitrin and quercetin was 19.0%, 36.1%, 40.2% and 39.5%, respectively. The kinetic scavenging features and specific fragment features deduced here of the four flavonols in vitro could shed light on HPL's antioxidant properties.