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Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review
Konrad Wojnarowski Paulina Cholewiska Duan Pali Magorzata Bednarska Magdalena Jarosz Iga Winiewska 《International journal of molecular sciences》2022,23(5)
Estrogen receptors (ERs) play a key role in many biochemical and physiological processes, that are involved in maintaining organism homeostasis. At the most basic level, they can be divided into nuclear estrogen receptors and membrane estrogen receptors that imply their effect in two ways: slower genomic, and faster non-genomic. In these ways, estrogens and xenoestrogens can negatively affect animal health and welfare. Most of the available literature focuses on human and mammalian physiology, and clearly, we can observe a need for further research focusing on complex mutual interactions between different estrogens and xenoestrogens in aquatic animals, primarily fishes. Understanding the mechanisms of action of estrogenic compounds on the ERs in fishes and their negative consequences, may improve efforts in environmental protection of these animals and their environment and benefit society in return. In this review, we have summarized the ER-mediated effects of xenoestrogens and estrogens on teleost fishes metabolism, their carcinogenic potential, immune, circulatory, and reproductive systems. 相似文献
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采用高效液相色谱法测定化妆品中3种雌激素(雌三醇、炔雌醇、戊酸雌二醇)。结果表明,在Welchrom-C18(4.6 mm×150 mm,5μm)色谱柱上,以甲醇和水作为流动相,检测波长281 nm,流速为1.0 m L/min,柱温30℃,可以较好的分离和测定化妆品中3种雌激素。该方法检测出的3种雌激素的相对标准偏差为0.26%~0.84%,回收率为92%~97%。 相似文献
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Zacharias Frontistis Christina Brebou Danae Venieri Dionissios Mantzavinos Alexandros Katsaounis 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2011,86(10):1233-1236
This work reports for the first time the removal of 17α‐ethynylestradiol (EE2), a synthetic estrogen hormone, from secondary treated effluents by electrochemical oxidation. Experiments were conducted in a single compartment reactor comprising a boron‐doped diamond (BDD) anode and a zirconium cathode. EE2, in the range 100–800 µg L?1, was spiked in the post‐chlorination effluent of a municipal treatment plant and oxidized at 0.9–2.6 mA cm?2 current density. Complete degradation of 100 µg L?1 EE2 was achieved in 7 min at 2.1 mA cm?2 and inherent conditions, while the addition of 0.1 mol L?1 NaCl achieved removal in just a few seconds. The process was then tested in the pre‐chlorination effluent at 2.1 mA cm?2 and inherent conditions; complete E. coli killing and EE2 removal occurred in just 1.5 and 3.5 min, respectively, while overall estrogenicity (assessed by the YES assay) and residual organic matter (in terms of chemical oxygen demand (COD)) decreased by 50% and 85% after 30 min, respectively. These results clearly show the potential of BBD electrochemical oxidation to serve as an efficient tertiary wastewater treatment. Copyright © 2011 Society of Chemical Industry 相似文献
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《分离科学与技术》2012,47(6):777-785
Abstract High loads on GPC columns usually lead to poor efficiency because of steep viscosity gradients. A great difference in density between solution and solvent can also cause excessive band broadening. However, under certain conditions good separations are achieved with loads of 150 mg/100 cc column volume and higher. Two mechanisms are proposed to explain this phenomenon. Secondary exclusion is caused by obstruction of pores to larger molecules by the more rapidly diffusing small molecules. It takes place predominantly with molecules of less than 2000 molecular weight in small pore gels. Incompatibility is caused by repulsive interaction between solute molecules and the polystyrene gel. It is observed with solutes which are chemically quite different from polystyrene, e.g., with polyvinyl acetate, and in a low to intermediate molecular weight range. 相似文献
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Don Woong Choi Jee Yeun Kim Seon Hee Choi Hee Su Jung Hyo Joo Kim So Yean Cho Chan Soon Kang Seung Yeup Chang 《Food chemistry》2006
Although it has been known that pomegranate (Punica granatum L.) contains several steroid hormones, concrete experimental proofs about that have not been published until now. In order to identify and evaluate the contents of steroid hormones including estrone in pomegranate, we analyzed pomegranate seed, fruit juice and commercial preparations. We developed a reproducible and sensitive method for separation and identification of steroid hormones in pomegranate samples using both high performance liquid chromatography (HPLC)–PDA and gas chromatography (GC)–MS. In case of HPLC, an isocratic elution method using 35% aqueous acetonitrile solution at 1.0 ml/min with photodiode-array (PDA) detection at 225 nm and 254 nm was found to optimally separate and identify the steroid hormones from the pomegranate samples with a run time of less than 30 min. The pomegranate samples were comparatively analyzed to the HPLC results by GC/FID or GC/MS detection on a HP-1 (30 m length, 0.32 mm I.D.) with helium as carrier gas under the oven temperature control as follows: start 220 °C for 5 min, raising 5 °C per min, final 280 °C for 10 min. The HPLC and GC methods were successfully applied to the identification of steroid hormones in pomegranate samples. Our results suggested that there were no steroid estrogens including estrone, estradiol and testosterone in pomegranate seed, fruit juice and preparations. Consequently, we assumed that the previously reported analysts of pomegranate were misunderstood their analytical results according to either the estrogen-like effects or similarity of peak retention time and Rf values in experiments. 相似文献
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Mickey Wilson Veera Konda Kathryn Heidt Thirumurugan Rathinasabapathy Anuradha Desai Slavko Komarnytsky 《International journal of molecular sciences》2021,22(3)
Ovarian insufficiency and ovariectomy are characterized by deregulated heat loss mechanisms. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ERβ receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. In this study, we examined the relationship between oral administration of ERr 731 and the underlying components of skin vasomotion responses in an ovariectomized (OVX) rat model. ERr 731 dose-dependently reduced tail skin temperature (Tskin) values by an average of 1 °C. The rapid onset of this effect was observed in 1 and 3 mg/kg/day ERr 731 groups as early as day 2 of administration, and remained in place for the duration of the treatment (2 weeks). Substituting ERr 731 after E2 withdrawal helped maintain body temperature similarly to E2 alone, suggesting the usefulness of ERr 731 for replacing existing hormonal therapy in humans. ERr 731 also acted as a highly selective agonist for ERβ in the hypothalamus of OVX rats, as well as in ERα/β cell-based reporter assays. These data validate the OVX/Tskin rat model as a suitable screening platform to evaluate botanical and pharmaceutical treatments of menopause, while providing further evidence for the efficacy of ERr 731 towards alleviating vasomotor menopausal symptoms and improving wellbeing during the menopausal transition. 相似文献
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简要介绍了人和牛初乳、常乳及其制品中天然雌性激素的种类、结构、含量、存在状态,并讨论了常规乳品加工对不同雌性激素的影响. 相似文献
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