A flexible array synthesis method using quadratic programming

A highly flexible synthesis method for an arbitrary array is proposed to best approximate a desired array pattern in a minimum-mean-square-error sense. The basic idea of the technique is to form a quadratic program with its cost function given by the mean-square error between the array response and a properly selected pattern described by a known mathematical function. This quadratic program can be a constrained or unconstrained optimization problem depending on the requirements of the desired array pattern. In formulating the quadratic program, no assumption has been made on the gain/phase response or characteristics of the individual array elements. Therefore, one can synthesize an array of arbitrary shape to any appropriate pattern with the characteristic of the array elements taken into consideration as long as one is able to model the array accurately. The proposed method is used to synthesize arrays of different shapes, linear as well as planar arrays (including rectangular and circular planar arrays), using a Chebyshev polynomial or zero function as a design template, to illustrate the feasibility of the proposed method     

Phosphatidylinositol 4,5-bisphosphate phospholipase C activity in particulate preparations from rat brain

We describe the hydrolysis of phosphatidylinositol 4,5-bisphosphate by a particulate rat brain preparation in the presence of the cationic detergent, cetrimide. The optimum cetrimide concentration was in the range 0.2–0.4 mg/ml; at higher or lower concentrations, the reaction rate diminished abruptly, suggesting that the electrical charge density of the micelle is critical for enzymatic attack. In other respects, such as its partial requirement for Ca⁺⁺ and its pH optimum of about 7.0, the particulate enzyme seems similar to soluble preparations which have been reported previously. Interestingly, the particulate preparation could be stimulated about fourfold by a soluble brain extract in the presence of 1 mM guanosine triphosphate, confirming that the enzyme is the catalytic subunit in a membrane-bound signal-transduction system.     

Multiple-wavelength integration in InGaAs-InGaAsP structures using pulsed laser irradiation-induced quantum-well intermixing

In this paper, we present the characteristics of a quantum-well intermixing technique using pulsed-photoabsorption-induced disordering. Photoluminescence, micro-Raman spectroscopy, and transmission electron microscopy were used to characterize the process. Using this technique, a differential wavelength shift between the intermixed and nonintermixed regions of over 160 nm has been observed from InGaAs-InGaAsP heterostructures. It was found from the micro-Raman measurements that a spatial resolution of better than 2.5 /spl mu/m can be achieved. A theoretical model has been developed to estimate the spatial resolution limit. Theoretical analysis has also been performed to investigate the effect of laser irradiation on the degree of intermixing in InGaAs-InGaAsP structures. To verify the capability of this process in monolithic photonic integration, high-quality bandgap tuned lasers, two-section extended cavity lasers, and multiple-wavelength laser chips have been fabricated.     

The treatment of thin wires in the FDTD method using a weighted residuals approach

In this contribution, the problem of accurately representing thin wires within the finite-difference time-domain (FDTD) mesh is addressed by means of a method based on the weighted residual (WR) interpretation of the FDTD algorithm. Results for wire dipoles and wire transmission lines, obtained using the proposed method, are presented and compared to those obtained using existing techniques. It is shown that the proposed method yields results which are more accurate and are less dependent on the choice of cell size than other approaches and, in addition, lends itself well to being extended for more complicated structures. Details of the calculation of the update equations are given.     

Resistance of Listeria monocytogenes, Escherichia coli O157:H7 and Campylobacter jejuni after exposure to repetitive cycles of mild bactericidal treatments

While maintaining nutritional and sensorial attributes of fresh foods mild processing technologies generally deliver microbiologically perishable food products. Currently little information exists on possible increase in the resistance of pathogens after repetitive exposure to mild (sub-lethal) treatments. Multiple strain-cocktails of Listeria monocytogenes, Escherichia coli O157:H7 and Campylobacter jejuni were exposed to 20 consecutive cycles of sub-lethal inactivation by three different techniques. Used techniques comprised inactivation with lactic acid (LA), chlorine dioxide (ClO₂) and intense light pulses (ILP). Results showed that the selection of resistant cells was both species and technique dependent. While repetitive cycles of ClO₂ treatment did not result in increased resistance, repetitive inactivation with LA yielded L. monocytogenes culture of higher resistance in comparison to the parental culture. The increased resistance, expressed as decreased level of reduction in bacterial counts in subsequent inactivation cycles, was also observed with ILP for both L. monocytogenes and E. coli O157:H7 strains. Visual trend observations were confirmed through statistical linear regression analysis. No such effects were noted for C. jejuni which became undetectable after first 2–5 cycles. Current findings indicate the ability of foodborne pathogens to adapt to mild bactericidal treatments creating new challenges in risk assessment and more specifically in hazard analysis.     

Optimizing glutaraldehyde crosslinking of collagen: effects of time,temperature and concentration as measured by shrinkage temperature

Glutaraldehyde (GA) crosslinking (fixation) of collageneous tissues is a widely used method for the preparation of implantible tissues to be used as biomaterials. In an attempt to optimize the fixation process, experiments were carried out with two types of collagen (native collagen membrane and synthetic collagen sheet) to study the effect on crosslinking of temperature, GA concentration and fixation time. Secondly, stimulation of GA diffusion was studied and finally, a procedure of low T-presoaking followed by brief exposure to high temperatures was investigated. As a measure of the degree of crosslinking the shrinkage temperature (T _s) was determined. Temperature (20°C or 45°C), concentration (0.1% or 1.0%) or fixation time (4 or 24 h) were found to be positively correlated with the T _s of the collagen sheets. Whereas untanned collagen exhibits a T _s of around 60°C, short-term (1 or 5 min), high-temperature (50°C) fixation with a 0.1% GA solution caused the shrinkage temperature to increase to 72°C and 85.1°C, respectively. Fixation with 0.01% GA for 5 min at 50°C appeared equally effective as 1 min with 0.1% GA (T _s=70°C). Microwave irradiation showed to be slightly more effective in enhancing the crosslinking process compared with conventional heating. Surprisingly, at any combination of temperature, concentration and fixation periods of 4 h or 24 h, an increased T _s towards the central regions of the collagen was observed. Soaking the samples at 20°C (1 h) or at 0°C (3 h) with subsequent short-time heating to 45°C caused an almost equal rise in T _s throughout the collagen samples and is therefore recommended for preparing implantable tissues.     

Vulcan--A versatile high-power glass laser for multiuser experiments

This paper reports the design and characterization of the newly upgraded Nd:glass laser facility at the Rutherford Laboratory. Emphasis is placed on the unusual aspects consequent on its role as a multiuser facility, where reliability and flexibility are of paramount importance. The basic facility configuration is of two high-power laser systems in parallel-a six-beam laser for implosion experiments and a separate high-power single beamline for either X-ray backlighting diagnostics of implosion experiments or use in a separate single-beam target area. Additional flexibility is provided by remotely controlled changeover mirrors enabling groups of amplifiers to be used in different combinations for various energies and shot repetition rates. Either a mode-locked or aQ-switched oscillator can be selected to provide a range of pulse durations from 50 ps to many nanoseconds. Harmonic generation is used routinely to give a choice of wavelengths for different experiments. The six-beam system is normally run at the second harmonic, although the fundamental wavelength is also available, while the single-beam target area can use fundamental, second, or third harmonics.     

IT2000: A critical appraisal of Singapore's state-wide strategic planning process for information technology

In April 1992, the Singapore Government announced its information technology (IT) vision and plan for the next 15 years to turn Singapore into ‘an intelligent island’, providing a strategic regional switching centre for expertise, goods, services and information. At the heart of this plan is a national information infrastructure that would capitalize on information as a key factor of production and an important ingredient for enhancing the quality of life of its people. Code named ‘IT2000’, the plan was developed by 60 senior managers at the National Computer Board in 1991 with participation and inputs from about 200 business and industry leaders, domain experts and academics. This paper describes the background of Singapore's drive into the information age, the IT2000 planning process, the roles of various participants and the main recommendations of the plan. An evaluation of IT2000 is made in terms of its objectives, its unanticipated results and its impacts on industry participants. Implications and lessons are drawn for strategic IT planning at the national or sectoral level.     

The impact of river regulation on invertebrate communities in the U.K.

The impact of river regulation on invertebrates has received comparatively little attention in the U.K., with most studies concentrating on the effects of impoundment. During dam construction invertebrate diversity and abundance decreases. Longer term alterations in community structure (which usually extend for a relatively short distance downstream) reflect changes in flow, substrate, temperature, and water quality. In particular adverse effects on invertebrates have been attributed to a reduction in substrate heterogeneity together with an accumulation of sediment. Responses to impoundment within and between taxonomic groups are highly variable. In general Ephemeroptera and Coleoptera are reduced. Of the Plecoptera the Perlodidae and Chloroperlidae are more likely to be adversely affected than the Nemouridae or Leuctridae. The impact of impoundment on net-spinning Trichoptera varies with reductions in some populations and enhancement in others. Simuliids are usually restricted, probably because of a lack of suitable oviposition or attachment sites. Freshets released from reservoirs increase the level of invertebrate drift. However, the full consequences of impoundment on drift, recolonization, and upstream migration have yet to be assessed. There is some evidence that modified temperature regimes cause extended egg hatching periods and alter larval growth rates but further studies are needed. Little is known of the effects of inter-river transfers on invertebrates, but it has been suggested that changes in flow velocity, water chemistry, suspended solids, and temperature together with translocation of organisms are all likely to be important. The limited information available for groundwater schemes indicates that they are not detrimental to invertebrates. Their impact, however, is dependent upon factors such as the extent and timing of flow augmentation. It is suggested that there is scope for positive management of invertebrate communities through river regulation, although at present attitudes and practices do not encourage this. Many gaps in our knowledge still remain and these are discussed in relation to future research needs.