Investigation of hydrogen and power co-generation based on direct coal chemical looping systems

This paper evaluates hydrogen and power co-generation based on direct coal chemical looping systems with total decarbonization of the fossil fuel. As an illustrative example, an iron-based chemical looping system was assessed in various plant configurations. The designs generate 300–450 MW net electricity with flexible hydrogen output in the range of 0–200 MW_th (LHV). The capacity of evaluated plant concepts to have a flexible hydrogen output is an important aspect for integration in modern energy conversion systems. The carbon capture rate of evaluated concepts is almost total (>99%). The paper presents in details evaluated plant configurations, operational aspects as well as mass and energy integration issues. For comparison reason, a syngas-based chemical looping concept and Selexol^®-based pre-combustion capture configuration were also presented. Direct coal chemical looping configuration has significant advantages compared with syngas-based looping systems as well as solvent-based carbon capture configurations, the more important being higher energy efficiency, lower (or even zero) oxygen consumption and lower plant complexity. The results showed a clear increase of overall energy efficiency in comparison to the benchmark cases.     

Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis

Bone marrow-derived mesenchymal stromal cells (MSCs) are major players in regenerative therapies for wound healing via their paracrine activity, mediated partially by exosomes. Our purpose was to test if MSC-derived exosomes could accelerate wound healing by enhancing the biological properties of the main cell types involved in the key phases of this process. Thus, the effects of exosomes on (i) macrophage activation, (ii) angiogenesis, (iii) keratinocytes and dermal fibroblasts proliferation and migration, and (iv) the capacity of myofibroblasts to regulate the turnover of the extracellular matrix were evaluated. The results showed that, although exosomes did not exhibit anti-inflammatory properties, they stimulated angiogenesis. Exposure of keratinocytes and dermal (myo)fibroblasts to exosomes enhanced their proliferation and migratory capacity. Additionally, exosomes prevented the upregulation of gene expression for type I and III collagen, α-smooth muscle actin, and MMP2 and 14, and they increased MMP13 expression during the fibroblast–myofibroblast transition. The regenerative properties of exosomes were validated using a wound healing skin organotypic model, which exhibited full re-epithelialization upon exosomes exposure. In summary, these data indicate that exosomes enhance the biological properties of keratinocytes, fibroblasts, and endothelial cells, thus providing a reliable therapeutic tool for skin regeneration.     

Influence of Dicyclopentadiene Co-Polymers on the Hardening Processes and Properties of Portland Cement Composites

Dicyclopentadine (DCPD) polymers can be used for the manufacture of self healing materials due to their ability to form in the presence of a catalyst a highly cross-linked polycyclopendiene. The DCPD polymers selected for this work contain also another constituent sequence (maleic anhydride), therefore in this paper we assess also the possibility to use it for a potential self healing process. In this paper is presented the influence of two types of (DCPD) co-polymers based on maleic anhydride copolymers on the hardening processes and main properties of portland cement pastes and mortars, as a first step in the development of a self-healing cementitious composite. The properties (mechanical strengths and volume variations) of the cementitious composites with DCPD co-polymers are influenced by the chemical structure of the obtained compounds and curing medium (dry or humid air). The mortars with AM (maleic anhydride/dicyclopentadiene co-polymer) did not develop any mechanical strength due to an important swelling phenomenon determined by the hydrolysis of anhydride groups and sterical modifications in chain structures. The presence of APA (AM copolymer modified with p-amino phenyl acetic acid) decreases the compressive strengths but has a less important effect on the flexural strength. The APA polymer-cement interaction consists in a chelatization process involving the nitrogen atoms and hydrogen bonding of carboxyl groups providing, in this case, a good cohesion of the composite material. For both polymers a delay in cement hydration was noticed at early ages as well as the formation of organo-mineral phases.     

A blended learning Approach to teaching foreign policy: Student experiences of learning through face-to-face and online discussion and their relationship to academic performance

This article presents research on students’ experiences of learning through a blend of face-to-face and online discussion. The participants in our study were students enrolled in a foreign policy course at a major Australian university. Students’ conceptions of learning through discussion, and their approaches to both face-to-face and online discussion, were elicited through open-ended questionnaires and semi-structured interviews. Students’ responses to both open-ended questionnaires and interviews were analysed using a phenomenographic framework. Qualitative variations in students’ conceptions and approaches were categorised and were found to form a hierarchy. Subsequent quantitative analysis found associations between students’ conceptions of learning through discussion, their approaches to both face-to-face and online discussion and their academic performance (as indicated by the final mark for the course). Implications for teaching and further research are discussed.     

Early warning systems for sovereign debt crises: The role of heterogeneity

Sovereign default models that differ in their treatment of unobservable country, regional and time heterogeneities are systematically compared. The analysis is based on annual data over the 1983-2002 period for 96 developing economies. Inference-based criteria and parameter plausibility overwhelmingly favour more complex models that allow the link between the probability response and the fundamentals to vary over time and across countries. However, out-of-sample forecast evaluation using several loss functions and equal-predictive-ability tests suggests that simplicity beats complexity. Parsimonious pooled logit models produce the most accurate sovereign default forecasts and outperform the naive benchmarks.     

Transparent plasmonic nanocontainers protect organic fluorophores against photobleaching

Numerous research efforts are investigating the possibility of using light interactions with metallic nanoparticles to improve the fluorescence properties of nearby molecules. Few investigations have considered the encapsulation of molecules in metallic nanocavities. In this paper, we present the optical properties of new hybrid nanoparticles consisting of gold nanoshells and fluorescent organic dyes in their liquid cores. Microspectroscopy on single nanoparticle demonstrates that the extinction spectra are in good agreement with Mie's theory. Finite difference time domain (FDTD) calculations reveal that excitation and emission radiations are efficiently transmitted through the thin gold nanoshells. Thus, they can be considered as transparent plasmonic nanocontainers for photoactive cores. In agreement with FDTD calculations, measurements show that fluorophores encapsulated in gold nanoshells keep their brightness, but they show fluorescence lifetimes 1 order of magnitude shorter. As a salient consequence, the photoresistance of encapsulated organic dyes is also improved by an order of magnitude. This unusual ultraviolet photoresistance results from the reduced probability of triplet-singlet conversion that eventually exposes dyes to singlet oxygen photodegradation.     

Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence

The conserved family of fungal Ste20 p21-activated serine-threonine protein kinases regulate several signalling cascades. In Saccharomyces cerevisiae Ste20 is involved in pheromone signalling, invasive growth, the hypertonic stress response, cell wall integrity and binds Cdc42, a Rho-like small GTP-binding protein required for polarized morphogenesis. We have cloned the STE20 homologue from the fungal pathogen Candida glabrata and have shown that it is present in a single copy in the genome. Translation of the nucleotide sequence predicts that C. glabrata Ste20 contains a highly conserved p21-activated serine-threonine protein kinase domain, a binding site for G-protein beta subunits and a regulatory Rho-binding domain that enables the kinase to interact with Cdc42 and/or Rho-like small GTPases. C. glabrata Ste20 has 53% identity and 58% predicted amino acid similarity to S. cerevisiae Ste20 and can complement both the nitrogen starvation-induced filamentation and mating defects of S. cerevisiae ste20 mutants. Analysis of ste20 null and disrupted strains suggest that in C. glabrata Ste20 is required for a fully functional hypertonic stress response and intact cell wall integrity pathway. C. glabrata Ste20 is not required for nitrogen starvation-induced filamentation. Survival analysis revealed that C. glabrata ste20 mutants, while still able to cause disease, are mildly attenuated for virulence compared to reconstituted STE20 cells.