Zika Virus Growth in Human Kidney Cells Is Restricted by an Elevated Glucose Level

Mosquito-borne Zika virus (ZIKV) became a real threat to human health due to the lack of vaccine and effective antiviral treatment. The virus has recently been responsible for a global outbreak leading to millions of infected cases. ZIKV complications were highlighted in adults with Guillain–Barré syndrome and in newborns with increasing numbers of congenital disorders ranging from mild developmental delays to fatal conditions. The ability of ZIKV to establish a long-term infection in diverse organs including the kidneys has been recently documented but the consequences of such a viral infection are still debated. Our study aimed to determine whether the efficiency of ZIKV growth in kidney cells relates to glucose concentration. Human kidney HK-2 cells were infected with different ZIKV strains in presence of normal and high glucose concentrations. Virological assays showed a decrease in viral replication without modifying entry steps (viral binding, internalization, fusion) under high glucose conditions. This decrease replication was associated with a lower virus progeny and increased cell viability when compared to ZIKV-infected HK-2 cells in normal glucose concentration. In conclusion, we showed for the first time that an elevated glucose level influences ZIKV replication level with an effect on kidney cell survival.     

An object replication algorithm for real-time distributed databases

A real-time distributed database system (RTDDBS) must maintain the consistency constraints of objects and must also guarantee the time constraints imposed by each request arriving at the system. Such a time constraint of a request is usually defined as a deadline period, which means that the request must be serviced on or before its time constraint. Servicing these requests may incur I/O costs, control-message transferring costs or data-message transferring costs. As a result, in our work, we first present a mathematical model that considers all these costs. Using this cost model, our objective is to service all the requests on or before their respective deadline periods and minimize the total servicing cost. To this end, from theoretical standpoint, we design a dynamic object replication algorithm, referred to as Real-time distributed dynamic Window Mechanism (RDDWM), that adapts to the random patterns of read-write requests. Using competitive analysis, from practical perspective, we study the performance of RDDWM algorithm under two different extreme conditions, i.e., when the deadline period of each request is sufficiently long and when the deadline period of each request is very short. Several illustrative examples are provided for the ease of understanding. Recommended by: Ashfaq Khokhar     

基于LotusNotes的文档ID应用剖析

介绍了文档数据库Lotus Domino／Notes的特点．对其文档处理的核心，即Notes文档的ID构成机制作了系统剖析．并在此基础上分析了如何在文档复制中运用ID的不同组件以及如何运用API程序访问文档ID等。     

双频抽运提高SBS相位共轭保真度

相位共轭保真度是相位共轭镜技术用于强激光系统中的一个重要指标。采用四波混频加强SBS的方法 ,其相干拍频驱动声子场 ,能提高SBS相位共轭保真度。对于双频单池结构 ,使用列阵相机测量激光束能量远场角分布 ,在SBS转换效率最佳时 ,对相干驱动SBS相位共轭保真度进行了实验研究     

论反射地震偏移成像

对反射地震偏移成像问题进行了分析、对比与探讨，并对各种偏移方法如叠后时间偏移、叠后深度偏移、叠前时间偏移、叠前深度偏移和它们之间在地质效果上的异同进行了讨论。认为，在当前的地面观测记录的质量条件下，叠后时间偏移和叠后深度偏移，叠前时间偏移和叠前深度偏移，都有各自的优势和不足。因此，它们都有应用价值，不是互相排斥，而是互相补充。今后的方向是发展和完善高分辨率和高保真度的偏移成像方法。在这方面还有许多问题要解决。     

Male honor and female fidelity: Implicit cultural scripts that perpetuate domestic violence.

Two studies explored how domestic violence may be implicitly or explicitly sanctioned and reinforced in cultures where honor is a salient organizing theme. Three general predictions were supported: (a) female infidelity damages a man's reputation, particularly in honor cultures; (b) this reputation can be partially restored through the use of violence; and (c) women in honor cultures are expected to remain loyal in the face of jealousy-related violence. Study 1 involved participants from Brazil (an honor culture) and the United States responding to written vignettes involving infidelity and violence in response to infidelity. Study 2 involved southern Anglo, Latino, and northern Anglo participants witnessing a "live" incident of aggression against a woman (actually a confederate) and subsequently interacting with her. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Distributed Context Retrieval and Consistency Control in Pervasive Computing

The challenge of saturating all phases of pervasive service provision with context-aware functionality lies in coping with the complexity of maintaining, retrieving and distributing context information. To efficiently represent and query context information a sophisticated modelling scheme should exist. To distribute and synchronise context knowledge in various context repositories across a multitude of administrative domains, streamlined mechanisms are needed. This paper elaborates on an innovative context management framework that has been designed to cope with free-text and location based context retrieval and efficient context consistency control. The proposed framework has been incorporated in a multi-functional pervasive services platform, while most of the mechanisms it employs have been empirically evaluated.     

Physiological arousal, dissonance, and attitude change: Evidence for a dissonance-arousal link and a "Don't remind me" effect.

Two experiments, with 80 undergraduates, replicated and extended research by R. T. Croyle and J. Cooper (see record 1984-11595-001) indicating that cognitive dissonance involves physiological arousal. In Exp I, Ss wrote counterattitudinal essays under conditions of high or low choice and, to assess arousal effects owing to effort, with or without a list of arguments provided by the experimenter. In high-choice conditions only and regardless of effort, Ss showed both arousal (heightened galvanic skin response) and attitude change. Arousal, however, did not decline following attitude change. The more effortful task (no arguments provided) produced increased arousal but not greater attitude change. In Exp II, the opportunity to change one's attitude following a freely chosen counterattitudinal essay was manipulated. As in Exp I, arousal increased following the essay but did not decline following a postessay attitude change opportunity. When Ss were not given an attitude change opportunity, however, arousal did decline. It is suggested that if dissonance is a drive state, drive reduction typically may be accomplished through gradual cognitive change or forgetting. (47 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The pulse distributed file system

A network of powerful personal computers, linked by a high-speed local area network, is being seen increasingly as an alternative to a traditional centralized time-sharing operating system. The PULSE project is investigating how such a system may be constructed to give the benefits of a self-sufficient personal computer to each user without losing the facilities for communication and sharing of data inherent in centralized systems. In particular, a distributed file system has been built which provides a single global UNIX

1 UNIX is a trademark of Bell Laboratories.

-like hierarchy, with a consistent appearance when accessed from any machine. Replicated copies of files are maintained to improve reliability, increase performance, and enable each machine to run stand-alone, albeit with reduced facilities.