A Bio-Conjugated Fullerene as a Subcellular-Targeted and Multifaceted Phototheranostic Agent

Fullerenes are candidates for theranostic applications because of their high photodynamic activity and intrinsic multimodal imaging contrast. However, fullerenes suffer from low solubility in aqueous media, poor biocompatibility, cell toxicity, and a tendency to aggregate. C₇₀@lysozyme is introduced herein as a novel bioconjugate that is harmless to a cellular environment, yet is also photoactive and has excellent optical and optoacoustic contrast for tracking cellular uptake and intracellular localization. The formation, water-solubility, photoactivity, and unperturbed structure of C₇₀@lysozyme are confirmed using UV-visible and 2D ¹H, ¹⁵N NMR spectroscopy. The excellent imaging contrast of C₇₀@lysozyme in optoacoustic and third harmonic generation microscopy is exploited to monitor its uptake in HeLa cells and lysosomal trafficking. Last, the photoactivity of C₇₀@lysozyme and its ability to initiate cell death by means of singlet oxygen (¹O₂) production upon exposure to low levels of white light irradiation is demonstrated. This study introduces C₇₀@lysozyme and other fullerene-protein conjugates as potential candidates for theranostic applications.     

基于词性特征的明喻识别及要素抽取方法

比喻是一种利用事物之间的相似点建立关系的修辞方式。明喻是比喻中最常见的形式,具有明显的喻词,例如"像",用于关联本体和喻体。近年来高考语文散文类鉴赏题中多有考查明喻句的试题,为了解答此类鉴赏题,需要识别比喻句中的本体和喻体要素。该文提出了基于词性特征的明喻识别及要素抽取方法。首先将句子中词向量化表示与词性特征向量化表示进行融合,将融合后的向量输入到BiLSTM中进行训练,然后利用CRF解码出全局最优标注序列;最后得到明喻识别和要素抽取的结果。公开数据集上的实验结果表明,该方法优于已有的单任务方法;同时也将该文方法应用于北京高考语文鉴赏题中比喻句的识别与要素抽取,验证了方法的可行性。     

An experiment for showing some kind of artificial understanding

In this paper we design an experiment which can be depicted as a simple scenario, a very limited 'world'. In this world, there are an actor that can pursue a project and an observer that is keeping its eyes on the actor. We try to show in the experiment that the observer can to some degree understand the actor based on its knowledge and some metaphors, i.e. understand what the actor is doing and why. As the conclusion of this experiment, we try to show some features of 'understanding'. These are (1) that 'understanding' has to be based on some preliminary knowledge; (2) that 'understanding' is a process of incremental learning; (3) that, as for symbolic systems, some metaphors are necessary for mapping real entities into concepts in mind.     

Review of Forms of feeling: The heart of psychotherapy.

Reviews the book, Forms of feeling: The heart of psychotherapy by Robert F. Hobson. Robert Hobson calls this book his autobiography as a therapist. As such it provides interesting glimpses into some of his more meaningful sessions with clients, illuminating his approach to therapy and enabling the reader to see a master therapist at work. Hobson also presents a new method of therapy, which he calls the conversational model. On this level, his book is considerably less satisfying. Hobson succinctly outlines the general principles of the conversational model and basic skills required of the therapist, but in so doing offers essentially little new information, however valid the points may be. According to Hobson, the conversational model is designed for clients whose problems arise from disturbances in their significant relationships, and those problems are best solved not by talking about them but by being in a relationship such as therapy that provides "a special kind of friendship." Hobson puts great stress on the use of metaphorical language in therapy and learning how to use the language of art as well as of science. He relies heavily on literary quotations, prefacing each section with one or two, and liberally interspersing many more within the pages of text. The net result is not so much illuminating as it is wearisome, and the general tone is slightly pretentious and, when Hobson addresses his "dear Reader" directly, somewhat condescending. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Multisensory exploration and object individuation in infancy.

Recent research indicates that by 4.5 months, infants use shape and size information as the basis for individuating objects but that it is not until 11.5 months that they use color information for this purpose. The present experiments investigated the extent to which infants' sensitivity to color information could be increased through select experiences. Five experiments were conducted with 10.5- and 9.5-month-olds. The results revealed that multimodal (visual and tactile), but not unimodal (visual only), exploration of the objects prior to the individuation task increased 10.5-month-olds' sensitivity to color differences. These results suggest that multisensory experience with objects facilitates infants' use of color information when individuating objects. In contrast, 9.5-month-olds did not benefit from the multisensory procedure; possible explanations for this finding are explored. Together, these results reveal how an everyday experience--combined visual and tactile exploration of objects--can promote infants' use of color information as the basis for individuating objects. More broadly, these results shed light on the nature of infants' object representations and the cognitive mechanisms that support infants' changing sensitivity to color differences. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Challenges and opportunities of multimodal data in human learning: The computer science students' perspective

Multimodal data have the potential to explore emerging learning practices that extend human cognitive capacities. A critical issue stretching in many multimodal learning analytics (MLA) systems and studies is the current focus aimed at supporting researchers to model learner behaviours, rather than directly supporting learners. Moreover, many MLA systems are designed and deployed without learners' involvement. We argue that in order to create MLA interfaces that directly support learning, we need to gain an expanded understanding of how multimodal data can support learners' authentic needs. We present a qualitative study in which 40 computer science students were tracked in an authentic learning activity using wearable and static sensors. Our findings outline learners' curated representations about multimodal data and the non-technical challenges in using these data in their learning practice. The paper discusses 10 dimensions that can serve as guidelines for researchers and designers to create effective and ethically aware student-facing MLA innovations.     

基于CCA的人耳和侧面人脸特征融合的身份识别*

鉴于人耳和人脸特殊的生理位置关系,从非打扰识别的角度出发,提出仅采集侧面人脸图像,利用典型相关分析的思想提取人耳和侧面人脸的关联特征,进行人耳和侧面人脸在特征层的融合.实验结果表明,此方法与单一的人耳或侧面人脸特征识别比较,识别率得到提高.     

Multimodal Pre-training Method for Vision-language Understanding and Generation

Most existing vision-language pre-training methods focus on understanding tasks and use BERT-like loss functions (masked language modeling and image-text matching) during pre-training. Despite their good performance in the understanding of downstream tasks, such as visual question answering, image-text retrieval, and visual entailment, these methods cannot generate information. To tackle this problem, this study proposes Unified multimodal pre-training for Vision-Language understanding and generation (UniVL). The proposed UniVL is capable of handling both understanding tasks and generation tasks. It expands existing pre-training paradigms and uses random masks and causal masks simultaneously, where causal masks are triangular masks that mask future tokens, and such pre-trained models can have autoregressive generation abilities. Moreover, several vision-language understanding tasks are turned into text generation tasks according to specifications, and the prompt-based method is employed for fine-tuning of different downstream tasks. The experiments show that there is a trade-off between understanding tasks and generation tasks when the same model is used, and a feasible way to improve both tasks is to use more data. The proposed UniVL framework attains comparable performance to recent vision-language pre-training methods in both understanding tasks and generation tasks. Moreover, the prompt-based generation method is more effective and even outperforms discriminative methods in few-shot scenarios.     

从社会符号学视角解读上海世博会吉祥物

当今社会已经步入了一个数字化和信息化的时代,随着人们的交流方式逐渐由文字向图像化转变,话语分析的研究范围也随之延伸到语言文字之外的图片、声音、颜色等社会符号。文章运用社会符号学框架下的视觉语法理论分析了2010年上海世博会吉祥物-海宝这个多模态语篇,说明除语言文字以外的其他社会符号也是意义的源泉。