Retrograde Amnesia Induced by Drugs Acting on Different Molecular Systems.

The gamma aminobutyric acid-A (GABAA) agonist, muscimol, the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist, D-2-amino-5-phosphonopentanoic acid (AP5), and the inhibitor of the extracellularly regulated kinases (ERKs), UO 126, cause retrograde amnesia when administered to the hippocampus. In the present study, the authors found that they all cause retrograde amnesia for 1-trial inhibitory avoidance, not only when infused into the dorsal CA1 region of the hippocampus, but also when infused into the basolateral amygdala or the entorhinal, parietal, and posterior cingulate cortices. The posttraining time course of the effect of each drug was, however, quite different across brain structures. Thus, in all of them, NMDA receptors and the ERK pathway are indispensable for memory consolidation, and GABAA receptor activation inhibits memory consolidation: but in each case, their influence is interwoven differently. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Two-Dimensional Physical and Numerical Modeling of a Pile-Supported Earth Platform over Soft Soil

This paper focuses on the mechanisms occurring in a granular earth platform over soft ground improved by rigid piles. Two-dimensional physical model experiments were performed using the Schneebeli’s analogical soil to investigate the load transfer mechanisms by arching and the settlement reduction and homogenization. Experimental outputs are compared to results obtained on a numerical model using a plane strain continuum approach. The impact of the constitutive model complexity to simulate the platform material behavior was first assessed, but no large difference was recorded. As far as the proposed model, which takes the main features of the observed behavior satisfactorily into account, the numerical procedure could be validated and the parametric studies extended numerically. Both approaches of this study underlined the main geometrical and geotechnical parameters which should inevitably be taken into account in a simplified design method, namely the capping ratio, the platform height, and the platform material shear strength.     

Final Drying of Whole Milk Powder in Vibrated-Fluidized Beds

Vibro-fluidized beds are widely used in drying sticky powders and agglomerated materials as milk powder. Using a vibro-fluidized laboratory scale dryer, this work is aiming at analyzing preliminarily the effect of its operational variables on the drying kinetics and characteristics of whole milk powder. The full-factorial design technique with three replications at the central point has been employed to generate data and correlations to quantify the effect of inlet air temperature, air flow rate, and vibration bed amplitude on the drying curves and the milk powder properties related to its faster reconstitution in water (as tapped density, Hausner cohesion ratio, agglomerate size distribution, and internal pore concentration). Results obtained are analyzed and discussed to identify the adequate operation condition for final drying whole milk powder in vibro-fluidized beds, assuring a high product quality.     

Efficient primal-dual heuristic for a dynamic location problem

In this paper the dynamic location problem with opening, closure and reopening of facilities is formulated and an efficient primal-dual heuristic that computes both upper and lower limits to its optimal solution is described. The problem here studied considers the possibility of reconfiguring any location more than once over the planning horizon. This problem is NP-hard (the simple plant location problem is a special case of the problem studied). A primal-dual heuristic based on the work of Erlenkotter [A dual-based procedure for uncapacitated facility location. Operations Research 1978;26:992–1009] and Van Roy and Erlenkotter [A dual-based procedure for dynamic facility location. Management Science 1982;28:1091–105] was developed and tested over a set of randomly generated test problems. The results obtained are quite good, both in terms of the quality of lower and upper bounds calculated as in terms of the computational time spent by the heuristic. A branch-and-bound procedure that enables to optimize the problem is also described and tested over the same set of randomly generated problems.     

XPS studies of directly fluorinated HDPE: problems and solutions

X-ray photoelectron spectroscopy (XPS) applied to the study of fluorinated polymer surfaces presents several problems related both to peak assignment and to degradation. In this work, we analyse extensively the question of XPS peak assignments in this kind of surfaces. We conclude that in this kind of surfaces using binding energy differences between fluorine and carbon is better than using absolute binding energies. Also a useful relation between fluorine photoelectron energy vs. polymer composition expressed through the atomic ratio fluorine/carbon (F/C) was found. A protocol for data treatment is proposed and applied to a XPS study of the degradation induced by X-ray on high-density polyethylene surfaces modified by direct fluorination. Results obtained for the degradation, namely the atomic ratio F/C obtained by two different methods, combined with angle resolved X-ray photoelectron spectroscopy (ARXPS) were used to study the fluorine concentration profile in depth, producing self-consistent results.     

Residual Stress Evolution in Repair Welds

Abstract: The aim of this paper is to study the influence of the repair procedure on the evolution of residual stress distribution in butt welds. C-Mn steel coupon plates of 11 mm thickness were prepared, subjected to stress relief heat treatment and welded with two beads, using the gas metal arc welding process. After the deposition of two weld beads, two successive repair welds were made on the middle length of the second bead. Longitudinal and transverse residual stresses were measured in the vicinity of the weld, after deposition of the two weld beads and after each repair weld. Residual stress evaluation was conducted using an X-ray diffraction method. The repair welds caused a decrease in magnitude of the initial longitudinal residual welding stresses, and an increase of the transverse residual stress magnitude, in tension at points within the repair length, and in compression at points outside the repair length.     

The Effect of Reagents on Ultrafine Iron Ore Vacuum Filtration

Continuous vacuum filters normally carry out the final removal of water from iron ore products. The objective of this investigation is to check the possibility of enhancing the industrial performance of a horizontal belt filter by adding one flocculant and two surfactants to the filtration feed slurry. The mineral sample came from the Iron Quadrangle (State of Minas Gerais, Brazil). X-ray diffraction showed a predominance of hematite and small amounts of quartz and goethite. The filtration tests were performed at laboratory scale using a modified Büchner funnel apparatus, which was connected to a scale/computer system. The results indicated: a) the best filtration condition was achieved near the zero charge condition; b) cake moisture, cake porosity, cake formation time and the specific cake resistance were pronouncedly influenced by the flocculant addition; and c) surfactants tested were not able to significantly reduce the cake moisture.     

Effects of load modeling in security constrained OPF studies

Results of computational experiments carried out on an adaptation of the AEP/IEEE 30 bus test system are reported. Some selected buses were modeled using an exponential type of load model. Three cases are considered. In the first case it is assumed that the specified load at modeled buses is obtained with unity voltage. In the second case it is assumed that the transformer taps have been adjusted to give all industrial-type consumers one per unit at the low-voltage panel when the high-side voltage corresponds to the standard optimal power flow (OPF) solution. The third case differs from the second in that the specified power demand is assumed to take place when the high-side voltages correspond to the intact case of the standard security constrained OPF solution. It is concluded that a decrease in fuel cost can be obtained in some instances when load models are incorporated in security constrained OPF studies during contingencies only. In situations where a decrease in fuel cost is obtained in this manner, the magnitude of decrease depends on the total percentage of load fed by fixed tap transformers and the sensitivity of these loads to modeling     

Protecting against key-exposure: strongly key-insulated encryption with optimal threshold

Key-insulated encryption schemes use a combination of key splitting and key evolution to protect against key exposure. Existing schemes, however scale poorly, having cost proportional to the number t of time periods that may be compromised by the adversary, and thus are practical only for small values of t. Yet in practice t might be large. This paper presents a strongly key-insulated encryption scheme with optimal threshold. In our scheme, t need not be known in advance and can be as large as one less than the total number of periods, yet the cost of the scheme is not impacted. This brings key-insulated encryption closer to practice. Our scheme is based on the Boneh-Franklin identity-based encryption (IBE) scheme [9], and exploits algebraic properties of the latter. Another contribution of this paper is to show that (not strongly) key-insulated encryption with optimal threshold and allowing random-access key updates (which our scheme and all others known allow) is equivalent to a restricted form of IBE. This means that the connection between key-insulated encryption and IBE is not accidental. Supported in part by NSF grants CCR-0098123, ANR-0129617 and CCR-0208842, and by an IBM Faculty Partnership Development Award. Supported in part by an NSF graduate fellowship.     

Renewable energy systems: A societal and technological platform

Today, the analysis of renewable energy places the emphasis on the technological and economic attributes with social and environmental impact assessment providing for a rather static, narrow frame of analysis. The participation and response of social actors and other stakeholders is usually of a traditional type, with consultation documents and public meetings, collection of complaints and suggestion schemes. This often encourages parochialism and an over-concentration on relatively trivial issues. It is, therefore, imperative to establish a new participatory planning platform to incorporate the wider socio-economic aspects of renewable energy systems and to provide for an operational analytical decomposition of them. In this work the issue of decomposition analysis is clarified, and a new agenda for the societal and technological decomposition analysis of renewable energy systems is developed. A case study is disclosed to present the relevance of the established platform for integrated (renewable) energy systems planning. Innovative aspects comprise of the simultaneous inclusion of decision analysis and social acceptance methods and tools in concert with the related public participation techniques.