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91.
Chatterjee Gaurav Latorre Laurent Mailly Frédérick Nouet Pascal Hachelef Nacim Oudea Coumar 《Microsystem Technologies》2017,23(9):3969-3978
Microsystem Technologies - Inertial measurement units (IMU) are essentially a combination of acceleration and rotation rate sensors, generating position and attitude information. For tactical and... 相似文献
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Hallal Nassim Yelles Chaouche Abdelkrim Hamai Lamine Lamali Atmane Dubois Laurent Mohammedi Yahia Hamidatou Mouloud Djadia Leila Abtout Abdeslam 《Bulletin of Engineering Geology and the Environment》2019,78(8):5653-5670
Bulletin of Engineering Geology and the Environment - A better understanding of the spatiotemporal evolution of landslides in urban zones is a key factor in assessing the risk of future slides... 相似文献
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Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single‐Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands 下载免费PDF全文
Joël Mercier Laurence Archen Véronique Bollu Stéphane Carré Yves Evrard Dr. Eric Jnoff Dr. Benoît Kenda Bénédicte Lallemand Dr. Philippe Michel Dr. Florian Montel Dr. Florence Moureau Nathalie Price Dr. Yannick Quesnel Dr. Xavier Sauvage Dr. Anne Valade Dr. Laurent Provins 《ChemMedChem》2014,9(4):693-698
The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non‐acetamide lead compounds, UCB‐A, UCB‐H and UCB‐J, the first single‐digit nanomolar SV2A ligands with suitable properties for development as PET tracers. 相似文献
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Zeeshan Hafeez Céline Cakir-Kiefer Xavier Lecomte Laurent Miclo Annie Dary-Mourot 《Journal of dairy science》2019,102(1):113-123
This study addresses the hypothesis that the extracellular cell-associated X-prolyl dipeptidyl-peptidase activity initially described in Streptococcus thermophilus could be attributable to the intracellular X-prolyl dipeptidyl-peptidase PepX. For this purpose, a PepX-negative mutant of S. thermophilus LMD-9 was constructed by interrupting the pepX gene and named LMD-9-ΔpepX. When cultivated, the S. thermophilus LMD-9 wild type strain grew more rapidly than its ΔpepX mutant counterpart. Thus, the growth rate of the LMD-9-ΔpepX strain was reduced by a factor of 1.5 and 1.6 in milk and LM17 medium (M17 medium supplemented with 2% lactose), respectively. The negative effect of the PepX inactivation on the hydrolysis of β-casomorphin-7 was also observed. Indeed, when incubated with this peptide, the LMD-9-ΔpepX mutant cells were unable to hydrolyze it, whereas this peptide was completely degraded by the S. thermophilus LMD-9 wild type cells. This hydrolysis was not due to leakage of intracellular PepX, as no peptide hydrolysis was highlighted in cell-free filtrate of wild type strain. Therefore, based on these results, it can be presumed that though lacking an export signal, the intracellular PepX might have accessed the β-casomorphin-7 externally, perhaps via its galactose-binding domain-like fold, this domain being known to help enzymes bind to several proteins and substrates. Therefore, the identification of novel distinctive features of the proteolytic system of S. thermophilus will further enhance its credibility as a starter in milk fermentation. 相似文献
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International Journal of Fracture - 相似文献
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