排序方式: 共有48条查询结果,搜索用时 15 毫秒
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Delfino Chamorro-Arenas Giovanna Salgado-Moreno Dr. Liliana Martinez-Mendieta Dr. Leticia Quintero Dr. Beatriz Godínez-Chaparro Prof. Fernando Sartillo-Piscil 《ChemMedChem》2021,16(3):472-476
The design, stereoselective synthesis and in vivo antiallodynic activity of four novel paroxetine analogs, named 3-hydroxy paroxetines (3HPXs), is reported herein. Among the novel synthesized compounds, three showed an antiallodynic effect, while (R,R)-3HPX was found to be 2.5 times more bioactive than (-)-paroxetine itself in neuropathic rats. Consequently, the current investigation not only discloses a novel promising analgesic drug, but also reveals that functionalization at the C3 position of paroxetine could be as effective as the common functionalization at either C4 or within the sesamol group. 相似文献
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以 4′ 氯哌醋甲酯为原料,研究了作为潜在的治疗可卡因滥用症的药物———4 羟基- 5- (4′- 氯苯基 )双环 [4,4, 0]- 1 氮杂癸烷的合成。4′- 氯哌醋甲酯首先用乙酸酐在室温下进行乙酰基化,然后在 -70℃下经二异丙基胺锂(LDA)作用关环得中间产物(±)- threo -2, 4 -二氧代- 5- (4′- 氯苯基)双环[4, 4, 0] -1 氮杂癸烷,产率 60%。中间体先用硼氢化钠在甲醇中室温下选择性地将酮羰基还原,粗产物经V(石油醚)∶V(乙酸乙酯) =1∶1重结晶后,在四氢呋喃中于回流温度下用乙硼烷 四氢呋喃络合物进一步还原酰胺基,得到(±) threo 4α 羟基- 5 -(4′- 氯苯基 )双环[4, 4, 0]- 1 氮杂癸烷,两步产率为 67%。所得α位羟基产物经过Swern氧化,然后在四氢呋喃中在 -78℃下用三(仲丁基)硼氢化钾选择性还原,立体专一性地得到 (±) threo- 4β 羟基- 5 (4′- 氯苯基 )双环 [4, 4, 0]- 1 氮杂癸烷,氧化 还原反应总产率为 70%。 相似文献
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主要研究了β21S钛合金的工艺塑性图,制定了该合金的锻造工艺参数。通过该合金的工艺塑性图,确定变形温度为750-1050℃,最大变形量为75%-80%,终缎温度为700℃。从合金的工艺塑性角度来看,以上 数据是合理的。 相似文献
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A number of purified terminal aliphatic acetylenic hydrocarbons has been copolymerized with liquid sulphur dioxide in the presence of t-butyl hydroperoxide at low temperature. Benzoyl peroxide, hydrogen peroxide and m-chloroperbenzoic acid were ineffective. Neither sulphur dioxide nor t-butyl hydroperoxide alone was capable of polymerizing pure alkynes. Aged (impure) alkynes were copolymerized with sulphur dioxide in the absence of t-butyl hydroperoxide. All resulting alkyne-SO2 copolymers were alternating with 100% trans configuration regardless of the nature of the alkyne, the solvent, or temperature. Several studies were performed to characterize the polysulphones, such as infra-red spectroscopy, 1H and 13C nuclear magnetic resonance spectroscopy, melting point, viscosity, elemental analysis, solubility, film formation and flammability. A mechanism is proposed in which sulphur dioxide homolytically decomposes the organic hydroperoxide into free radicals which initiate the polymerization. The alkyne-SO2 charge transfer complex is formed in solution, and the initiation and propagation steps probably involve this complex in equilbrium with its monomers. 相似文献
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G. G. Skip King Regine Gries Gerhard Gries K. N. Slessor 《Journal of chemical ecology》1995,21(12):2027-2045
(3S, 13R)-3, 13-Dimethylheptadecane [(3S, 13R)-3, 13-dime-17Hy] is the major pheromone component of the western false hemlock looper (WFHL),Nepytia freemani. In comparative gas chromotographic-electroantennographic detection (GC-EAD) analyses of stereoselectively synthesized isomers, 1 pg of (3S, 13R)-dime-17Hy elicited significantly stronger electrophysiological responses by male WFHL antennae than did 1 pg of separately injected (3R, 13R)-, (3R, 13S)- or (3S, 13S)-3, 13-dime-17Hy. In field experiments with individually tested stereoisomers. (3S, 13R)-3, 13-dime-17Hy was the only stereoisomer to attract males, but the four-stereoisomer blend was 3.6 times more attractive. Quaternary and all binary combinations of (3S, 13R)-3, 13-dime-17Hy with the other stereoisomers were equally attractive, suggesting that synergisytic behavioral activity in WFHL resided with either one of (3R, 13R)-, (3R, 13S)-, or (3S, 13S)-3, 13-dime-17Hy. Because optical isomers of (di)methylhydrocarbons do not separate on currently available columns, it remains unknown whether female WFHL also produce a four-stereoisomer pheromone blend. Substitutionality of pheromone stereoisomers without loss of behavioural activity has not previously been reported, but favorably compares with the concept of pheromone redundancy that was first suggested for the multiple pheromone component blend of the cabbage looper moth,Trichoplusia ni. 相似文献
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4—烃基—4—硝基乙烯基—2,3—苯并吡喃酮的立体选择合成 总被引:1,自引:0,他引:1
报道了4-烃基-4-硝基乙烯基-2,3-苯并吡喃酮的立体选择硝基乙烯反应,研究了反应温度对产率的影响,发现低温时反应很不完全,但当温度升至0℃时,用^1HNMR光谱确定了产物双键的立体构型,并初步探讨了反应历程。 相似文献
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Supporting Information for this article is available on the WWW under http://www.wiley‐vch.de/home/asc Cyclopropanation of trisubstituted alkenes with diazoacetates can be achieved with remarkabe syn‐selectivity when the polymeric ruthenium(I) complex [Ru2(CO)4(μ‐OAc)2]n is used as catalyst. 相似文献