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991.
Van Quan TRAN Hai-Van Thi MAI Thuy-Anh NGUYEN Hai-Bang LY 《Frontiers of Structural and Civil Engineering》2022,16(7):928
The compressive strength of self-compacting concrete (SCC) needs to be determined during the construction design process. This paper shows that the compressive strength of SCC (CS of SCC) can be successfully predicted from mix design and curing age by a machine learning (ML) technique named the Extreme Gradient Boosting (XGB) algorithm, including non-hybrid and hybrid models. Nine ML techniques, such as Linear regression (LR), K-Nearest Neighbors (KNN), Support Vector Machine (SVM), Decision Trees (DTR), Random Forest (RF), Gradient Boosting (GB), and Artificial Neural Network using two training algorithms LBFGS and SGD (denoted as ANN_LBFGS and ANN_SGD), are also compared with the XGB model. Moreover, the hybrid models of eight ML techniques and Particle Swarm Optimization (PSO) are constructed to highlight the reliability and accuracy of SCC compressive strength prediction by the XGB_PSO hybrid model. The highest number of SCC samples available in the literature is collected for building the ML techniques. Compared with previously published works’ performance, the proposed XGB method, both hybrid and non-hybrid models, is the most reliable and robust of the examined techniques, and is more accurate than existing ML methods (R2 = 0.9644, RMSE = 4.7801, and MAE = 3.4832). Therefore, the XGB model can be used as a practical tool for engineers in predicting the CS of SCC. 相似文献
992.
G. Tran Van D. Carron P. Le Masson V. Robin A. Andrieu J. Stodolna 《Journal of Materials Engineering and Performance》2018,27(10):5114-5123
Liquation cracking may occur in the heat-affected zone during welding. Two factors influence this phenomenon: the tensile stresses generated during welding and the potential loss of ductility due to the presence of a liquid film at grain boundaries depending on their chemical composition. Gleeble hot ductility tests have been used to study the combined effect of boron content and holding time on ductility drop in the liquation temperature range of a 316L type austenitic stainless steel. It is shown that high boron contents and short holding times promote the loss of ductility in this temperature range. Secondary ion mass spectrometry has been used to correlate mechanical results to boron distribution either at grain boundaries or in the bulk. Other welding tests have been performed to confirm the influence of boron content on hot cracking sensitivity of AISI 316L stainless steels. Results indicate that cracks appear on all specimens but at different strain levels. The higher the boron content is, the more the specimen exhibits tendency to hot cracking. 相似文献
993.
Emily L. Seet Jennifer K. Yee Juanita K. Jellyman Guang Han Michael G. Ross Mina Desai 《Lipids》2015,50(6):565-573
In offspring exposed in utero to a maternal diet high in fat (HF), we have previously demonstrated that despite similar birth weights, HF adult offspring at 6 months of age had significantly higher body weights, greater adiposity, and increased triacylglycerol (TAG) levels as compared to controls. We hypothesized that a maternal HF diet predisposes to offspring adiposity via a programmed increase in the synthesis of monounsaturated fatty acids in the liver and hence increased substrate availability for liver TAG synthesis. We further hypothesized that programmed changes in offspring liver fatty acid metabolism are associated with increased liver expression of the lipogenic enzyme stearoyl‐CoA desaturase‐1 (SCD‐1). Female rats were maintained on a HF diet rich in monounsaturated fatty acids (MUFA) prior to and throughout pregnancy and lactation. After birth, newborns were nursed by the same dam, and all offspring were weaned to control diet. Plasma and liver fatty acid compositions were determined using gas chromatography/mass spectrometry. Fatty acid C16 desaturation indices of palmitoleic/palmitic and (vaccenic + palmitoleic)/palmitic and the C18 desaturation index of oleic/stearic were calculated. Liver protein abundance of SCD‐1 was analyzed in newborns and adult offspring. Plasma and liver C16 desaturation indices were decreased in HF newborns, but increased in the adult offspring. Liver SCD‐1 expression was increased in the HF adult offspring. These data show that the maternal HF diet during pregnancy and lactation increases offspring liver SCD‐1 protein abundance and alters the liver C16 desaturase pathway. 相似文献
994.
Discovery of Quinoline‐Derived Trifluoromethyl Alcohols,Determination of Their in vivo Toxicity and Anticancer Activity in a Zebrafish Embryo Model 下载免费PDF全文
Prof. Dr. Vinoth Sittaramane Jihan Padgett Philip Salter Ashley Williams Shauntelle Luke Rebecca McCall Prof. Dr. Jonathan F. Arambula Vincent B. Graves Mark Blocker David Van Leuven Keturah Bowe Julia Heimberger Hannah C. Cade Supriya Immaneni Prof. Dr. Abid Shaikh 《ChemMedChem》2015,10(11):1802-1807
In this study the rational design, synthesis, and anticancer activity of quinoline‐derived trifluoromethyl alcohols were evaluated. Members of this novel class of trifluoromethyl alcohols were identified as potent growth inhibitors in a zebrafish embryo model. Synthesis of these compounds was carried out with an sp3‐C?H functionalization strategy of methyl quinolines with trifluoromethyl ketones. A zebrafish embryo model was also used to explore the toxicity of ethyl 4,4,4‐trifluoro‐3‐hydroxy‐3‐(quinolin‐2‐ylmethyl)butanoate ( 1 ), 2‐benzyl‐1,1,1‐trifluoro‐3‐(quinolin‐2‐yl)propan‐2‐ol ( 2 ), and trifluoro‐3‐(isoquinolin‐1‐yl)‐2‐(thiophen‐2‐yl)propan‐2‐ol ( 3 ). Compounds 2 and 3 were found to be more toxic than compound 1 ; apoptotic staining assays indicated that compound 3 causes increased cell death. In vitro cell proliferation assays showed that compound 2 , with an LC50 value of 14.14 μm , has more potent anticancer activity than cisplatin. This novel class of inhibitors provides a new direction in the discovery of effective anticancer agents. 相似文献
995.
Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans 下载免费PDF全文
Ilandari Dewage Udara Anulal Premachandra Kevin A. Scott Chengtian Shen Dr. Fuqiang Wang Shelley Lane Prof. Dr. Haoping Liu Prof. Dr. David L. Van Vranken 《ChemMedChem》2015,10(10):1672-1686
A spiroindolinone, (1S,3R,3aR,6aS)‐1‐benzyl‐6′‐chloro‐5‐(4‐fluorophenyl)‐7′‐methylspiro[1,2,3a,6a‐tetrahydropyrrolo[3,4‐c]pyrrole‐3,3′‐1H‐indole]‐2′,4,6‐trione, was previously reported to enhance the antifungal effect of fluconazole against Candida albicans. A diastereomer of this compound was synthesized, along with various analogues. Many of the compounds were shown to enhance the antifungal effect of fluconazole against C. albicans, some with exquisite potency. One spirocyclic piperazine derivative, which we have named synazo‐1, was found to enhance the effect of fluconazole with an EC50 value of 300 pM against a susceptible strain of C. albicans and going as low as 2 nM against some resistant strains. Synazo‐1 exhibits true synergy with fluconazole, with an FIC index below 0.5 in the strains tested. Synazo‐1 exhibited low toxicity in mammalian cells relative to the concentrations required for antifungal synergy. 相似文献
996.
Mazzetto A. M. Barneze A. S. Feigl B. J. Van Groenigen J. W. Oenema O. De Klein C. A. M. Cerri C. C. 《Nutrient Cycling in Agroecosystems》2015,101(1):83-92
Nutrient Cycling in Agroecosystems - Animal production systems are important sources of greenhouse gases (GHGs), especially methane (CH4) and nitrous oxide (N2O). GHG emissions from urine patches... 相似文献
997.
998.
Within the last decade, metal‐free heteroatom doped carbon nanomaterials have gained attention as effective electrocatalysts for the oxygen reduction reaction (ORR) in many electrochemical systems. Since then, reports have stated that the ORR catalytic activity, onset potential, and H2O production selectivity of these materials is similar to that of platinum‐based catalysts. These statements rely on cyclic voltammetry (CV) and rotating disc electrode (RDE) measurements in liquid alkaline electrolyte. However, fuel cell researchers aim to replace the costly platinum catalysts in the more prominent acidic solid electrolyte proton exchange fuel cell (PEFC). In this respect, there are only a few reports of unpromising activity, stability, and H2O production selectivity. In addition, only few reports have been presented on the implementation of such materials in cathode catalyst layers of actual PEFC devices. This mini‐review aims to summarize and evaluate results of these reports. Material synthesis, cell power, open circuit voltage, stability properties, and proposed active sites are reviewed. To date, the highest reported PEFC power densities with guaranteed metal‐free heteroatom doped carbon cathode catalysts have reached up to 321 mW cm−2; which although a promising value is substantially short of values obtained for platinum based catalysts. 相似文献
999.
1000.
J. Bonilla M. Diehl F. Logist B. De Moor J. Van Impe 《Computers & Chemical Engineering》2010,34(6):953-964
This paper proposes an initialization approach for parameter estimation problems (PEPs) involving parameter-affine dynamic models. By using the state measurements, the nonconvex PEP is modified such that a convex approximation to the original PEP is obtained. The modified problem is solved by convex optimization methods yielding an approximate solution to the original PEP. The approximate solution can be further refined by linearizing the original problem around the obtained minimum. An assessment of the distance between the real solution and the one provided by the linearization of the problem around the convex approximation is presented. The optimum obtained by the convex approximation is used to subsequently initialize a simultaneous Gauss–Newton (SGN) approach on the original nonconvex PEP. Comparative results for the SGN with arbitrary initialization and with the proposed approach are presented using three benchmark examples in the chemical and biological fields. 相似文献