Dexamethasone-induced cytotoxic activity and drug resistance effects in androgen-independent prostate tumor PC-3 cells are mediated by lipocortin 1

We studied the seated buttock pressure distribution in six paraplegic patients by means of computerized pressure mapping. They were all male and their age ranged from 18 to 48 years old. Their level of paralysis varied from Th5 to L1. Five kinds of wheelchair cushions were studied: an air cushion, a contour cushion, a polyurethane foam cushion, a Cubicushion (which is made of polyurethane foams) and a silicone gel cushion. A tactile sensor consisting of 2064 matrices was used for measuring the buttock pressure distribution and the data was analyzed on a personal computer. Peak pressures measured for each cushion were as follows (in descending order): the Cubicushion, the polyurethane foam cushion, the contour cushion, the silicone gel cushion, and the air cushion. The areas of total contact measured for each cushion were as follows (in descending order): the air cushion, the silicone gel cushion, the polyurethane foam cushion, the contour cushion and the Cubicushion. Based on these findings, we conclude that the most advantageous cushion is the air cushion or the silicone gel cushion. Likewise, we conclude that the Cubicushion is not practical for pressure sore prevention.     

L x-ray satellite energies

Theoretical energies are tabulated for the L x-ray satellites that arise from electric dipole and quadrupole transitions in the presence of one spectator hole in the M- or N-shell. Results are listed for 11 elements with atomic numbers 65 ≤ Z ≤ 95. The computations are relativistic and include quantum-electrodynamic corrections. Subsidiary tables list the Coulomb and Breit interaction energies for double-hole states and the relative x-ray intensities of double-hole multiplet states.     

In situ synthesised TiO2 ‐chitosan‐chondroitin 4–sulphate nanocomposites for bone implant applications

The artificial materials for bone implant applications are gaining more importance in the recent years. The series titania‐chitosan‐chondroitin 4–sulphate nanocomposites of three different concentrations (2:1:x, where x ‐ 0.125, 0.25, 0.5) have been synthesised by in situ sol–gel method and characterised by various techniques. The particle size of the nanocomposites ranges from 30–50 nm. The bioactivity, swelling nature, and the antimicrobial nature of the nanocomposites were investigated. The swelling ability and bioactivity of the composites is significantly greater and they possess high zone of inhibition against the microorganisms such as Staphylococcus aureus and Escherichia coli. The cell viability of the nanocomposites were evaluated by using MG‐63 and observed the composites possess high cell viability at low concentration. The excellent bioactivity and biocompatibility makes these nanocomposites a promising biomaterial for bone implant applications.Inspec keywords: titanium compounds, filled polymers, nanocomposites, bone, orthopaedics, biomedical materials, sol‐gel processing, nanofabrication, particle size, swelling, microorganisms, cellular biophysics, nanomedicine, prostheticsOther keywords: in situ synthesised TiO₂ ‐chitosan‐chondroitin 4‐sulphate nanocomposites, bone implant applications, artificial materials, in situ sol‐gel method, particle size, swelling nature, antimicrobial nature, microorganisms, Staphylococcus aureus, Escherichia coli, cell viability, MG‐63, biomaterial, size 30 nm to 50 nm, TiO₂      

Fracture toughness of the interface between Ni–Cr/ceramic,alumina/ceramic and zirconia/ceramic systems

Few studies have focused on the interface fracture performance of bi‐layered structures, which have an important role in dental restorations, using ceramic materials. The purpose of this study is to evaluate the fracture mechanics performance of the Ni–Cr/ceramic, alumina/ceramic and zirconia/ceramic interfaces by investigating the propagation of an interfacial crack under a wide range of mode mixities. The effect of the mechanical properties of the base materials and the interface, on the crack initiation and crack path, will also be studied. The finite element method (FEM) was used to calibrate the production of the experimental specimens, allowing to obtain the minimum dimensions and amounts of material needed to correctly characterize the fracture event. The specimens were tested until failure using a three‐point bending test machine. The interface fracture parameters were obtained using the FEM. For all specimens, the cracks propagated into the ceramic. The results suggest that, in Ni–Cr/ceramic, alumina/ceramic and zirconia/ceramic bi‐layered structures, the ceramic is weaker than the interface, which can be used to explain the clinical phenomenon that the ceramic chipping rate is larger than interface delamination rate. Consequently, a ceramic material with a larger fracture toughness is needed to decrease the failure rate of ceramic restorations.     

Detection of temporary flooded areas with potential floodwater mosquito production using imaging radar

Temporarily flooded areas can produce enormous numbers of floodwater mosquitoes, causing tremendous nuisance to people living in the vicinity. The aim of this study is to develop a remote-sensing method for detecting temporary flooded areas that can produce floodwater mosquitoes. For this objective, synthetic aperture radar (SAR) imagery from the European Remote Sensing satellite (ERS-2) and the Environmental Satellite (Envisat) are chosen. The images cover both flooded and dry periods around Lake Färnebofjärden, located in the lowlands of the River Dalälven, central Sweden, during the vegetation season between 2000 and 2006. Unsupervised classification and principal component analysis (PCA) are tested as methods for detecting floodwater mosquito production sites. In the unsupervised classification experiment, four types of images are tested. The classification of a synthetic colour image gives the best result with an overall accuracy of 85.7% and a kappa value of 0.7, as well as a 46% detection rate of field-mapped flooded areas. PCA is performed on a data set of 16 time series radar images. The resulting principal component (PC) bands provide information about flooding probability as well as vegetation structures. Regular flooding increases the probability for an area to provide breeding sites for floodwater mosquitoes. Thus, this approach will be very useful in estimating the risk of floodwater mosquito establishment.     

Extensible Prototyping for pragmatic engineering of knowledge-based systems

Knowledge-based systems (KBSs) have been built and practically applied in various contexts for decades. Yet, they still challenge developers by their complexity: Apart from a sound knowledge base they likewise require comprehensive user interface (UI) and interaction design for supporting the task at hand optimally. However, current KBS-Engineering methodologies still mostly focus on knowledge base development, regarding UI/interaction design a more incidental, low priority task. Thus, the UI often is developed in a rather ad hoc manner, thereby neglecting the potential of experimental design and creating reusable solutions. The integration of (rapid) evolutionary prototyping activities with KBS Engineering offers the chance for incorporating UI/interaction design more prominently into the process while at the same time leveraging the overall development task; specifically, we propose Extensible Prototyping as a tailored prototyping approach and we suggest its integration with the Agile Process Model for knowledge-based systems in this paper. For practical support, we further introduce the customized prototyping and knowledge systems engineering tool ProKEt, and we report on practical experiences with applying both the approach and the tool.     

Summoning earth and fire: The energy development implications of Grameen Shakti (GS) in Bangladesh

Since its establishment in 1996, the nonprofit company Grameen Shakti (GS) has installed almost half a million solar home systems (SHS), 132,000 cookstoves, and 13,300 biogas plants among 3.1 million beneficiaries. They plan to ramp up their expansion so that by 2015, more than 1.5 million SHS are in place along with 100,000 biogas units and 5 million improved cookstoves. This article describes GS’s current activities, the contours of its programs, and likely reasons for its success. It also explores the remaining challenges facing GS and distils common lessons for other energy development assistance projects and programs around the world. After detailing research methods consisting primarily of research interviews and site visits, the article briefly explores the history of GS and summarizes its three most prominent programs. The article then identifies six distinct benefits to their programs—expansion of energy access, less deforestation and fewer greenhouse gas emissions, price savings, direct employment and income generation, improved public health, and better technology—before discussing challenges related to staff retention and organizational growth, living standards, technical obstacles, affordability, tension with other energy programs, political constraints, and awareness and cultural values.     

Biodegradable polymers applied in tissue engineering research: a review

Typical applications and research areas of polymeric biomaterials include tissue replacement, tissue augmentation, tissue support, and drug delivery. In many cases the body needs only the temporary presence of a device/biomaterial, in which instance biodegradable and certain partially biodegradable polymeric materials are better alternatives than biostable ones. Recent treatment concepts based on scaffold‐based tissue engineering principles differ from standard tissue replacement and drug therapies as the engineered tissue aims not only to repair but also regenerate the target tissue. Cells have been cultured outside the body for many years; however, it has only recently become possible for scientists and engineers to grow complex three‐dimensional tissue grafts to meet clinical needs. New generations of scaffolds based on synthetic and natural polymers are being developed and evaluated at a rapid pace, aimed at mimicking the structural characteristics of natural extracellular matrix. This review focuses on scaffolds made of more recently developed synthetic polymers for tissue engineering applications. Currently, the design and fabrication of biodegradable synthetic scaffolds is driven by four material categories: (i) common clinically established polymers, including polyglycolide, polylactides, polycaprolactone; (ii) novel di‐ and tri‐block polymers; (iii) newly synthesized or studied polymeric biomaterials, such as polyorthoester, polyanhydrides, polyhydroxyalkanoate, polypyrroles, poly(ether ester amide)s, elastic shape‐memory polymers; and (iv) biomimetic materials, supramolecular polymers formed by self‐assembly, and matrices presenting distinctive or a variety of biochemical cues. This paper aims to review the latest developments from a scaffold material perspective, mainly pertaining to categories (ii) and (iii) listed above. Copyright © 2006 Society of Chemical Industry