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排序方式: 共有559条查询结果,搜索用时 548 毫秒
101.
Caroline Murawski Andreas Mischok Jonathan Booth Jothi Dinesh Kumar Emily Archer Laura Tropf Chang‐Min Keum Ya‐Li Deng Kou Yoshida Ifor D. W. Samuel Marcel Schubert Stefan R. Pulver Malte C. Gather 《Advanced materials (Deerfield Beach, Fla.)》2019,31(42)
Fluorescence imaging is an indispensable tool in biology, with applications ranging from single‐cell to whole‐animal studies and with live mapping of neuronal activity currently receiving particular attention. To enable fluorescence imaging at cellular scale in freely moving animals, miniaturized microscopes and lensless imagers are developed that can be implanted in a minimally invasive fashion; but the rigidity, size, and potential toxicity of the involved light sources remain a challenge. Here, narrowband organic light‐emitting diodes (OLEDs) are developed and used for fluorescence imaging of live cells and for mapping of neuronal activity in Drosophila melanogaster via genetically encoded Ca2+ indicators. In order to avoid spectral overlap with fluorescence from the sample, distributed Bragg reflectors are integrated onto the OLEDs to block their long‐wavelength emission tail, which enables an image contrast comparable to conventional, much bulkier mercury light sources. As OLEDs can be fabricated on mechanically flexible substrates and structured into arrays of cell‐sized pixels, this work opens a new pathway for the development of implantable light sources that enable functional imaging and sensing in freely moving animals. 相似文献
102.
Impedance spectroscopy of bismuth sodium titanate: Barium titanate ceramics with manganese doping 下载免费PDF全文
V. Hugo Schmidt Noah Archer Chi‐Shun Tu 《Journal of the American Ceramic Society》2018,101(2):713-722
In this work we use Impedance Spectroscopy (IS) to study lead‐free ceramics of perovskite structure (Bi1/2Na1/2TiO3)0.925(BaTiO3)0.075 with Mn doping of 0, 0.2, 1.0, and 2.0 at.%. We compare our IS results with permittivity results, using dielectric to resistivity transformation equations which allow us to display results either as permittivity or as resistivity. We observe ionic conductivity dominating at lower temperatures, giving way to electronic conductivity at higher temperatures. The permittivity shows deviations from Curie‐Weiss behavior characteristic of relaxor ferroelectrics. The 0.2% Mn samples show the highest ionic resistivity, which will reduce heating for high voltage piezoelectric applications. They also have the highest Curie‐Weiss temperature and Burns temperature. 相似文献
103.
Comparing the input, output, and validation maps for several models of land change 总被引:31,自引:0,他引:31
Robert Gilmore Pontius Jr Wideke Boersma Jean-Christophe Castella Keith Clarke Ton de Nijs Charles Dietzel Zengqiang Duan Eric Fotsing Noah Goldstein Kasper Kok Eric Koomen Christopher D. Lippitt William McConnell Alias Mohd Sood Bryan Pijanowski Snehal Pithadia Sean Sweeney Tran Ngoc Trung A. Tom Veldkamp Peter H. Verburg 《The Annals of Regional Science》2008,42(1):11-37
This paper applies methods of multiple resolution map comparison to quantify characteristics for 13 applications of 9 different
popular peer-reviewed land change models. Each modeling application simulates change of land categories in raster maps from
an initial time to a subsequent time. For each modeling application, the statistical methods compare: (1) a reference map
of the initial time, (2) a reference map of the subsequent time, and (3) a prediction map of the subsequent time. The three
possible two-map comparisons for each application characterize: (1) the dynamics of the landscape, (2) the behavior of the
model, and (3) the accuracy of the prediction. The three-map comparison for each application specifies the amount of the prediction’s
accuracy that is attributable to land persistence versus land change. Results show that the amount of error is larger than
the amount of correctly predicted change for 12 of the 13 applications at the resolution of the raw data. The applications
are summarized and compared using two statistics: the null resolution and the figure of merit. According to the figure of
merit, the more accurate applications are the ones where the amount of observed net change in the reference maps is larger.
This paper facilitates communication among land change modelers, because it illustrates the range of results for a variety
of models using scientifically rigorous, generally applicable, and intellectually accessible statistical techniques. 相似文献
104.
David R. Archer MCIWEM Francois Leesch & Kirsty Harwood 《Water and Environment Journal》2007,21(2):133-141
Extreme floods often demonstrate unanticipated characteristics that pose problems for management and response. The floods on the Tyne and Eden in January 2005 provided numerous examples of such unexpected response. This paper describes characteristics of storm rainfall and runoff generation on the River Tyne catchment, flood effects and damage. Unusual aspects of hydrological behaviour are highlighted as a basis for assessing what lessons can be learned for flood risk management. These include problems associated with coincidence of extreme wind speeds and rainfall, the retarding influence of floodplain storage on flood wave travel time in extreme flows, the influence of critical storm duration on the severity of the resulting flood on headwaters and main river, and the variety of mechanisms of flood occurrence. The occurrence of such an extreme flood provides the opportunity to validate and enhance the review process of the Environment Agency's flood zone maps. 相似文献
105.
Ori Geuli Noah Metoki Noam Eliaz Daniel Mandler 《Advanced functional materials》2016,26(44):8003-8010
Calcium phosphates are of great interest for biomedical applications such as bone tissue engineering, bone fillers, drug and gene delivery, and orthopedic and dental implant coating. Here, the first electrochemically driven coating of medical implants using hydroxyapatite (HAp) nanoparticles (NPs) as building blocks is reported. This uncommon combination offers a simple, straightforward, and economic process with well controllable, pure, single‐phase HAp. Crystalline, pure HAp NPs are formed by precipitation reaction. The HAp NPs are dispersed by either citrate or poly(acrylic acid) to form pH sensitive dispersion. Controllable and homogeneous coating of medical implants is accomplished by altering the pH on the surface upon applying either a constant potential or current. The process involves protonation of the carboxylic acid moieties, which causes the irreversible aggregation of the HAp NPs due to diminishing the repulsive forces between the particles. Deposition is further demonstrated on a commercial dental implant. Moreover, the adhesion of the coating satisfies FDA and international standard requirements. A porous interconnected network of bone‐like HAp layer is formed during soaking in a simulated body fluid for 30 d and is similar to bone generation, and it therefore holds promise for further in vivo testing. 相似文献
106.
Byungho Min Noah Hae-Woong Yang Samuel Palermo 《Analog Integrated Circuits and Signal Processing》2016,86(2):233-240
Crosstalk between neighboring channels can have significant impact on system bit-error rate (BER) as serial I/O data rates scale above 10 Gb/s. This paper presents receive-side circuitry which merges the cancellation of both near-end and far-end crosstalk (NEXT/FEXT) and can automatically adapt to different channel environments and variations in process, voltage, and temperature. NEXT cancellation is realized with a novel 3-tap FIR filter which combines two traditional FIR filter taps and a continuous-time band-pass filter IIR tap for efficient crosstalk cancellation, with all filter tap coefficients automatically determined via an on-die sign–sign least-mean-square (SS-LMS) adaptation engine. FEXT cancellation is realized by coupling the aggressor signal through a differentiator circuit whose gain is automatically adjusted with a power-detection-based adaptation loop. A prototype fabricated in a general purpose 65-nm CMOS process includes the adaptive NEXT and FEXT circuitry, along with a continuous-time linear equalizer (CTLE) to compensate for frequency-dependent channel loss. Enabling the crosstalk cancellation circuitry while operating at 10 Gb/s over coupled 4-in FR4 transmission line channels with NEXT and FEXT aggressors opens a previously closed eye and allows for a 0.2 UI timing margin at a BER = 10?9. Total power including the NEXT/FEXT crosstalk cancellation circuitry, CTLE, and high-speed output buffer is 34.6 mW, and the core circuit area occupies 0.3 mm2. 相似文献
107.
This study investigates two methods of transforming intermittent wind electricity into firm baseload capacity: (1) using electricity from natural gas combined-cycle (NGCC) power plants and (2) using electricity from compressed air energy storage (CAES) power plants. The two wind models are compared in terms of capital and electricity costs, CO2 emissions, and fuel consumption rates. The findings indicate that the combination of wind and NGCC power plants is the lowest-cost method of transforming wind electricity into firm baseload capacity power supply at current natural gas prices (∼$6/GJ). However, the electricity supplied by wind and CAES power plants becomes economically competitive when the cost of natural gas for electric producers is $10.55/GJ or greater. In addition, the Wind-CAES system has the lowest CO2 emissions (93% and 71% lower than pulverized coal power plants and Wind-NGCC, respectively) and the lowest fuel consumption rates (9 and 4 times lower than pulverized coal power plants and Wind-NGCC, respectively). As such, the large-scale introduction of Wind-CAES systems in the U.S. appears to be the prudent long-term choice once natural gas price volatility, costs, and climate impacts are all considered. 相似文献
108.
Giam LR He S Horwitz NE Eichelsdoerfer DJ Chai J Zheng Z Kim D Shim W Mirkin CA 《Nano letters》2012,12(2):1022-1025
We report the first method for synthesizing binary semiconductor materials by scanning probe block copolymer lithography (SPBCL) in desired locations on a surface. In this work, we utilize SPBCL to create polymer features containing a desired amount of Cd(2+), which is defined by the feature volume. When they are subsequently reacted in H(2)S in the vapor phase, a single CdS nanoparticle is formed in each block copolymer (BCP) feature. The CdS nanoparticles were shown to be both crystalline and luminescent. Importantly, the CdS nanoparticle sizes can be tuned since their diameters depend on the volume of the originally deposited BCP feature. 相似文献
109.
Bruce Noah; Manber Rachel; Shapiro Shauna; Constantino Michael 《Canadian Metallurgical Quarterly》2010,47(2):168
Reports an error in Psychotherapist mindfulness and the psychotherapy process by Noah G. Bruce, Rachel Manber, Shauna L. Shapiro and Michael J. Constantino (Psychotherapy: Theory, Research, Practice, Training, 2010[Mar], Vol 47[1], 83-97). The order of authorship and the affiliations of the authors was incorrectly printed. The correct order and affiliations are as follows: Noah Bruce, Shauna L. Shapiro, Michael J. Constantino, and Rachel Manber; Kaiser Permanente, Santa Clara University, University of Massachusetts, Stanford University. (The following abstract of the original article appeared in record 2010-05168-010.) A psychotherapist’s ability to relate to his or her patients is essential for decreasing patient suffering and promoting patient growth. However, the psychotherapy field has identified few effective means for training psychotherapists in this ability. In this conceptual article, we propose that mindfulness practice may be a means for training psychotherapists to better relate to their patients. We posit that mindfulness is a means of self-attunement that increases one’s ability to attune to others (in this case, patients) and that this interpersonal attunement ultimately helps patients achieve greater self-attunement that, in turn, fosters decreased symptom severity, greater well-being, and better interpersonal relationships. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
110.
Dynameomics: design of a computational lab workflow and scientific data repository for protein simulations 总被引:1,自引:0,他引:1
Simms AM Toofanny RD Kehl C Benson NC Daggett V 《Protein engineering, design & selection : PEDS》2008,21(6):369-377
Dynameomics is a project to investigate and catalog the native-state dynamics and thermal unfolding pathways of representatives of all protein folds using solvated molecular dynamics simulations, as described in the preceding paper. Here we introduce the design of the molecular dynamics data warehouse, a scalable, reliable repository that houses simulation data that vastly simplifies management and access. In the succeeding paper, we describe the development of a complementary multidimensional database. A single protein unfolding or native-state simulation can take weeks to months to complete, and produces gigabytes of coordinate and analysis data. Mining information from over 3000 completed simulations is complicated and time-consuming. Even the simplest queries involve writing intricate programs that must be built from low-level file system access primitives and include significant logic to correctly locate and parse data of interest. As a result, programs to answer questions that require data from hundreds of simulations are very difficult to write. Thus, organization and access to simulation data have been major obstacles to the discovery of new knowledge in the Dynameomics project. This repository is used internally and is the foundation of the Dynameomics portal site http://www.dynameomics.org. By organizing simulation data into a scalable, manageable and accessible form, we can begin to address substantial questions that move us closer to solving biomedical and bioengineering problems. 相似文献