Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain

Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Defects of adult hippocampal neurogenesis have been linked to cognitive decline and dysfunction during natural aging and in neurodegenerative diseases, as well as psychological stress-induced mood disorders. Understanding the mechanisms and pathways that regulate adult neurogenesis is crucial to improving preventative measures and therapies for these conditions. Accumulating evidence shows that mitochondria directly regulate various steps and phases of adult neurogenesis. This review summarizes recent findings on how mitochondrial metabolism, dynamics, and reactive oxygen species control several aspects of adult neural stem cell function and their differentiation to newborn neurons. It also discusses the importance of autophagy for adult neurogenesis, and how mitochondrial and autophagic dysfunction may contribute to cognitive defects and stress-induced mood disorders by compromising adult neurogenesis. Finally, I suggest possible ways to target mitochondrial function as a strategy for stem cell-based interventions and treatments for cognitive and mood disorders.     

Psychrophilic hydrogen production from petrochemical wastewater via anaerobic sequencing batch reactor: techno-economic assessment and kinetic modelling

Independent hydrogen production from petrochemical wastewater containing mono-ethylene glycol (MEG) via anaerobic sequencing batch reactor (ASBR) was extensively assessed under psychrophilic conditions (15–25 °C). A lab-scale ASBR was operated at pH of 5.50, and different organic loading rates (OLR) of 1.00, 1.67, 2.67, and 4.00 gCOD/L/d. The hydrogen yield (HY) progressed from 134.32 ± 10.79 to 189.09 ± 22.35 mL/gMEG_initial at increasing OLR from 1.00 to 4.00 gCOD/L/d. The maximum hydrogen content of 47.44 ± 3.60% was achieved at OLR of 4.0 gCOD/L/d, while methane content remained low (17.76 ± 1.27% at OLR of 1.0 gCOD/L/d). Kinetic studies using four different mathematical models were conducted to describe the ASBR performance. Furthermore, two batch-mode experiments were performed to optimize the nitrogen supplementation as a nutrient (C/N ratio), and assess the impact of salinity (as gNaCl/L) on hydrogen production. HY substantially dropped from 62.77 ± 4.09 to 6.02 ± 0.39 mL/gMEG_initial when C/N ratio was increased from 28.5 to 114.0. Besides, the results revealed that salinity up to 10.0 gNaCl/L has a relatively low inhibitory impact on hydrogen production. Eventually, the cost/benefit analysis showed that environmental and energy recovery revenues from ASBR were optimized at OLR of 4.0 gCOD/L/d (payback period of 7.13 yrs).     

基于学生群体心理测试系统的设计

心理测试的根本目的是为了让人们在测试过程中，产生某些特定行为，即个体对测试题目的反应，并根据这些行为反应来推论其相应的心理特性。在一定程度上帮助我们了解人类的心理活动，并从中得到帮助。因此，本文对基于学生群体心理测试系统的设计进行深入研究。     

论激励教育

分析了高职学生的心理、惩罚教育的弊端,并从理论、心理、现实论述的基础上提出应大力提倡激励教育.     

随机库存分配问题的一种求解方法

讨论了在VMI管理思想下对具有随机需求特性的多客户库存分配问题 ,重点论述了有效近似算法的设计过程 ,最后基于一组模拟数据给出了一个算例。     

一种智能型的PCB产业需求预测方法

目前需求预测在整个印制电路板产业的生产活动控制中正扮演着越来越重要的角色。分析了影响印制电路板需求的因素和现有的预测方法,提出了一种适用于PCB产业需求预测的有效方法——遗传/BP—神经网络。实验表明该方法能够进一步改善印制电路板预测的准确度和减少生产成本的消耗。     

Does life satisfaction moderate the effects of stressful life events on psychopathological behavior during adolescence?

Psychologists within a positive psychology framework have proposed the existence of a set of psychological strengths that buffer against the development of psychopathology. To date, most research efforts in positive psychology have focused on adults. This longitudinal study tested the prediction that adolescents' judgments of life satisfaction moderate the influence of stressful life events on the subsequent development of psychopathological behavior. Using a sample of 816 middle and high school students, the study demonstrated support for the moderational model for externalizing behavior outcomes, but not internalizing behavior problems. Specifically, adolescents with positive life satisfaction (vs. those who were dissatisfied with their lives) were less likely to develop later externalizing behaviors in the face of stressful life events. The study also revealed that adolescent life satisfaction reports show moderate stability across a one-year time frame and independently predict subsequent externalizing behavior even while controlling for prior levels of externalizing behavior... (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Occupational Factors and 5-Year Weight Change Among Men in a Danish National Cohort.

This study explored whether factors related to the work environment could predict changes in body mass index (BMI) and whether the effect of psychosocial factors was dependent on baseline BMI. The sample consisted of 1,980 male employees from the Danish National Work Environment Cohort Study. Changes in BMI between 1995 and 2000 were analyzed, by multiple regression, as a function of background variables and a series of occupational variables obtained in 1995. Age, baseline BMI, job insecurity, and psychological demands predicted changes in BMI. Job insecurity and high or low psychological demands increased the likelihood of weight gain among obese employees, whereas they increased the likelihood of weight loss among employees with a low BMI. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The Application of the Theory of the Price Elasticity of Demand to the EMS Management

1　Introduction　ExpressMailService (EMS )wasopenedupbyChinaPostintheearly 80stomeettheneedsofeco nomicdevelopment.It sthemostcompetitiveoneofthepostservices.There recivilaviation ,Chinarail wayandotherprivateexpressdeliverycompaniesdomesticallyandUPS ,TNT ,DHLandTEDEXcompetingwithEMSintheinternationalmarket.OneofthemostpowerfulcompeteweaponofthesecompaniesisthelowerpricethanEMS[1 ] .BecauseofthefiercecompetitionEMSdeclinedfromthemo nopolistindomesticandinternationalmarketoftheear…     

Study on the Complexity of the Bullwhip Effect

Recent years have witnessed a rapid growth of interest in the study of the dynamic behavior of replenishment rules of bullwhip effect. We prove that bullwhip effect and butterfly effect share a same the self-oscillation amplifying mechanism that is the ordering decisions the supplier self-oscillation amplify the perturbations brought by the errors in the processing of retailers' demand information. This results as an explicit self-similar structure of the sensitivity of the system to the initial values duty to the nonlinear mechanism. In this paper, the causes process of the bullwhip effect is described as the internal nonlinear mechanism and study on the complexity of bullwhip effect for order-up-to policy under demand signal processing. The methodology is based on fractal and chaotic theory and allows important insights to be gained about the complexity behavior of bullwhip effect.