7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder in which loss of dopaminergic (DA) neurons (>50%) in the substantia nigra (SN) precedes most of the overt motor symptoms, making early diagnosis and treatment interventions difficult. Because PD has been associated with free radicals generated by nitric oxide, this study tested whether treatments of 7-nitroindazole (7NI), a nitric-oxide-synthase inhibitor, could reduce cognitive deficits that often emerge before overt motor symptoms in a presymptomatic rat model of PD. Rats were given intraperitoneal injections of 50 mg/kg 7NI (or vehicle) just before receiving bilateral, intrastriatal injections of the DA-toxin, 6-hydroxydopamine (6-OHDA). The rats were then given a battery of motor tasks, and their learning ability was assessed using a spatial reversal task in a water-T maze. Results indicate that 7NI treatments attenuate 6-OHDA-induced spatial learning deficits and protect against DA cell loss in the SN, suggesting that 7NI may have potential as an early, presymptomatic pharmacotherapy for PD. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychosocial predictors of supervisor-, peer-, subordinate-, and service-provider-targeted aggression.

The authors investigate whether known person predictors (trait anger, trait aggression) and situational predictors (perceived interpersonal mistreatment, perceived organizational sanctions against aggression) of supervisor-targeted aggression also predict employee's aggression toward other workplace targets, namely peers, subordinates, and customers' aggression toward service providers. The authors also investigate the moderating impact of situational factors on the relationship between person factors and aggression. Participants (N = 308) were asked whether they had a conflict with their supervisor, a subordinate, a work peer, and/or a service provider in the past 6 months. Different patterns of main and interaction effects emerged across the 4 targets, suggesting the importance of accounting for the target of aggression in workplace aggression research. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The impact of cross-training on team effectiveness.

The authors examined the role of cross-training in developing shared team-interaction mental models, coordination, and performance in a 2-experiment study using computer simulation methodology (for Experiment 1, N=45 teams; for Experiment 2, N=49 teams). Similar findings emerged across the 2 experiments. First, cross-training enhanced the development of shared team-interaction models. Second, coordination mediated the relationship between shared mental models and team performance. However, there was some inconsistency in the findings concerning the depth of cross-training necessary for improving shared mental models. Results are discussed in terms of the impact of different levels of cross-training on team effectiveness. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Role of peripheral vision in the directional control of rapid aiming movements.

This study addresses the question of whether peripheral vision is involved in the control of hand trajectory direction during an aiming task performed at high speed. Ten adult subjects were required to aim at targets in various positions by making a punching movement with their hand. The experimental conditions were varied so that different parts of hand trajectory could be seen in the peripheral field. Two movement times were applied:     

Remote Area Indigenous Housing: Towards a Model of Best Practice

This article analyses housing provision for Indigenous populations in remote communities, focusing particularly on the Indigenous Australian population. It uses a 'best practice' framework to do this. It then develops a model of best practice which is used to evaluate remote area Indigenous housing in terms of four stages and six components of housing provision. After summarising the results of the application of the model to some 26 examples, with more detailed analysis of two of them, it reaches conclusions about elements of best practice in remote area Indigenous housing, about best practice methodology and about the wider applicability of the model.     

Melodrama and film noir on today's big screen: How modern audiences experience yesterday's classics.

In the 1940s and 50s, melodrama was described as "the lady's film," whereas men were the supposed fans of film noir. No empirical studies were conducted with filmgoers of that era to validate such claims. This study examined responses of modern-day audiences comprising 16 females and 16 males to these classic genres. An experimental montage technique was developed to compare problem and solution scenes excerpted from 4 melodrama and 4 film noir movies. Participants rated each scene on fifteen 5-point scales related to cognitive and emotional responses and interpreted the meaning of each scene open-endedly. Quantitative analyses indicated that subjects were more sensitive to the character's emotions in melodrama, found this genre to be more complex, and were more apt to experience personal memories. Qualitative analyses revealed that subjects were more aware of the character's emotions and were more likely to identify with the character in melodramas. Interactions showed that participants judged the solution scenes in film noirs to be unrealistic and criticized the main character's actions. Male and female participants did not differentially respond to the two genres. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Laboratory study of impacts of concrete fragment sizes on wetland water chemistry

This study investigated the effects of urban concrete materials, of different particle sizes, immersed in water through a laboratory-based experiment. Water was sourced from a high conservation-value wetland (Blue Mountains upland swamp). Prior to the experiment, wetland water was dilute (32.5 μS/cm), acidic (pH 5.3) and had detectable major ion concentrations of only sodium and chloride. Water was exposed to three treatments of different concrete fragment sizes (whole, crushed and fine). All treatments increased conductivity and pH and also resulted in modified ionic composition where calcium, potassium, hydroxide, carbonate and sulphate were recorded at much high levels. The extent and speed of water chemistry changes was linked to the particle size of the concrete. The results of this study support the hypothesis that concrete can be an environmentally hazardous material influencing water quality in urban catchments.     

Spectral properties and dynamics of gold nanorods revealed by EMCCD‐based spectral phasor method

Gold nanorods (NRs) with tunable plasmon‐resonant absorption in the near‐infrared region have considerable advantages over organic fluorophores as imaging agents due to their brightness and lack of photobleaching. However, the luminescence spectral properties of NRs have not been fully characterized at the single particle level due to lack of proper analytic tools. Here, we present a spectral phasor analysis method that allows investigations of NRs' spectra at single particle level showing the spectral variance and providing spatial information during imaging. The broad phasor distribution obtained by the spectral phasor analysis indicates that spectra of NRs are different from particle to particle. NRs with different spectra can be identified in images with high spectral resolution. The spectral behaviors of NRs under different imaging conditions, for example, different excitation powers and wavelengths, were revealed by our laser‐scanning multiphoton microscope using a high‐resolution spectrograph with imaging capability. Our results prove that the spectral phasor method is an easy and efficient tool in hyper‐spectral imaging analysis to unravel subtle changes of the emission spectrum. We applied this method to study the spectral dynamics of NRs during direct optical trapping and by optothermal trapping. Interestingly, different spectral shifts were observed in both trapping phenomena. Microsc. Res. Tech. 78:283–293, 2015. © 2015 Wiley Periodicals, Inc.