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991.
Multi-objective optimal reactive power flow including voltage security and demand profile classification 总被引:2,自引:0,他引:2
R. He G.A. Taylor Y.H. Song 《International Journal of Electrical Power & Energy Systems》2008,30(5):327-336
This paper proposes a method to optimize reactive power flow (ORPF) with regard to multiple objectives while maintaining system voltage security across a time-domain. Compromise programming is employed in the ORPF formulation, which is designed to minimize both losses and payment for the reactive power service in the framework of the UK daily balancing market. In coordination with ORPF, continuation power flow (CPF) is applied to evaluate and maintain the voltage security margin of the system. Prior to the optimisation procedure, the related control parameters can be grouped with the aid of a load classification method in order to simplify the control actions. During the optimisation, through the application of both ORPF and CPF, multi-objective optimisation can be achieved with voltage security at an acceptable level. The Ward and Hale 6-bus system and a 60-bus UK test system are presented to illustrate the application of the proposed modeling framework. 相似文献
992.
Emily R. Featherston Hannah R. Rose Molly J. McBride Ellison M. Taylor Prof. Amie K. Boal Prof. Joseph A. Cotruvo Jr. 《Chembiochem : a European journal of chemical biology》2019,20(18):2360-2372
Lanthanide (Ln)-dependent methanol dehydrogenases (MDHs) have recently been shown to be widespread in methylotrophic bacteria. Along with the core MDH protein, XoxF, these systems contain two other proteins, XoxG (a c-type cytochrome) and XoxJ (a periplasmic binding protein of unknown function), about which little is known. In this work, we have biochemically and structurally characterized these proteins from the methyltroph Methylobacterium extorquens AM1. In contrast to results obtained in an artificial assay system, assays of XoxFs metallated with LaIII, CeIII, and NdIII using their physiological electron acceptor, XoxG, display Ln-independent activities, but the Km for XoxG markedly increases from La to Nd. This result suggests that XoxG′s redox properties are tuned specifically for lighter Lns in XoxF, an interpretation supported by the unusually low reduction potential of XoxG (+172 mV). The X-ray crystal structure of XoxG provides a structural basis for this reduction potential and insight into the XoxG–XoxF interaction. Finally, the X-ray crystal structure of XoxJ reveals a large hydrophobic cleft and suggests a role in the activation of XoxF. These studies enrich our understanding of the underlying chemical principles that enable the activity of XoxF with multiple lanthanides in vitro and in vivo. 相似文献
993.
Angeliki-Sofia Foscolos Prof. Ioannis Papanastasiou Prof. Andrew Tsotinis Prof. Martin C. Taylor Prof. John M. Kelly 《ChemMedChem》2019,14(13):1227-1231
The synthesis and pharmacological evaluation of C1-substituted adamantane hydrazones, their C2-substituted isomers, and C1-substituted adamantane furanoic carboxamides is described. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity. The most active adduct with the best selectivity in this study was found to be the phenylacetoxy hydrazone 1 b (2-[4-(tricyclo[3.3.1.13,7]dec-1-yl)phenyl]-N′-[(5-nitrofuran-2-yl)methylene]acetohydrazide; EC50=11±0.9 nm , SITb=770). 相似文献
994.
995.
DeCarlos E. Taylor 《Journal of the American Ceramic Society》2015,98(10):3308-3318
The shock Hugoniot of boron carbide, from 0 to 80 GPa, has been obtained using first principles quantum mechanics (density functional theory) and molecular dynamics simulation. The Hugoniot for six different structures which vary by structure or stoichiometry were computed and compared to experimental data. The effect of stoichiometry, and structural variation within a given stoichiometry, are shown to have marked effects on the shock properties with some compositions displaying bilinear behavior in the computed shock velocity‐particle velocity profiles while others show a continuous Hugoniot curve with no evidence of a phase transition over the pressure range considered in this work. Two structures, B12(CBC) and B11Cp(CCB), have predicted phase transition pressures lying within the 40–50 GPa range suggested experimentally. It is shown that the phase transition is driven by deformation of the 3‐atom chain within the boron carbide crystal structure which induces a discontinuous volume change at the critical shock pressure. The effect of defects, in the form of chain vacancies, on the shock response is presented and the ability of shear to significantly lower the phase transition pressure, in accord with experimental observation, is demonstrated. 相似文献
996.
Avnish Verma Ayse Orme Merve Vytautas Remekevi
ius Pola Sobiecka Luke Taylor Scott Lawton Ben P Jones Elena Polycarpou Jason Bennett Brian Rooney 《International journal of molecular sciences》2021,22(5)
Cocaine is one of the most widely abused illicit drugs worldwide and has long been recognised as an agent of cardiac dysfunction in numerous cases of drug overdose. Cocaine has previously been shown to up-regulate cytoskeletal rearrangements and morphological changes in numerous tissues; however, previous literature observes such changes primarily in clinical case reports and addiction studies. An investigation into the fundamental cytoskeletal parameters of migration, adhesion and proliferation were studied to determine the cytoskeletal and cytotoxic basis of cocaine in cardiac cells. Treatment of cardiac myocytes with cocaine increased cell migration and adhesion (p < 0.05), with no effect on cell proliferation, except with higher doses eliciting (1–10 μg/mL) its diminution and increase in cell death. Cocaine downregulated phosphorylation of cofilin, decreased expression of adhesion modulators (integrin-β3) and increased expression of ezirin within three hours of 1 μg/mL treatments. These functional responses were associated with changes in cellular morphology, including alterations in membrane stability and a stellate-like phenotype with less compaction between cells. Higher dose treatments of cocaine (5–10 μg/mL) were associated with significant cardiomyocyte cell death (p < 0.05) and loss of cellular architecture. These results highlight the importance of cocaine in mediating cardiomyocyte function and cytotoxicity associated with the possible loss of intercellular contacts required to maintain normal cell viability, with implications for cardiotoxicity relating to hypertrophy and fibrogenesis. 相似文献
997.
Multi-drug-resistant bacteria are becoming more prevalent, and treating these bacteria is becoming a global concern. One alternative approach to combat bacterial resistance is to use antimicrobial (AMPs) or host-defense peptides (HDPs) because they possess broad-spectrum activity, function in a variety of ways, and lead to minimal resistance. However, the therapeutic efficacy of HDPs is limited by a number of factors, including systemic toxicity, rapid degradation, and low bioavailability. One approach to circumvent these issues is to use lipidation, i.e., the attachment of one or more fatty acid chains to the amine groups of the N-terminus or a lysine residue of an HDP. In this review, we examined lipidated analogs of 66 different HDPs reported in the literature to determine: (i) whether there is a link between acyl chain length and antibacterial activity; (ii) whether the charge and (iii) the hydrophobicity of the HDP play a role; and (iv) whether acyl chain length and toxicity are related. Overall, the analysis suggests that lipidated HDPs with improved activity over the nonlipidated counterpart had acyl chain lengths of 8–12 carbons. Moreover, active lipidated peptides attached to short HDPs tended to have longer acyl chain lengths. Neither the charge of the parent HDP nor the percent hydrophobicity of the peptide had an apparent significant impact on the antibacterial activity. Finally, the relationship between acyl chain length and toxicity was difficult to determine due to the fact that toxicity is quantified in different ways. The impact of these trends, as well as combined strategies such as the incorporation of d- and non-natural amino acids or alternative approaches, will be discussed in light of how lipidation may play a role in the future development of antimicrobial peptide-based alternatives to current therapeutics. 相似文献
998.
A NEW OIL SEEPAGE IN THE OMAN MOUNTAINS AND ITS GEOLOGICAL,GEOCHEMICAL AND PETROLEUM SYSTEMS CONTEXT
Mohammed Al Kindi Mohammed Al-Ghammari Alan Heward Paul Taylor George Siavalas 《Journal of Petroleum Geology》2022,45(1):5-28
A minor natural oil seepage is described from an unlikely setting in the Oman Mountains. The host rocks are fractured pelagic limestones of the lower member of the Triassic – Lower Jurassic Matbat Formation of the Hamrat Duru Group in the lower part of the allochthonous Hawasina Complex. This paper summarises Oman's established oil families and documents previously recorded oil seepages as context for describing the new seepage, its geochemistry, and possible source rock. The seep oil is different to those known from Oman's oil fields and probably derived from a poor quality, Mesozoic clastic source rock containing a mix of terrigenous and marine organic matter. The most likely source appears to be the Toarcian turbiditic upper member of the Matbat Formation, equivalent to the clastic Mafraq Formation of the Arabian Platform. The occurrence of source rocks in the allochthonous sediments of the NeoTethyan Hawasina Basin has been suspected previously, though their commercial significance remains to be established. 相似文献
999.
Dr. James P. Holt-Martyn Dr. Rasheduzzaman Chowdhury Dr. Anthony Tumber Dr. Tzu-Lan Yeh Dr. Martine I. Abboud Dr. Kerstin Lippl Dr. Christopher T. Lohans Dr. Gareth W. Langley William Figg Jr. Dr. Michael A. McDonough Prof. Dr. Christopher W. Pugh Prof. Dr. Peter J. Ratcliffe Prof. Dr. Christopher J. Schofield 《ChemMedChem》2020,15(3):270-273
The 2-oxoglutarate-dependent hypoxia inducible factor prolyl hydroxylases (PHDs) are targets for treatment of a variety of diseases including anaemia. One PHD inhibitor is approved for use for the treatment of renal anaemia and others are in late stage clinical trials. The number of reported templates for PHD inhibition is limited. We report structure–activity relationship and crystallographic studies on a promising class of 4-hydroxypyrimidine-containing PHD inhibitors. 相似文献
1000.