Design,Synthesis and Biological Evaluation of Steroidal Glycoconjugates as Potential Antiproliferative Agents

To systematically evaluate the impact of neoglycosylation upon the anticancer activities and selectivity of steroids, four series of neoglycosides of diosgenin, pregnenolone, dehydroepiandrosterone and estrone were designed and synthesized according to the neoglycosylation approach. The structures of all the products were elucidated by NMR analysis, and the stereochemistry of C20-MeON-pregnenolone was confirmed by crystal X-ray diffraction. The compounds′ cytotoxicity on five human cancer cell lines was evaluated using a Cell Counting Kit-8 assay, and structure–activity relationships (SAR) are discussed. 2-deoxy-d -glucoside 5 k displayed the most potent antiproliferative activities against HepG2 cells with an IC₅₀ value of 1.5 μM. Further pharmacological experiments on compound 5 k on HepG2 cells revealed that it could cause morphological changes and cell-cycle arrest at the G0/G1 phase and then induced the apoptosis, which might be associated with the enhanced expression of high-mobility group Box 1 (HMGB1). Taken together, these findings prove that the neoglycosylation of steroids could be a promising strategy for the discovery of potential antiproliferative agents.     

The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products

Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.     

High-performance Multicrystalline Silicon Ingots Assisted by Recycled Multicrystalline Silicon Block Tailing as Seeds

Silicon - Nowadays, casted multicrystalline silicon is the most important material in photovoltaic industry. In order to reduce the cost of silicon ingots, the recycle of silicon ingot tailings is...     

低电阻率耐候性导电碳浆的制备

研究石墨和炭黑的形貌、粒径以及配比对导电碳浆电阻率的影响,分析聚酯和有机硅改性聚酯制备导电碳浆耐候性的差异及原因.试验表明:D90为12.8μm的不等轴鳞片状石墨SFG-10和高度链状团聚炭黑350 G的质量比为7:3时制备的导电碳浆电阻率低,为4×10-2Ω·cm,且硬度H>4;在高低温、高湿和紫外光照射试验条件下,聚酯和有机硅改性聚酯制备导电碳浆电阻值最大变化率分别为36.7％和9.5％,有机硅改性聚酯能显著提高导电碳浆的耐候性.     

电能计量箱用智能锁具的研究与应用

随着用电信息采集建设的深入开展,电网公司对各类电能计量资产的精细化管理需求日益提高。传统机械锁具在资产管理、安全管理和业务管理等方面存在不足,针对传统机械锁具在应用上存在的问题,本文提出了融合物联网技术、无线传输技术及云计算技术的电能计量箱用智能锁具应用方案。通过研究智能锁具、云平台以及APP,成功帮助电网公司实现电能计量资产的智能化管控和精细化管理,有效提升了企业管理水平及服务质量,促进了电网安全、可靠、稳定发展。     

多自由度电机的发展及关键技术综述

多自由度电机可以实现空间中的复杂运动,且具有结构简单、精确度高等优势,在机器人仿生关节、机械手臂及工业制造业上具有广阔的应用前景。对多自由度电机的背景、基本原理及技术优势进行了相关叙述。按照驱动机理的不同将多自由度电机进行分类,并对当前多自由度电机的国内外研究现状进行了总结。此外,基于多自由度电机的运动特点,对电机控制过程中的位置检测技术和运动控制策略进行了相关分析。最后,从多自由度电机的结构、控制体系、材料及制造工艺等方面进行了相关的叙述,对多自由度电机的发展趋势进行预测。通过对多自由度电机的研究与分析,为其未来的发展提供参考。     

Concepts,processing, and recent developments in encapsulating essential oils

By the virtue of their olfactory, physicochemical, and biological characteristics, essential oils (EOs) have drawn wide attention as additives in daily chemicals like perfume or personal care products. Nevertheless, they are physicochemically unstable and susceptible to degradation or loss. Microencapsulation offers a feasible strategy to stabilize and prolong release of EO. This review summarizes the recognized benefits and functional properties of various preparation and characterization methods, wherein innovative fabrication strategies and their formation mechanisms are especially emphasized. Progress in combining detecting/measuring technologies with kinetic modelling are discussed, to give an integral approach of controlling the dynamic release of encapsulated EOs. Moreover, new development trends of EOs capsules are also highlighted.     

热氧老化EPR电缆绝缘局部放电特性及劣化机理

为了探究热氧老化后乙丙橡胶电缆绝缘的局部放电特性及劣化机理,文中通过典型柱–板电极对不同老化程度的乙丙橡胶试样进行了局部放电试验,并对其放电发展特性和材料理化性质进行了分析。结果表明:放电起始电压和闪络电压均随绝缘老化程度的提高而降低;根据放电过程中放电特征量的变化规律,可将放电过程划分为4个阶段:起始阶段、发展阶段、持续阶段、预闪络阶段,且不同老化程度试样的PRPD谱图在各阶段呈现出特定形状;老化后的试样表面气化或气体解吸附、内部添加剂成分析出导致试样表面出现"沟壑区"、白色块状物和"微孔",分子结构中的羰基等含氧基团、聚乙烯和聚丙烯等自由基数量的增加是乙丙橡胶绝缘在热氧老化后更易出现局部放电的关键原因。     

基于自适应粒子群优化LSSVM的变压器油中溶解气体浓度预测

为了实现油浸式变压器油中溶解气体的预测,进而达到变压器状态预警、降低事故发生率的目的,本文将自适应粒子群优化算法(IDP SO)和最小二乘支持向量机(LSSVM)相结合,建立变压器油中溶解气体预测模型.利用IDP SO算法基于种群的并行搜索策略特点来自适应迭代搜索最优的目标函数值,寻找LSSVM模型中的参数ξ、C和σ的最优取值,克服了应用传统支持向量机算法进行预测时凭主观经验选择参数对模型泛化能力和预测性能的影响.利用国网陕西省电力公司某变电站采集变压器油色谱数据进行实例验证,结果表明基于IDP SO优化的LSSVM算法具有较好的模式跟踪性能,且能够有效提高变压器油中溶解气体预测的预测精度.     

Nickel-Carnosine complex:A new carrier for enzymes immobilization by affinity adsorption

Immobilization is an effective method to promote the application of enzyme industry for improving the stability and realizing recovery of enzyme.To some extent,the performance of immobilized enzyme depends on the choice of carrier material.Therefore,the development of new carrier materials has been one of the key issues concerned by enzyme immobilization researchers.In this work,a novel organic-inorganic hybrid material,nickel-carnosine complex (NiCar),was synthesized for the first time by solvothermal method.The obtained NiCar exhibits spherical morphology,hierarchical porosity and abun-dant unsaturated coordination nickel ions,which provide excellent anchoring sites for the immobiliza-tion of proteins.His-tagged organophosphate-degrading enzyme (OpdA) and ω-transaminase (ω-TA)were used as model enzymes to evaluate the performance of NiCar as a carrier.By a simple adsorption process,the enzyme molecules can be fixed on the particles of NiCar,and the stability and reusability are significantly improved.The analysis of protein adsorption on NiCar verified that the affinity adsorp-tion between the imidazole functional group on the protein and the unsaturated coordination nickel ions on NiCar was the main force in the immobilization process,which provided an idea way for the develop-ment of new enzyme immobilization carriers.