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Friederike Freiin von Hvel Ekaterini Kefalakes Claudia Grothe 《International journal of molecular sciences》2021,22(1)
Fibroblast growth factor 2 (FGF-2), ubiquitously expressed in humans and mice, is functionally involved in cell growth, migration and maturation in vitro and in vivo. Based on the same mRNA, an 18-kilo Dalton (kDa) FGF-2 isoform named FGF-2 low molecular weight (FGF-2LMW) isoform is translated in humans and rodents. Additionally, two larger isoforms weighing 21 and 22 kDa also exist, summarized as the FGF-2 high molecular weight (FGF-2HMW) isoform. Meanwhile, the human FGF-2HMW comprises a 22, 23, 24 and 34 kDa protein. Independent studies verified a specific intracellular localization, mode of action and tissue-specific spatiotemporal expression of the FGF-2 isoforms, increasing the complexity of their physiological and pathophysiological roles. In order to analyze their spectrum of effects, FGF-2LMW knock out (ko) and FGF-2HMWko mice have been generated, as well as mice specifically overexpressing either FGF-2LMW or FGF-2HMW. So far, the development and functionality of the cardiovascular system, bone formation and regeneration as well as their impact on the central nervous system including disease models of neurodegeneration, have been examined. This review provides a summary of the studies characterizing the in vivo effects modulated by the FGF-2 isoforms and, thus, offers a comprehensive overview of its actions in the aforementioned organ systems. 相似文献
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Lalumiére Martin L.; Quinsey Vernon L.; Beninger Richard D.; Barsetti Ian; Earls Christopher M. 《Canadian Metallurgical Quarterly》1993,34(4):461
Discusses controversies surrounding the work of B. F. Skinner's influence on various theories of human and animal behavior. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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A decay of fresh-cut celery (Apium graveolens) segments stored at < 5°C in sealed film bags began with a water soaking of the cut surfaces. Slimy moisture accumulated inside the bags. The segments water soaked completely, softened, discolored and sometimes disintegrated. Total aerobic bacterial populations isolated from decayed segments ranged from log10 7.0–7.7 CFU/g tissue weight. The predominant bacteria, identified by fatty acid analysis as Pseudomonas fluorescens and P. marginalis, caused water soaking, soft rot, and discoloration in freshly inoculated celery tissues stored at 5 or 25°C. Leuconostoc mesenteroides was also isolated and may have been responsible for slime production. 相似文献
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从采油菌剂及原油中共分离出11株细菌,并对其发酵特性和生理生化特性进行研究。结果表明,分离菌株可以利用石蜡产表面活性物质,但不产气;菌株发酵液的pH值没有明显的变化,对原油有不同程度的乳化作用;Y-1和Y-5为芽孢杆菌属(Bacillus),Y-2和Y-6为节杆菌属(Arthrobacter),Y-3为棒杆菌属(Corynebacterium),Y-4、J-1、J-2、J-4、J-5和J-6为不动杆菌属(Acinetobacter)。大多数分离菌株为兼性厌氧菌,具有运动性,不产生硫化氢,能够利用蔗糖、葡萄糖等廉价碳源产生有机酸和气体,这些特性有利于菌株应用于微生物采油。 相似文献
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为提升飞行员弹射救生系统试验中人体生理损伤指标的测试能力和测试可靠性,结合航空仿真试验假人的结构,提出了分布式测试系统的设计、配置方案,设计了系统触发及同步控制电路,试验结果表明,系统能够在不影响假人生物仿真性能的前提下,可靠实现弹射试验人体生理损伤指标的测试. 相似文献
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Strombus gigas and Strombus pugilis are threatened species and aquaculture represents a good alternative solution to the fishing. In this study, we highlighted the intracellular digestion process in the digestive gland of two Strombidae species, S. gigas and Strombuspugilis, by the cytochemical characterization of two lysosomal enzymes: acid phosphatase and arylsulfatase. In order to check the efficiency of artificial food digestion, we conducted the characterization on freshly collected, starved and artificially fed individuals of S. pugilis. TEM observations of digestive gland sections from freshly collected individuals of both species revealed the presence of acid phosphatase and arylsulfatase activity mostly located in the apical third of digestive cells. Both enzymes were also detected in artificially fed individuals. In response to the starvation, acid phosphatase is not produced anymore by digestive cells, while arylsulfatase is still present. To our knowledge, this is the first cytochemical validation of intracellular digestion of artificial food in Strombidae. This study highlights the intracellular digestion of artificial food developed for Strombidae aquaculture. Moreover, we have shown that the lysosomal activity could be used as a feed index. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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