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Ji Hyun Lee Han Na Park Bogonda Ganganna Ji Hye Jeong Sung-Kwan Park 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2016,33(6):945-952
A new tadalafil analogue was found, along with nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The analogue was separated using a semi-preparative HPLC system and its structure was determined by a combination of mass spectrometry and NMR spectroscopy. The compound was identified as a tadalafil analogue in which the N-methyl group of tadalafil was replaced with a tadalafil precursor moiety. Nuclear Overhauser effect spectroscopy experiments suggested a cis-relationship between the substituents on a piperidine ring in the tadalafil moiety. 相似文献
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