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排序方式: 共有511条查询结果,搜索用时 15 毫秒
41.
42.
Loredana Elena Nita Aurica P Chiriac Sossio Cimmino Clara Silvestre Donatella Duraccio Cornelia Vasile 《Polymer International》2008,57(2):342-349
BACKGROUND: The possibility to use β‐cyclodextrin as biodegradable tensioactive and an electromagnetic field in order to improve the kinetic parameters of radical emulsion polymerization is of interest. Thus, the influence of different surfactants—sodium lauryl sulfate (SLS) and β‐cyclodextrin (CD)—on the pathway of emulsion polymerization of methyl methacrylate (MMA) and emulsion copolymerization of MMA with 2,3‐epoxypropyl methacrylate (GMA) performed with or without the presence of a continuous electromagnetic field (MF) was studied. RESULTS: The presence of the MF leads to a considerable increase of the conversion during the first part of the reaction if the classic surfactant (SLS) is used. The reactions performed without MF and with CD exhibit a decrease of the conversion and of the polymerization rate as compared with the variants using SLS. The swelling rate and the maximum degree of swelling vary with the surfactant nature and with the reaction conditions and MF presence. Data from thermogravimetry and differential scanning calorimetry evidence the dependences between the polymer characteristics and the preparation conditions. CONCLUSION: This research underlines the coupling possibilities of the influence of a MF—growth of the reaction rate and conversion explained through radical pairs mechanism—with a combination of the ‘cage’ effect and ‘conformational control’ afforded by CD. The presence of MF and CD during the syntheses leads to an increase of Tg and an increase of PMMA and P(MMA‐co‐GMA) thermal stability. Copyright © 2007 Society of Chemical Industry 相似文献
43.
Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains 下载免费PDF全文
Dr. Bruno Tasso Dr. Federica Novelli Dr. Michele Tonelli Dr. Anna Barteselli Dr. Nicoletta Basilico Dr. Silvia Parapini Prof. Donatella Taramelli Prof. Anna Sparatore Prof. Fabio Sparatore 《ChemMedChem》2015,10(9):1570-1583
Chloroquine is commonly used in the treatment and prevention of malaria, but Plasmodium falciparum, the main species responsible for malaria‐related deaths, has developed resistance against this drug. Twenty‐seven novel chloroquine (CQ) analogues characterized by a side chain terminated with a bulky basic head group, i.e., octahydro‐2H‐quinolizine and 1,2,3,4,5,6‐hexahydro‐1,5‐methano‐8H‐pyrido[1,2‐a][1,5]diazocin‐8‐one, were synthesized and tested for activity against D‐10 (CQ‐susceptible) and W‐2 (CQ‐resistant) strains of P. falciparum. Most compounds were found to be active against both strains with nanomolar or sub‐micromolar IC50 values. Eleven compounds were found to be 2.7‐ to 13.4‐fold more potent than CQ against the W‐2 strain; among them, four cytisine derivatives appear to be of particular interest, as they combine high potency with low cytotoxicity against two human cell lines (HMEC‐1 and HepG2) along with easier synthetic accessibility. Replacement of the 4‐NH group with a sulfur bridge maintained antiplasmodial activity at a lower level, but produced an improvement in the resistance factor. These compounds warrant further investigation as potential drugs for use in the fight against malaria. 相似文献
44.
Marcéo A. Milani Michèle O. de SouzaRoberto F. de Souza 《Catalysis communications》2010,11(13):1094-1097
[Ni(Ph2PCHCOPh)(Ph)(PPh3)] (NiP^O) and Cp2ZrCl2/methylaluminoxane (MAO), well known as ethylene oligomerization and polymerization catalysts, respectively, are combined to produce LLDPE by in situ polymerization. Melting temperature (Tm), degree of crystallinity (χc), intrinsic viscosity, average molecular weight and 13C NMR analysis of copolymers confirm the insertion of α-olefins into the polyethylene chain. Variations in α-olefin concentration and ethylene pressure during the polymerization stage lead to changes in the degree of branching. The resulting copolymers have χc and Tm in the 25.8–65.2% and 114–132 °C ranges, respectively. Experimental results show the versatility of the dual-function catalyst. 相似文献
45.
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells 下载免费PDF全文
46.
Giuseppina Adiletta Loredana Liguori Donatella Albanese Paola Russo Marisa Di Matteo Alessio Crescitelli 《Food and Bioprocess Technology》2017,10(9):1631-1641
A preliminary characterization of two new soft-seeded pomegranate varieties (MR-100® and KINGDOM®) based on their main physico-chemical and nutritional parameters was reported. The two varieties showed significant differences (p ≤ 0.05) in polyphenols, anthocyanins and antioxidant activity. Kingdom pomegranate had higher polyphenols (2524.73 mg GAE/L), anthocyanins (752.49 mg C3gE/L) and antioxidant activity (EC50 13.58 μL/mL) than MR-100 (1792.74 mg GAE/L, 141.29 mg C3gE/L and EC50 47.53 μL/mL, respectively). Moreover, minimally processed arils of the two varieties were packaged in semipermeable and micro-perforated film at 5 °C, and the quality changes that occurred during storage condition (15 days) were investigated. During storage, Kingdom arils exhibited a better performance in terms of antioxidant activity, polyphenols and anthocyanin content with respect to MR-100. Furthermore, the packaging systems did not affect the estimated quality parameters for both varieties. Based on the sensory evaluation and microbial counts, both aril varieties reached, at 15-day storage, suitable values for commercial purpose. 相似文献
47.
A novel 3D homogenized FE limit analysis software is proposed for the fragility curve evaluation of entire existing masonry churches. The approach is a two-step one. In the first phase homogenized masonry strength domains are obtained using a simplified kinematic procedure applied on a three-leaf unitary cell. In the second phase, homogenized domains are implemented at a structural level on a plate and cell kinematic FE software. The procedure is tested on two real scale existing churches located in Italy and compared to results provided by means of a conventional elastic approach performed by means of a standard commercial software. The global behavior at failure and the overall strength of the buildings are assessed through Monte Carlo simulations varying both masonry mechanical properties and direction of the equivalent seismic load. 相似文献
48.
In this study, delamination of a perfectly-adherent FRP reinforcement from a masonry pillar is investigated by means of a fully three-dimensional finite element model. It is shown that the width of the FRP reinforcement governs the propagation of damage through the brick bulk starting from the anchorage of the strip, and influences significantly the overall response in terms of peak strength, ductility and fracture energy. The resulting failure mechanisms are specified. A critical comparison with formulae provided by Italian design code is also provided, for which mechanically-based improvements are suggested, taking into account three-dimensional effects. 相似文献
49.
R. Baldoni A. Fernández Anta K. Ioannidou A. Milani 《Theoretical computer science》2011,412(12-14):1066-1080
We present a model of a mobile ad-hoc network in which nodes can move arbitrarily on the plane with some bounded speed. We show that without any assumption on some topological stability, it is impossible to solve the geocast problem deterministically despite connectivity and no matter how slowly the nodes move. Moreover, even if each node maintains a stable connection with each of its neighbors for some period of time, it is impossible to solve the geocast problem if nodes move too fast. Additionally, we give a tradeoff lower bound which shows that the faster the nodes can move on a monodimensional space, the more costly it would be to solve the geocast problem. We provide geocasting algorithms for the case where nodes move in one dimension and also when they can move on the plane (i.e., in two dimensions). We prove correctness of our algorithms by giving exact bounds on the speed of movement. Our analysis helps understand the impact of speed of nodes, firstly, on geocasting solvability and, secondly, on the cost of geocasting. 相似文献
50.
Maria Mastrodonato Donatella Mentino Giuseppa Esterina Liquori Domenico Ferri 《Microscopy research and technique》2013,76(2):156-162
The mucins of colonic murine mucus are highly O‐glycosilated sulfosialoglycoproteins. We have characterized the sialylation pattern of oligosaccharide chains of colonic murine mucins by conventional histochemical methods and by lectin histochemistry combined with chemical pretreatments and sialidase digestion. Oligosaccharide chains are strongly sulphated, with an increase of sulfation from the proximal toward the distal colon and a decrease of sialic acid expression and acetylation toward the distal colon. In the goblet cells of proximal colon, sialic acid bound α2,3 to Galβ1,3GalNAc subterminal dimers is diacetylated at C7,C8;C7,C9;C8,C9 or triacetylated at C7,8,9. In the distal colon, sialic acid‐linked α2,3 to Galβ1,3GalNAc subterminal dimers shows reduced O‐acetylation at C7 and/or C8, while acetyl substituents at C9 and at C4 are almost absent. Sialic acid is involved in different essential physiological functions; thus, alterations of its expression and acetylation in oligosaccharide chains of intestinal mucins are generally associated with diseases, such as ulcerative colitis and cancer. Mice may represent a suitable animal model to study alterations of oligosaccharidic chains in colonic mucins and lectin histochemistry combined with chemical pretreatments, and enzyme digestion may be a valuable tool for this study. Our present work may represent a landmark for further lectin histochemical studies to evaluate alterations of mouse colon mucins under different physiological, pathological, or experimental conditions, with possible translational value in humans. Microsc. Res. Tech., 2013. © 2012 Wiley Periodicals, Inc. 相似文献