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排序方式: 共有3301条查询结果,搜索用时 93 毫秒
1.
Corey Andrews Yiting Xu Michael Kirberger Jenny J. Yang 《International journal of molecular sciences》2021,22(1)
Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM’s ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that make them good binding partners for CaM. Additionally, we discuss the historical and current methods for predicting CaM binding, and the similarities and differences between these methods and their relative success at prediction. As new CaM-binding proteins are identified and classified, we will gain a broader understanding of the biological processes regulated through changes in Ca2+ concentration through interactions with CaM. 相似文献
2.
Ensemble pruning deals with the selection of base learners prior to combination in order to improve prediction accuracy and efficiency. In the ensemble literature, it has been pointed out that in order for an ensemble classifier to achieve higher prediction accuracy, it is critical for the ensemble classifier to consist of accurate classifiers which at the same time diverse as much as possible. In this paper, a novel ensemble pruning method, called PL-bagging, is proposed. In order to attain the balance between diversity and accuracy of base learners, PL-bagging employs positive Lasso to assign weights to base learners in the combination step. Simulation studies and theoretical investigation showed that PL-bagging filters out redundant base learners while it assigns higher weights to more accurate base learners. Such improved weighting scheme of PL-bagging further results in higher classification accuracy and the improvement becomes even more significant as the ensemble size increases. The performance of PL-bagging was compared with state-of-the-art ensemble pruning methods for aggregation of bootstrapped base learners using 22 real and 4 synthetic datasets. The results indicate that PL-bagging significantly outperforms state-of-the-art ensemble pruning methods such as Boosting-based pruning and Trimmed bagging. 相似文献
3.
就经典分水岭图像分割算法中存在的过分割问题,提出一种结合位图切割和区域合并的彩色图像分割算法。对原始彩色图像通过空域梯度算子求其梯度图像,并利用位图切割重建梯度图像;对新梯度图像进行分水岭预分割;对预分割图像基于异质性最小原则进行区域合并,并获得最终分割结果。相比于现有的同类方法,该算法引入位图切割,抑制噪声对分割结果的影响,在边缘模糊处分割准确,得到符合人类视觉的较小分割区域数目,同时在运行效率上提高。 相似文献
4.
多输入单输出逆高斯分布流域汇流模型 总被引:1,自引:0,他引:1
本文将逆高斯分布应用于由水库和区间组成的复杂的流域汇流系统,并建立了多输入单输出逆高斯单位线模型。讨论了模型参数的估计方法,并对沾益流域的雨洪资料进行了实例分析。 相似文献
5.
Emina Krcmar Ilan Vertinsky G. Cornelis van Kooten 《International Transactions in Operational Research》2003,10(5):483-498
To satisfy public demands for environmental values, forest companies are facing the prospect of a reduction in wood supply and increases in costs. Some Canadian provincial governments have proposed intensifying silviculture in special zones dedicated to timber production as the means for pushing out the forest possibility frontiers. In this paper, we compare the traditional two‐zone land allocation framework which includes ecological reserves and integrated forest management zones with the triad — a three‐zone scheme which adds a zone dedicated to intensive timber production. We compare the solutions of the mixed‐integer linear programs formulated under both land‐allocation frameworks. We explore through sensitivity analysis the conditions under which the triad regime can offset the impact on timber production from increased environmental demands. We show that under the realistic conditions characteristic to Coastal British Columbia, higher environmental demands may be satisfied under the triad regime without increasing the financial burdens on the industry or reducing its wood supply. This occurs, however, only if regulatory constraints in timber production zone are flexible. 相似文献
6.
Bryce J. Stokes 《Biomass & bioenergy》1992,2(1-6):131-147
Eight countries collaborated and shared technical information on the harvesting of small trees and forest residues in a three year program. Proceedings and reports from workshops and reviews are summarized in a review of activities and harvesting systems of the participating countries. Four databases were developed for harvesting and transportation of these materials. 相似文献
7.
8.
Exchanges of total N and C between a river and its floodplain forest have been enhanced by sedimentation processes during flood pulses at a 5‐ha bottomland hardwood forest located at the Olentangy River Wetland Research Park in central Ohio. In the spring of 2000, the forest was hydrologically restored by notching an artificial levee that had separated the Olentangy River and its floodplain forest for 100 years. One‐hundred flat sediment traps (30 cm × 30 cm) were used to collect sediment samples during spring/summer flooding events from 2003 to 2005. Results showed that sediment deposition is determined by the landscape variability during flooding events, Net sediment deposit in the wettest area averaged 134 ± 12 g‐dry wt m?2 in 2003, 127 ± 17 g‐dry wt m?2 in 2004 and 149 ± 23 g‐dry wt m?2 in 2005. Total N and C sedimentation ranged from 0.49 to 0.92 g‐N m?2 and 5.2 to 19.9 g‐C m?2. Fe dominates the sediment chemistry and results show the elemental abundance in the order of Al > Fe > Ca > K > Mg > S > P > Na > Mn > Zn > B > Cu > Mo. A hydrologic pulsing index (HPI) could be used as an indicator for mass changes of energies with hydrologic pulsing events. Restoration of seasonally flooded bottomland forests could stimulate potentially large nutrient and Fe releases, which would eventually lead to an enhanced forest productivity and biodiversity. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
9.
An Interval Fuzzy Multiobjective Watershed Management Model for the Lake Qionghai Watershed, China 总被引:4,自引:0,他引:4
Lijing Wang Wei Meng Huaicheng Guo Zhenxing Zhang Yong Liu Yingying Fan 《Water Resources Management》2006,20(5):701-721
Integrated watershed management is required to ensure the reasonable use of resources and reconcile interactions among natural and human systems. In the present study, an interval fuzzy multiobjective programming (IFMOP) method was used to solve an integrated watershed management problem. Based on system analysis, an IFMOP model suitable for a lake watershed system {IFMOPLWS} was developed and applied to the Lake Qionghai watershed in China. Scenario analysis and an interactive approach were used in the solution process. In this manner, various system components were incorporated into one framework for holistic consideration and optimization. Integrality and uncertainty, as well as the multiobjective and dynamic characteristics of the watershed system, were well addressed. Using two scenarios, two planning schemes were generated. Agriculture, tourism, macroeconomics, cropland use, water supply, forest coverage, soil erosion, and water pollution were fully interpreted and compared to identify a preferable planning alternative for local agencies. This study showed that the IFMOPLWS is a powerful tool for integrated watershed management planning and can provide a solid base for sustainable watershed management. 相似文献
10.