Morphology,crystallization and melting behaviour of films of isotactic polypropylene blended with ethylene-propylene copolymers and polyisobutylene

The crystallization, the morphology and the thermal behaviour of thin films of isotactic polypropylene (iPP) blended with elastomers such as random ethylene-propylene copolymers (EPM) with different ethylene content and polyisobutylene (PiB) were investigated by means of optical microscopy, differential scanning calorimetry and wide angle X-ray diffractometry. During crystallization EPM copolymers are ejected on the surface of the film forming droplet-like domains. A different morphology is observed in iPP/PiB blends. For these mixtures the elastomers separate from the iPP phase forming spherical domains that are incorporated in the iPP intraspherulitic regions. Both EPM and PiB elastomers act as nucleant agents for iPP spherulites. This nucleation efficiency is strongly dependent on the chemical structure and molecular mass of the elastomers. The addition of EPM causes an elevation of the observed and equilibrium melting temperature of iPP. This unusual effect may be accounted for by assuming that the elastomers are able to extract selectively the more defective molecules of iPP. The depression of the growth rate of spherulites and the observed and equilibrium melting temperature of iPP, noted in iPP/PiB blends, suggests that these two polymers have a certain degree of compatibility in the melt.     

Towards children's creative museum engagement and collaborative sense-making

Abstract

In this article, we elucidate a socio-culturally framed approach to supporting children's creative museum engagement. Specifically, we focus on social activities and socio-cultural resources that can act as boundary-permeating objects in mediating children's creative engagement and collaborative sense-making regarding cultural content within, across and beyond the spatio-material context of the museum. We contend that designing and organising children's creative engagement and collaborative sense-making in ways that cultivate boundary-crossing broadens opportunities for engagement and leverages children's creative potential and expansive learning. We build our argument by starting with a theoretical introduction to the design principles that constitute the Kids, Museums, and Technology Programme. We will illuminate the design principles of the programme with empirical examples and consider how the design principles and their situated construction can help us re-imagine museum exhibitions as hybrid, boundary-permeating spaces that afford novel transformative interactions, as well as new roles and identities for both children and museums.     

HCI and Society: Towards a Typology of Universal Design Principles

The task of this article is to focus on aspects of design from a theoretical perspective that works out a general framework of techno-social design that is grounded in the notion of the participatory, cooperative, sustainable information society. The approach is normative in that it is based on the judgment that not just any information society is needed, but one that has specific qualities that this article tries to identify. Methodologically, the article works out a conceptual framework that synthesizes general social theory and human–computer interaction. Design is seen as a social process that shapes society and techno-social systems. First, a model of society that is based on the dialectical interaction of economic, political, and cultural subsystems is introduced. Then, the notion of the the participatory, cooperative, sustainable information society is introduced. This theoretical definition is then used for classifying design principles of techno-social information systems from a social theory perspective.     

On semidefinite programming bounds for graph bandwidth

In this paper, we propose two new lower bounds on graph bandwidth and cyclic bandwidth based on semidefinite programming (SDP) relaxations of the quadratic assignment problem. We compare the new bounds with two other SDP bounds reported in [A. Blum, G. Konjevod, R. Ravi, and S. Vempala, Semi-definite relaxations for minimum bandwidth and other vertex-ordering problems, Theoret. Comput. Sci. 235(1) (2000), pp. 25–42; J. Povh and F. Rendl, A copositive programming approach to graph partitioning, SIAM J. Optim. 18(1) (2007), pp. 223–241].     

Visual Quantitative Detection of Circulating Tumor Cells with Single‐Cell Sensitivity Using a Portable Microfluidic Device

Immunocytological technologies, molecular technologies, and functional assays are widely used for detecting circulating tumor cells (CTCs) after enrichment from patients' blood sample. Unfortunately, accessibility to these technologies is limited due to the need for sophisticated instrumentation and skilled operators. Portable microfluidic devices have become attractive tools for expanding the access and efficiency of detection beyond hospitals to sites near the patient. Herein, a volumetric bar chart chip (V‐Chip) is developed as a portable platform for CTC detection. The target CTCs are labeled with aptamer‐conjugated nanoparticles (ACNPs) and analyzed by V‐Chip through quantifying the byproduct (oxygen) of the catalytic reaction between ACNPs and hydrogen peroxide, which results in the movement of an ink bar to a concentration‐dependent distance for visual quantitative readout. Thus, the CTC number is decoded into visually quantifiable information and a linear correlation can be found between the distance moved by the ink and number of cells in the sample. This method is sensitive enough that a single cell can be detected. Furthermore, the clinical capabilities of this system are demonstrated for quantitative CTC detection in the presence of a high leukocyte background. This portable detection method shows great potential for quantification of rare cells with single‐cell sensitivity for various applications.     

Network Analysis of Gut Microbiome and Metabolome to Discover Microbiota-Linked Biomarkers in Patients Affected by Non-Small Cell Lung Cancer

Several studies in recent times have linked gut microbiome (GM) diversity to the pathogenesis of cancer and its role in disease progression through immune response, inflammation and metabolism modulation. This study focused on the use of network analysis and weighted gene co-expression network analysis (WGCNA) to identify the biological interaction between the gut ecosystem and its metabolites that could impact the immunotherapy response in non-small cell lung cancer (NSCLC) patients undergoing second-line treatment with anti-PD1. Metabolomic data were merged with operational taxonomic units (OTUs) from 16S RNA-targeted metagenomics and classified by chemometric models. The traits considered for the analyses were: (i) condition: disease or control (CTRLs), and (ii) treatment: responder (R) or non-responder (NR). Network analysis indicated that indole and its derivatives, aldehydes and alcohols could play a signaling role in GM functionality. WGCNA generated, instead, strong correlations between short-chain fatty acids (SCFAs) and a healthy GM. Furthermore, commensal bacteria such as Akkermansia muciniphila, Rikenellaceae, Bacteroides, Peptostreptococcaceae, Mogibacteriaceae and Clostridiaceae were found to be more abundant in CTRLs than in NSCLC patients. Our preliminary study demonstrates that the discovery of microbiota-linked biomarkers could provide an indication on the road towards personalized management of NSCLC patients.     

Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P

Background: Pathogenetic mechanisms involved in the progression of non-alcoholic fatty liver disease (NAFLD) are complex and multifactorial. We investigated oxidative stress through the measurement of selenoprotein P (SeP) in serum and we explored its relation to metabolic derangements and liver damage in a group of non-diabetic NAFLD subjects. Methods: 57 NAFLD patients underwent a double-tracer oral glucose tolerance test (OGTT). Insulin resistance (IR) components were calculated at baseline as follows: hepatic-IR = (endogenous glucose production*insulin); peripheral-IR = (glucose rate of disappearance(Rd)); adipose-tissue(AT)-IR as Lipo-IR = (glycerol rate of appearance (Ra)*insulin) or AT-IR = (free fatty acids (FFAs)*insulin). The lipid and amino acid (AA) profiles were assessed by gas chromatography–mass spectrometry. SeP levels were measured by enzyme immunosorbent assay. Results: Circulating SeP correlated with insulin (r_S = 0.28), FFAs (r_S = 0.42), glucose Rd (r_S = −0.33) and glycerol Ra (r_S = −0.34); consistently, SeP levels correlated with Lipo-IR and AT-IR (r_S > 0.4). Among the AA and lipid profiles, SeP inversely correlated with serine (r_S = −0.31), glycine (r_S = −0.44) and branched chain AA (r_S = −0.32), and directly correlated with saturated (r_S = 0.41) and monounsaturated FFAs (r_S = 0.40). Hepatic steatosis and fibrosis increased in subjects with higher levels of SeP. In multivariable regression analysis, SeP was associated with the degree of hepatic fibrosis (t = 2.4, p = 0.022). Conclusions: SeP levels were associated with an altered metabolic profile and to the degree of hepatic fibrosis, suggesting a role in the pathogenesis of NAFLD.     

Causes and subjective evaluation of blurriness in video frames

A method to automatically assess the seriousness of the blurriness artifact in video frames displayed on a state-of-the-art TV monitor is presented. Different types of the artifact are identified, depending on the stage of the video chain where they are originated, namely, blur produced during acquisition, post-processing and encoding. Every type is observed to produce slightly different effects on the frame and, more importantly, to affect image quality differently, so that distinguishing among types is necessary to perform an appropriate restoration. Two main metrics are therefore introduced for classifying the type of blurriness and, when useful, measuring its strength. Particular care was taken in distinguishing the intentional background blur, which does not cause an actual degradation in the frame quality. The appropriateness of the method in classifying the artifact and predicting the subjective frame quality was verified in the experiments.