A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.     

An Exemplar Imidazoline Surfactant for Corrosion Inhibitor Studies: Synthesis,Characterization, and Physicochemical Properties

An optimized one-pot recipe has been developed to synthesize a surfactant molecule, referred to as OMID, consisting of an imidazoline head group and aliphatic tail, which is an exemplar corrosion inhibitor for carbon steel in acidic solutions. As evidenced by gas chromatography, ¹H and ¹³C nuclear magnetic resonance, and Fourier-transform infrared data, a high-purity product was achieved without the use of either a solvent or catalyst. Critical micelle concentration values and corrosion inhibition efficiencies ( η %) were determined in aqueous solutions of hydrochloric acid and sulfuric acid using surface tensiometry and linear polarization resistance measurements, respectively. Hydrolysis of the imidazoline head group as a function of pH (0–11) was explored with ultraviolet–visible absorption spectroscopy. In addition, N 1s and C 1s X-ray photoelectron spectroscopy data were acquired from both surface-adsorbed OMID and a multilayer of the imidazoline head group of OMID. These latter data are highly relevant to those attempting to understand OMID inhibition chemistry.     

新型着色材料——速溶色浆粉的测试与应用

介绍了通过初级颜料的润湿、研磨与分散、稳定处理技术,使助剂和树脂均匀地包裹在颜料表面,并通过特殊工艺制得水性和油性色浆粉,并赋予了很好的速溶性和分散性。     

Inhibition of Spore Germination of Phakopsora Pachyrhizi Using Crude Extracts of Amaranthus Spinosus

The effectiveness of methanolic and n-hexane crude extracts of Amaranthus spinosus to inhibit the spore germination of Phakopsora pachyrhizi, a causal agent of soybean rust disease was studied. Both methanolic and n-hexane crude extracts inhibited spore germination at concentrations of 0.1% to 5.0%. Methanolic extract of the roots at a concentration of 2.5% inhibited 55% of spore germination, and this result was similar when higher concentration at 5% of methanolic and n-hexane extracts of the flowers was used. The presence of alkaloids, flavonoids, tannins, saponins, and terpenoids in the extract may be responsible for the inhibition. The extract was potential to be utilized as a botanical fungicide.     

低剂量抑制剂Inhibex501存在下的甲烷水合物相平衡研究

含动力学抑制剂的天然气水合物相平衡研究对新型低剂量抑制剂的开发具有指导作用。在283.6 ~ 290.9 K和7.51 MPa ~ 15.97 MPa的温压范围内研究了抑制剂Inhibex501及其溶剂2-乙二醇单丁醚对甲烷水合物相平衡条件的影响。实验结果显示，0.5wt%和2.0wt%浓度的Inhibex501对甲烷水合物形成的热力学条件具有促进作用，能使甲烷水合物形成移向更高的温度或者更低的压力，而2-乙二醇单丁醚在浓度0.2wt% ~ 1.0wt%范围几乎不改变甲烷水合物形成的热力学条件，N-乙烯基己内酰胺与N-乙烯基吡咯烷酮的共聚物对水合物形成热力学条件的改变起主要作用。     

Corrosion behaviour of AA2024 aluminium alloy in different tempers in NaCl solution and with the CeCl3 corrosion inhibitor

The paper analyses the corrosion behaviour of naturally and artificially aged AA2024 alloy in NaCl solution and in the presence of an environment-friendly corrosion inhibitor, CeCl₃. On the basis of the values of polarisation resistance and corrosion current density, the corrosion resistance of the protective inhibitor film is established as well as the general corrosion resistance of this aluminium alloy. Resistance to pit formation is determined based on the difference in pitting and corrosion potentials while resistance to pit growth is determined based on the amount of charge consumed during pit growth. A scanning electron microscope is used to examine the morphology of the pits formed during the pitting corrosion testing, as well as to determine the cerium content on intermetallic particles and the matrix AA2024 alloy. The corrosion behaviour of AA2024 alloy is investigated after different test periods in NaCl solution and in the same solution with the CeCl₃ inhibitor. The corrosion resistance of both tempers of AA2024 alloy is more than one order of magnitude higher in the presence of CeCl₃. An explanation of the observed differences in the corrosion behaviour of the naturally and artificially aged AA2024 alloy is proposed. Different corrosion behaviour of the alloy after different test periods is also explained.     

溶聚丁苯橡胶连续聚合工艺

概述了溶聚丁苯橡胶连续聚合工艺的凝胶抑制技术．指出连续聚合丁艺的重点是确定合适的抑凝体系；N，N，N＇，N’-四甲基乙烯基二胺／1，2-丁二烯以及四氢呋喃／1，2-丁二烯是最常用的抑凝体系。综述了单釜连续聚合和多釜串联连续聚合工艺．对世界各大橡胶公司的连续聚合反应釜的结构进行了介绍。     

阳离子型高温酸化缓蚀剂的合成及其性能评价

针对Mannich碱型缓蚀剂存在的溶解性不好和缓蚀率不高等问题,以甲醛、环己酮和苯胺为原料,合成了一种Mannich碱型缓蚀剂CH-9,将其阳离子化后,再与丙炔醇复配,得到了阳离子型高温酸化缓蚀剂CH-10。由室内性能评价可知,CH-10在盐酸中有良好的溶解分散性;与酸液中其他添加剂如粘土稳定剂和铁离子稳定剂的配伍性良好,不会对酸化地层造成堵塞;在90℃和常压下,在20%HCl溶液中加入浓度为1%的CH-10,其对N80钢片的腐蚀速率为4.765g/(m2·h);在120℃时,浓度为2%的CH-10对N80钢片的腐蚀速率为14.30g/(m2·h),均达到了SY/T5405-1996标准中的一级标准。     

咪唑啉型缓蚀剂的合成及其缓蚀性能研究

以棕榈酸、二乙烯三胺为原料合成咪唑啉，并对其进行水溶性改性制备了咪唑啉型缓蚀剂YG-1，与助剂硫脲复配得到复配缓蚀体系YG-2。应用静态挂片失重法、电化学法评价了该复配缓蚀体系YG-2的缓蚀性能，研究了缓蚀机理，并用扫描电镜分析了腐蚀前后及加入复配缓蚀体系YG-2后A3钢的表面形貌。研究结果表明，在30℃下加入复配缓蚀体系YG-2能有效地抑制饱和CO2的高矿化度盐水对A3钢的腐蚀，其使用浓度为20mg／L时，缓蚀率达到98．5％，腐蚀速率仅为0．009mm／a，远好于我国石油天然气行业标准规定的指标。     

油田污水处理及酸化缓蚀剂的应用

介绍了油田污水处理及酸化中的几类缓蚀剂,重点介绍了咪唑啉型缓蚀剂、膦系缓蚀剂、曼尼希碱、炔醇等四类目前使用较多的缓蚀剂。结合缓蚀剂的分子结构阐述了其作用机理,论述了污水用缓蚀剂和酸化用缓蚀剂分子结构的区别及原因,并探讨了今后研究和发展的方向。