全文获取类型
收费全文 | 261篇 |
免费 | 8篇 |
国内免费 | 1篇 |
专业分类
化学工业 | 82篇 |
金属工艺 | 20篇 |
机械仪表 | 7篇 |
建筑科学 | 3篇 |
能源动力 | 3篇 |
轻工业 | 13篇 |
石油天然气 | 53篇 |
无线电 | 24篇 |
一般工业技术 | 42篇 |
冶金工业 | 15篇 |
原子能技术 | 3篇 |
自动化技术 | 5篇 |
出版年
2022年 | 11篇 |
2021年 | 23篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 11篇 |
2014年 | 6篇 |
2013年 | 6篇 |
2012年 | 4篇 |
2011年 | 16篇 |
2010年 | 10篇 |
2009年 | 10篇 |
2008年 | 4篇 |
2007年 | 7篇 |
2006年 | 8篇 |
2005年 | 2篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 6篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有270条查询结果,搜索用时 31 毫秒
251.
Daniel Granato Predrag Putnik Danijela Bursać Kovačević Jânio Sousa Santos Verônica Calado Ramon Silva Rocha Adriano Gomes Da Cruz Basil Jarvis Oxana Ye Rodionova Alexey Pomerantsev 《Comprehensive Reviews in Food Science and Food Safety》2018,17(3):663-677
In the last decade, the use of multivariate statistical techniques developed for analytical chemistry has been adopted widely in food science and technology. Usually, chemometrics is applied when there is a large and complex dataset, in terms of sample numbers, types, and responses. The results are used for authentication of geographical origin, farming systems, or even to trace adulteration of high value‐added commodities. In this article, we provide an extensive practical and pragmatic overview on the use of the main chemometrics tools in food science studies, focusing on the effects of process variables on chemical composition and on the authentication of foods based on chemical markers. Pattern recognition methods, such as principal component analysis and cluster analysis, have been used to associate the level of bioactive components with in vitro functional properties, although supervised multivariate statistical methods have been used for authentication purposes. Overall, chemometrics is a useful aid when extensive, multiple, and complex real‐life problems need to be addressed in a multifactorial and holistic context. Undoubtedly, chemometrics should be used by governmental bodies and industries that need to monitor the quality of foods, raw materials, and processes when high‐dimensional data are available. We have focused on practical examples and listed the pros and cons of the most used chemometric tools to help the user choose the most appropriate statistical approach for analysis of complex and multivariate data. 相似文献
252.
Ekaterina Blinova Elena Samishina Olga Deryabina Dmitry Blinov Dmitry Roshchin Evgeniia Shich Oxana Tumutolova Ilya Fedoseykin Anna Epishkina Haydar Barakat Andrey Kaprin Kirill Zhandarov Dmitrij Perepechin Dmitrij Merinov Gordey Brykin Karen Arutiunian Stanislav Serebrianyi Artem Mirontsev Andrew Kozdoba 《International journal of molecular sciences》2021,22(18)
Background: The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3 expression, and its gene mutation status for the therapeutic success of anti-PD-L1 treatment in the patient-derived murine model of recurrent high-PD-L1(+) GATA3(−)/CR5/6(−) high-grade and low-grade NMIBC. Methods: twenty lines of patient-derived xenografts (PDXs) of relapsed high-PD-L1(+) double-negative NMIBC were developed, of which 10 lines represented high-grade tumors and the other ones—low-grade bladder cancer. Acceptors of each grade-related branch received specific anti-PD-L1 antibodies. Animals’ survival, tumor-doubling time, and remote metastasis were followed during the post-interventional period. PD-L1, GATA3, CR5/6, and p53 protein expressions in engrafted tumors were assessed by immunohistochemistry. The FGFR3 expression and FGFR3 mutations in codons 248 and 249 were detected by real-time polymerase chain reaction. Results: The expression of p53 protein is an independent factor affecting the animals’ survival time [HR = 0.036, p = 0.031] of anti-PD-L1-treated mice with low-grade high-PD-L1(+) double-negative NMIBC PDX. The FGFR3 expression and FGFR3 mutation rate have no impact on the anti-PD-L1 treatment response in the interventional groups. Conclusions: p53 expression may be considered as a prognostic factor for the anti-PD-L1 treatment efficacy of low-grade high-PD-L1-positive GATA3(−)/CR5/6(−)-relapsed noninvasive bladder cancer. 相似文献
253.
254.
Berezhnaya NM Kovalchuk EV Vinnichuk YD Spivak SI Belova OB 《Eksperimental?nai?a onkologii?a》2004,26(1):63-66
AIM: To compare the sensitivity of doxorubicin (DOX) sensitive and DOX-resistant MC-rhabdomyosarcoma (MC-RMS) cells to the action of lymphokine-activated cells (LAC). RESULTS: In vitro investigations showed that LAC received from the fraction of adherent lymphocytes possess the highest activity against DOX-resistant tumor cells, and LAC from lymphocytes of total pool--against DOX-resistant tumor cells pretreated with DOX at a low dose. Adoptive immunotherapy of MC-RMS in vivo showed the highest efficacy in the cases of LAC intratumoral injection and the one combined with intraperitoneal administration of DOX at a low dose (increase of survival time by 14% and 25%, respectively). CONCLUSION: Adoptive in vivo therapy of DOX-resistant Mh-RMS is effective if LAC or their combination with DOX at a low dose are administered. 相似文献
255.
256.
The authors studied hormonal regulation of carbohydrate metabolism by secretion of insulin, C-peptide in 86 patients with chronic glomerulonephritis with different functional condition of the kidneys. There was a decrease in glucose tolerance, basal and reactive hyperinsulinemia, elevated level of C-peptide (relative insulin insufficiency). Mechanism of arising changes in the carbohydrate and insulin metabolism is complex and multicomponent. This includes renal lesion and consequent inhibition of hormone metabolism. Intensification of glomerular filtration is associated with inhibition of filtration of insulin and C-peptide derivants. Accumulation of nitrogen metabolism products results in changed response of pancreatic beta-cells to glucose. General disturbances of metabolism are accompanied by increasing levels of hormonal and nonhormonal contrainsular substances. 相似文献
257.
258.
259.
260.