Detailed measurements of the flow instability of dilute shear-thinning viscoelastic aqueous solutions, with relatively low zero-shear viscosities, in an obstructed microchannel flow are reported. We examine the flow behaviour resulting from a 100 μm post placed in the channel centreline over a range of Reynolds numbers (\(5<Re<300\)) and Weissenberg numbers (\(20<Wi<10^3\)). Micro-particle image velocimetry measurements show the onset of an upstream instability within a Reynolds number range and at a critical elasticity number corresponding to polymer concentrations above 25 ppm of long-chain polyacrylamide. The instability results in significant local fluctuations in the flow field approaching 30 % of the mean velocity. The magnitude of the local viscosity ratio in the region upstream of the post is proposed as a driving mechanism for the instability which resembles a buckling flow. Additionally, the classical instability owing to separation and vortex formation downstream of the post in Newtonian flow is suppressed and a very long stable wake is observed extending over 10 post-diameters downstream. 相似文献
Given a set of points with uncertain locations, we consider the problem of computing the probability of each point lying on the skyline, that is, the probability that it is not dominated by any other input point. If each point’s uncertainty is described as a probability distribution over a discrete set of locations, we improve the best known exact solution. We also suggest why we believe our solution might be optimal. Next, we describe simple, near-linear time approximation algorithms for computing the probability of each point lying on the skyline. In addition, some of our methods can be adapted to construct data structures that can efficiently determine the probability of a query point lying on the skyline. 相似文献
Wireless Personal Communications - Finding the best path between a given source and a destination in a road network is an important problem. It has its applications in various map services and... 相似文献
Change point detection algorithms have numerous applications in areas of medical condition monitoring, fault detection in industrial processes, human activity analysis, climate change detection, and speech recognition. We consider the problem of change point detection on compositional multivariate data (each sample is a probability mass function), which is a practically important sub-class of general multivariate data. While the problem of change-point detection is well studied in univariate setting, and there are few viable implementations for a general multivariate data, the existing methods do not perform well on compositional data. In this paper, we propose a parametric approach for change point detection in compositional data. Moreover, using simple transformations on data, we extend our approach to handle any general multivariate data. Experimentally, we show that our method performs significantly better on compositional data and is competitive on general data compared to the available state of the art implementations.
Hybrid composites of layered brittle‐ductile constituents assembled in a brick‐and‐mortar architecture are promising for applications requiring high strength and toughness. Mostly, polymer mortars have been considered as the ductile layer in brick‐and‐mortar composites. However, low stiffness of polymers does not efficiently transfer the shear between hard ceramic bricks. Theoretical models point to metals as a more efficient mortar layer. However, infiltration of metals into ceramic scaffold is non‐trivial, given the low wetting between metals and ceramics. The authors report on an alternative approach to fabricate brick‐and‐mortar ceramic‐metal composites by using electroless plating of nickel (Ni) on alumina micro‐platelets, in which Ni‐coated micro‐platelets are subsequently aligned by a magnetic field, taking advantage of ferromagnetic properties of Ni. The assembled Ni‐coated ceramic scaffold is then sintered using spark plasma sintering (SPS) to locally create Ni mortar layers between ceramic platelets, as well as to sinter the ceramic micro‐platelets. The authors report on materials and mechanical properties of the fabricated composite. The results show that this approach is promising toward development of bioinspired ceramic‐metal composites. 相似文献
Complete drug release and efficient drug retention are two critical factors in reversing drug resistance in cancer therapy. In this regard, polymeric micelles with an upper critical solution temperature (UCST) are designed as a new exploration to reverse drug resistance. The amphiphilic UCST‐type block copolymers are used to encapsulate photothermal agent IR780 and doxorubicin (DOX) simultaneously. The integrated UCST‐type drug nanocarriers show light‐triggered multiple synergistic effects to reverse drug resistance and are expected to kill three birds with one stone: First, owing to the photothermal effect of IR780, the nanocarriers will be dissociated upon exposure to laser irradiation, leading to complete drug release. Second, the photothermal effect‐induced hyperthermia is expected to avoid the efflux of DOX and realize efficient drug retention. Last but not least, photothermal ablation of cancer cells can be achieved after laser irradiation. Therefore, the UCST‐type drug nanocarriers provide a new strategy in reversing drug resistance in cancer therapy. 相似文献
An accurate finite-volume based numerical method for the simulation of an isothermal two-phase flow, consisting of a rising deformable bubble translating in a quiescent, unbounded liquid, is presented. This direct simulation method is built on a sharp interface concept and developed on an Eulerian, Cartesian fixed-grid with a cut-cell scheme and marker points to track the moving interface. The unsteady Navier–Stokes equations in both liquid and gas phases are solved separately. The mass continuity and momentum flux conditions are explicitly matched at the true surface phase boundary to determine the evolving interface shape and movement of the bubble. The highlights of this method are that it utilizes a combined Eulerian–Lagrangian approach, and is capable of treating the interface as a sharp discontinuity. A fixed underlying grid is used to represent the control volume. The interface, however, is denoted by a separate set of marker particles which move along with the interface. A quadratic curve fitting algorithm with marker points is used to yield smooth and accurate information of the interface curvatures. This numerical scheme can handle a wide range of density and viscosity ratios. The bubble is assumed to be spherical and at rest initially, but deforms as it rises through the liquid pool due to buoyancy. Additionally, the flow is assumed to be axisymmetric and incompressible. The bubble deformation and dynamic motion are characterized by the Reynolds number, the Weber number, the density ratio and the viscosity ratio. The effects of these parameters on the translational bubble dynamics and shape are given and the physical mechanisms are explained and discussed. Results for the shape, velocity profile and various forces acting on the bubble are presented here as a function of time until the bubble reaches terminal velocity. The range of Reynolds numbers investigated is 1 < Re < 100, and that of Weber number is 1 < We < 10. 相似文献