丙烯酰胺代谢机理及其体内毒性防护的研究进展

丙烯酰胺是一种潜在的致癌物,自2002年被报道在热加工食品中高含量存在后,引起了国际社会的广泛关注.有研究发现,丙烯酰胺对人体的危害主要是由于其代谢产物环氧丙酰胺造成的.本文综述了近年来在环氧丙酰胺的分析方法、代谢机理、基因毒性等方面的研究进展；并结合利用天然产物抑制丙烯酰胺体内毒性的研究成果,对其危害的深层次防护提出...     

The influence of demographic,physical, behavioral,and dietary factors on hemoglobin adduct levels of acrylamide and glycidamide in the general U.S. population

Purpose: This study aims to better understand the individual characteristics and dietary factors that affect the relationship between estimated consumption of acrylamide and measured acrylamide hemoglobin adduct levels (HbAA) and glycidamide hemoglobin adduct levels (HbGA). Methods: Acrylamide levels in individual food items, estimated by the U.S. Food and Drug Administration, were linked to data collected in the 2003–2004 National Health and Nutrition Examination Survey. Multivariable linear regression was used to evaluate the relationship between estimated consumption of acrylamide and HbAA. Results: A significant association between acrylamide intake and HbAA was observed, after adjustment for gender, race/ethnicity, smoking status, age, and BMI (R² = 0.34). Across quartiles of acrylamide consumption, HbAA and HbGA levels increased monotonically. Among nonsmokers, an evaluation of three heavily consumed, high AA concentration foods showed a positive trend between the consumed amount of fried potatoes and HbAA in children, adolescents, and adults. A significant positive trend between the consumed amount of potato chips or coffee was indicated in adolescents, adults, and seniors. Conclusions: Consumption of some individual foods affects HbAA concentrations more strongly and in an age-dependent manner. Our results suggest that effective dietary guidelines for controlling acrylamide intake should be subpopulation specific.