Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration

Lipoxins (LXs) are autacoids, specialized proresolving lipid mediators (SPMs) acting locally in a paracrine or autocrine fashion. They belong to a complex superfamily of dietary small polyunsaturated fatty acid (PUFA)–metabolites, which direct potent cellular responses to resolve inflammation and restore tissue homeostasis. Together, these SPM activities have been intensely studied in systemic inflammation and acute injury or infection, but less is known about LX signaling and activities in the central nervous system. LXs are derived from arachidonic acid, an omega‐6 PUFA. In addition to well‐established roles in systemic inflammation resolution, they have increasingly become implicated in regulating neuroinflammatory and neurodegenerative processes. In particular, chronic inflammation plays a central role in Alzheimer's disease (AD) etiology, and dysregulated LX production and activities have been reported in a variety of AD rodent models and clinical tissue samples, yet with complex and sometimes conflicting results. In addition, reduced LX production following retinal injury has been reported recently by the authors, and an intriguing direct neuronal activity promoting survival and homeostasis in retinal and cortical neurons is demonstrated. Here, the authors review and clarify this growing literature and suggest new research directions to further elaborate the role of lipoxins in neurodegeneration.     

挤扩支盘桩在湿陷性黄土地基中的应用

湿陷性黄土具有遇水发生湿陷、承载力大幅度降低的性质,这种性质直接影响到基础的承载力。为了研究支盘桩在湿陷性黄土地基中的承载性状,对湿陷性黄土中的3根支盘桩进行预浸水静载荷试验,结果表明,支盘桩荷载—沉降曲线为缓变型,具有较好的承载性能,荷载传递规律与在非湿陷性黄土地基中具有相似的性质,桩身各段承载力的发挥具有明显的顺序性,其结果为挤扩支盘桩在湿陷性黄土地基中的应用提供了依据。     

非饱和土的抗剪强度理论研究

从孔隙水的存在状态出发 ,围绕Bishop抗剪强度公式中存在的几个疑点展开讨论 .认为非饱和土中支配强度和变形的应力之所以不同 ,是因为非饱和土中存在一种性质与有效应力不同的应力———内部应力 ,它不传递 ,仅影响土的塑性变形 .同时还对Bishop ,Fredlund和卢肇钧提出的抗剪强度公式中的参数测试方法进行分析 ,指出 :各种抗剪强度理论在概念上都是相同的 ,其区别仅在于确定由吸力产生的那部分有效应力时采用的参数和测试方法不同     

饱和—非饱和土体非稳定渗流数值分析

本文对一般的非饱和渗流有限元计算方法加以改进，有效地消除了非饱和渗流数值计算中存在的数值弥散现象。同时还提出了一种简便有效的逸出面处理新方法，并给出了非饱和非稳定渗流计算的实例。     

Ultrasound‐activated Knoevenagel condensation of malononitrile with carbonylic compounds catalysed by alkaline‐doped saponites

α,β‐Unsaturated nitriles have been synthesized by Knoevenagel condensation of a carbonylic compound with malononitrile, assisted by sonochemical irradiation. Two alkaline‐promoted clays (Li⁺‐ and Cs⁺‐exchanged saponites) have been employed as catalysts. The influence of the carbonylic compound (benzaldehyde or cyclohexanone) and the use of a solvent on the catalytic activity have been studied. Remarkable increase in the conversion values has been found when the reaction is activated by ultrasound, as compared with the thermal activation. In this green, solvent‐free procedure, α,β‐unsaturated nitriles have been produced in very high yields (97%) when the Cs⁺‐saponite is used as catalyst. Copyright © 2004 Society of Chemical Industry     

Significance of fluid regime in biological filtration

A dispersed flow model previously developed to study substrate utilization in unsaturated media was experimentally verified and its practical application was considered. For this purpose, measurements were made using tap water and a synthetic feed solution. The importance of the change in fluid regime as regards to the simultaneous transport and reaction within biological filters were demonstrated. The effect of drop formation and the breakage of liquid jets inside the filters on substrate utilization was also shown.     

鄂尔多斯西缘前陆盆地巨厚黄土地区地震采集技术

鄂尔多斯西缘前陆盆地表层地质地貌极其复杂，有巨厚黄土区、黄土-沙漠区及山前砾石-黄土区，独特的黄土地貌使得地震采集面临着诸多技术难题。根据以往巨厚黄土地区地震采集经验，采用多种方法系统地开展黄土表层结构精细调查，深入研究黄土地球物理特征及激发因素与表层黄土结构之间的关系，优选激发井位和井深，确保了激发效果；采用小道距、三线小线距、高密度空间采样技术，获得了高信噪比、高分辨率地震资料。研究表明，巨厚黄土地区地震采集时应优选激发井位和岩性，合理选择激发井深；坚持多深井组合激发、单井药量不宜过大总药量要大两项基本原则；采用高密度采样技术，提高采集资料的覆盖次数和信噪比。图10表1参15     

端基封闭法合成双环戊二烯改性不饱和聚酯

研究端基封闭法合成双环戊二烯（ＤＣＰＤ）改性不饱和聚能工艺条件对产品性能的影响。研究结果表明，合成反应的最佳工艺条件为总酸酐：丙二醇：ＤＣＰＤ＝１：１．１：０．１─０．１６；封端反应温度１３０─１４０℃催化剂量为总重量的０．０２％─０．０３％；聚酯酸值５０ｍｇｋＯＨ·ｇ￣（－１）时滴加ＤＣＰＤ，滴加时间控制在１─２小时；加成反应时间为２小时左右。     

氯氧镁水泥对不饱和树脂的阻燃性能与阻燃机理研究

采用极限氧指数法、热重分析和烟密度测试法研究了氯氧镁水泥在不饱和树脂（UP）中的阻燃作用和阻燃机理。研究表明经偶联剂处理后的氯氧镁水泥对UP具有良好的阻燃抑烟效果，并通过增加UP在高温下的热稳定性和降低热失重速率等机理发挥阻燃作用：氯氧镁水泥含量在40％内对UP的力学性能影响较小，是一种新型的无机添加型阻燃剂。     

云台山隧道进口黄土段施工技术

从防排水、边仰坡支护、洞口加固、洞内超前支护、钢拱架锚喷联合支护等方面详细介绍了云台山隧道进口黄土段的施工技术,总结了该隧道的施工效果,强调了黄土隧道施工中防排水超前支护预注浆、施工监控的作用,积累了隧道施工经验.