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排序方式: 共有198条查询结果,搜索用时 15 毫秒
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Controlling micro‐ and nanofibrillar morphology of polymer blends in low‐speed melt spinning process. Part II: Influences of extrusion rate on morphological changes of a PLA/PVA blend through a capillary die 下载免费PDF全文
Nguyen Hoai An Tran Harald Brünig Maria Auf der Landwehr Roland Vogel Jürgen Pionteck Gert Heinrich 《应用聚合物科学杂志》2016,133(47)
The effects of the extrusion rate on the morphological changes of poly(lactic acid) (PLA)/poly(vinyl alcohol) (PVA) blend through a capillary die were investigated. In this study, the extrusion rate or mass flow rate is altered from 0.5 g min?1 to 2 g min?1 with an increment of 0.5 g min?1. The PLA/PVA blend with a composition of 30/70 (wt %) exhibits a particle matrix morphology with dispersed PLA droplets within the PVA matrix. It is found that, the spherical or ellipsoidal dispersed PLA droplets are elongated and coalesced into rod‐like or longer ellipsoidal droplets when they pass through the capillary die. When the extrusion rate increases, the coalescence between the large PLA droplets occurs more intense. However, the changes of the extrusion rate have no strong effect on the coalescence of small droplets having diameter less than about 150 nm. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 44257. 相似文献
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Inhibition of hIAPP Amyloid Aggregation and Pancreatic β‐Cell Toxicity by OH‐Terminated PAMAM Dendrimer 下载免费PDF全文
Esteban N. Gurzov Bo Wang Emily H. Pilkington Pengyu Chen Aleksandr Kakinen William J. Stanley Sara A. Litwak Eric G. Hanssen Thomas P. Davis Feng Ding Pu Chun Ke 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(12):1615-1626
Human islet amyloid polypeptide (hIAPP, or amylin) forms amyloid deposits in the islets of Langerhans, a phenomenon that is associated with type‐2 diabetes impacting millions of people worldwide. Accordingly, strategies against hIAPP aggregation are essential for the prevention and eventual treatment of the disease. Here, it is shown that generation‐3 OH‐terminated poly(amidoamine) dendrimer, a polymeric nanoparticle, can effectively halt the aggregation of hIAPP and shut down hIAPP toxicity in pancreatic MIN6 and NIT‐1 cells as well as in mouse islets. This finding is supported by high‐throughput dynamic light scattering experiment and thioflavin T assay, where the rapid evolution of hIAPP nucleation and elongation processes is halted by the addition of the dendrimer up to 8 h. Discrete molecular dynamics simulations further reveal that hIAPP residues bound strongly with the dendrimer near the c‐terminal portion of the peptide, where the amyloidogenic sequence (residues 22–29) locates. Furthermore, simulations of hIAPP dimerization reveal that binding with the dendrimer significantly reduces formation of interpeptide contacts and hydrogen bonds, thereby prohibiting peptide self‐association and amyloidosis. This study points to a promising nanomedicinal strategy for combating type‐2 diabetes and may have broader implications for targeting neurological disorders whose distinct hallmark is also amyloid fibrillation. 相似文献
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Donglin Bai Jiayi Wang Tianhe Li Ryan Chan Mena Atalla Robert C. Chen Mohammad T. Khazaneh Raphael J. An Peter B. Stathopulos 《International journal of molecular sciences》2021,22(15)
Twenty-one human genes encode connexins, a family of homologous proteins making gap junction (GJ) channels, which mediate direct intercellular communication to synchronize tissue/organ activities. Genetic variants in more than half of the connexin genes are associated with dozens of different Mendelian inherited diseases. With rapid advances in DNA sequencing technology, more variants are being identified not only in families and individuals with diseases but also in people in the general population without any apparent linkage to Mendelian inherited diseases. Nevertheless, it remains challenging to classify the pathogenicity of a newly identified connexin variant. Here, we analyzed the disease- and Genome Aggregation Database (gnomAD, as a proxy of the general population)-linked variants in the coding region of the four disease-linked α connexin genes. We found that the most abundant and position-sensitive missense variants showed distinct domain distribution preference between disease- and gnomAD-linked variants. Plotting missense variants on topological and structural models revealed that disease-linked missense variants are highly enriched on the structurally stable/resolved domains, especially the pore-lining domains, while the gnomAD-linked missense variants are highly enriched in the structurally unstable/unresolved domains, especially the carboxyl terminus. In addition, disease-linked variants tend to be on highly conserved residues and those positions show evolutionary co-variation, while the gnomAD-linked missense variants are likely on less conserved residue positions and on positions without co-variation. Collectively, the revealed distribution patterns of disease- and gnomAD-linked missense variants further our understanding of the GJ structure–biological function relationship, which is valuable for classifying the pathogenicity of newly identified connexin variants. 相似文献
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A study of ventricular fibrillation (VF) and ventricular tachycardia (VT) was undertaken using modified sample entropy analysis. Sample entropy (SampEn) is believed to provide the quantitative information about the complexity of experimental data that is corrupted by noise, short in data length. However, the similarity definition of vectors is based on a Heaviside function, of which the boundary is discontinuous and hard, which may cause the problems in the validity and accuracy of SampEn. To deal with the encountered problems, a modified sample entropy (mSampEn) based on fuzzy membership function was proposed. Its performances on characterizing VF and VT signals, as well as several simulated time series, demonstrate that mSampEn can more efficiently measure the complexity of time series. It is shown that, as a criteria for discriminating between VF and VT, mSampEn provides a significantly (p < 0.0001) higher (99%) accuracy rate than the standard one. 相似文献
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Lyocell纤维——减少原纤化的替代方法 总被引:5,自引:0,他引:5
除了用树脂整理来减少Lyocell纤维原纤化之外,还存在其他可能,本文对 可能性进行了研究。反应性染料由于结构和浓度因素而影响原纤维化性能,甚至连无色的反应性物质也能对此造成影响,这很容易由Lyocell纤维的湿态抗原纤维所证实。对抗皱与洗旧性也进行了评价。 相似文献
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Kyoung-Im Cho Sang-Ho Koo Tae-Joon Cha Jung-Ho Heo Hyun-Su Kim Gee-Bum Jo Jae-Woo Lee 《International journal of molecular sciences》2014,15(8):14803-14818
Increased atrial oxidative stress has an important role in inducing and maintaining atrial fibrillation (AF), and the activation of the small GTPase Rac1 contributes to the oxidative stress. We investigated the relationship of Rac1, atrial endothelial thromboprotective markers and AF inducibility and if simvastatin has a potential beneficial effect on a myocardial infarction (MI)-induced heart failure (HF) rat model. Rats were randomized into three groups (shams, MI group and simvastatin treatment group) and underwent echocardiography, AF induction studies and left atrial (LA) fibrosis analysis. Atrial Rac 1, sodium calcium exchanger (INCX), sarcoplasmic reticulum calcium ATPase (SERCA), endothelial nitric oxide synthase (eNOS) and induced nitric oxide synthase (iNOS) were measured. AF inducibility, AF duration and LA fibrosis were significantly higher in the MI group (p < 0.001 vs. sham), which were significantly reduced by simvastatin (p < 0.05 vs. MI). The reduced expressions of atrial eNOS, SERCA, thrombomodulin, tissue factor pathway inhibitor and tissue plasminogen activator in the MI group were significantly improved by simvastatin. Furthermore, the increased expression of atrial iNOS, INCX and Rac1 activity were significantly decreased by the simvastatin. Oxidative stress, endothelial dysfunction and thrombogenicity are associated with the promotion of AF in a rat model of ischemic HF. These were associated with increased Rac1 activity, and simvastatin treatment prevents these changes. 相似文献
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