High-Fat Diet Aggravates Cerebral Infarct,Hemorrhagic Transformation and Neuroinflammation in a Mouse Stroke Model

Background: Stroke in context of type 2 diabetes (T2D) is associated with a poorer outcome than in non-diabetic conditions. We aimed at creating a new reproducible mouse model of stroke in impaired glucose tolerance conditions induced by high-fat diet. Methods: Adult C57BL6 mice were fed for 2 months with either normal diet (ND) or high-fat diet (HFD). We used a model of Middle Cerebral Artery Occlusion (MCAO) for 90 min. Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) were used to assess pre-diabetic status. Brain infarct volume, hemorrhagic transformation (HT) as well as systemic and cerebral inflammatory markers were evaluated. Results: HFD was associated with an increased body weight and glycemia following OGTT. The HFD group presented a significant increase in brain infarct volume (38.7 (IQR 30–46.7%) vs. 28.45 (IQR 21–30%); p = 0.016) and HT (HFD: 2 (IQR 1–5) vs. ND: 0 (IQR 0–1); p = 0.012) and higher levels of IL-6 and MCP-1 in infarcted hemisphere compared to the ND group. Conclusion: Two months of HFD in adult mice were sufficient to alter the lipid profile and the control of hyperglycemia. These metabolic perturbations were significantly associated with increased infarct volume and hemorrhagic complications.     

浅析混凝土搅拌站的防雷

近年来,我市因雷击而导致搅拌站系统瘫痪停产、影响工程进度的事件时有发生,在针对混凝土搅拌站配料秤的实际检定工作中,也常发现配料秤的称重传感器因雷击损坏而影响计量准确性。因此,对混凝土搅拌站防雷的研究具有重要意义。本文阐述了雷电对混凝土搅拌站的主要危害,分析了混凝土搅拌站常见的雷击原因及其防护措施,旨在引起生产方、安装方以及使用方对混凝土搅拌站防雷的共同重视。     

Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke

Ischemic and hemorrhagic strokes are associated with severe functional disability and high mortality. Except for recombinant tissue plasminogen activator, therapies targeting the underlying pathophysiology of central nervous system (CNS) ischemia and hemorrhage are strikingly lacking. Sur1-regulated channels play essential roles in necrotic cell death and cerebral edema following ischemic insults, and in neuroinflammation after hemorrhagic injuries. Inhibiting endothelial, neuronal, astrocytic and oligodendroglial sulfonylurea receptor 1–transient receptor potential melastatin 4 (Sur1–Trpm4) channels and, in some cases, microglial K_ATP (Sur1–Kir6.2) channels, with glibenclamide is protective in a variety of contexts. Robust preclinical studies have shown that glibenclamide and other sulfonylurea agents reduce infarct volumes, edema and hemorrhagic conversion, and improve outcomes in rodent models of ischemic stroke. Retrospective studies suggest that diabetic patients on sulfonylurea drugs at stroke presentation fare better if they continue on drug. Additional laboratory investigations have implicated Sur1 in the pathophysiology of hemorrhagic CNS insults. In clinically relevant models of subarachnoid hemorrhage, glibenclamide reduces adverse neuroinflammatory and behavioral outcomes. Here, we provide an overview of the preclinical studies of glibenclamide therapy for CNS ischemia and hemorrhage, discuss the available data from clinical investigations, and conclude with promising preclinical results that suggest glibenclamide may be an effective therapeutic option for ischemic and hemorrhagic stroke.     

积极降压对脑小血管病防治策略的影响

2017年,美国心脏病学会和美国心脏协会提出将高血压诊断标准降为130/80 mm Hg (1 mm Hg=0. 133 kPa),这与其他指南有所不同。降压治疗的核心目标在于靶器官的保护,近年来降压治疗与脑小血管病预防的相关问题日益受到临床重视。目前研究结果表明,降压治疗对腔隙性卒中患者的二级预防以及白质病变进展的预防可能有一定积极意义,但确切的降压目标值并未确定。血压与临床结局可能呈现J型关系,血压过低或过高可能均有害,而取得最大获益的降压目标有待进一步探索。     

直线电机抽油机与游梁式抽油机性能对比

攻克了直线电机大推力的关键技术,研制成功了具有国际领先水平的直线电机抽油机。这种抽油机最大特点是改变了过去各种抽油机将电能转变为旋转运动,再通过机械方式转变为直线往复运动的方式,通过变频和控制直接将电能转变为直线往复运动。与游梁式抽油机相比,直线电机抽油机不但提高了机械效率,而且能够实现抽汲参数的无级调整,进而能够根据抽油的需要调整悬点运动规律,具备智能化控制和远程监控的有利条件。     

浅述设备对PCB微孔电镀镀液更新之影响

分析了设备对PCB电镀过程中孔中镀液更新之影响,为有效地利用设备条件改善孔中镀液的更新提供了一些方法及理论数据。     

一种构思新颖的抽油机设计方案

介绍了一种与现有抽油机结构完全不同的机 电一体化抽油机 ,它主要由往复滚筒提升总成、减速器总成、蓄能助启系统及电磁自动控制和动力系统组成。其特点是采用机 电一体化设计 ,充分利用飞轮的蓄能及与电磁自动控制器的相互配合来控制电磁离合器的激磁电流和电动机的电力输入 ,实现上冲程时通电、下冲程时断电的工作方式。该机体积小 ,结构紧凑 ,适应性强 ,能满足抽油井超长冲程和节能的要求     

Effects of stimulus emotionality and sentence generation on memory for words in adults with unilateral brain damage.

Does sentence generation and/or stimulus emotionality enhance verbal memory in patients with neurological impairment? This question was addressed by testing 40 patients with unilateral stroke (20 with left-brain and 20 with right-brain damage) and 20 healthy control participants for recall and recognition of 48 target words. During encoding, emotional and nonemotional words were either presented in sentences (read condition) or used to form sentences (generate condition). Both word emotionality and generative processing improved memory performance in all groups. The authors suggest that a similar influence (i.e., cognitive activation) underlies both of these memory-enhancing effects, although the putative origins of the 2 effects are quite different. Neuropsychological underpinnings and clinical implications of these phenomena are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effective lightning protection schemes for distribution line

The causes of lightning outage are subdivided into direct lightning strokes and induced lightning strokes, which are identified by the characteristics of the lightning overvoltage. In the past, lightning protection devices were directed mainly toward the latter, and attention has been focused on the installation of lightning protection devices, ground wires, and reinforcement of insulators. However, lightning outages continue to occur. Thus it is extremely important to clarify the fault characteristics of lightning surges and to study the effectiveness of various lightning protection devices by considering both direct lightning stroke and induced lightning stroke in order to prevent lightning outage in the future. In this research, the electromagnetic transients program (EMTP) has been applied to the direct lightning stroke, and the induced lightning outage analysis program for multiple conductor systems has been applied to the induced lightning stroke to study the effectiveness of lightning protection devices provided by combination of various lightning protection devices. The most effective lightning protection schemes are analyzed and evaluated based on verification tests on the full scale models as well as economic considerations.     

基于电报编码的"电子喉"系统

本文介绍一种能够解决有语言障碍的人汉语发音问题的计算机软件系统，此系统采用电报和五笔画编码方案作为汉字输入方法，自建了一套汉字录入和检索体系，并利用Microsoft公司的Speech SDK4.0和Concatenated Text-to-Speech Engine建立了专用的语音库，本系统使得有语言障碍的人可以与其他正常人之间进行正常的交流，从而避免了使用哑语带来的不便。