Machine Learning for Cataract Classification/Grading on Ophthalmic Imaging Modalities: A Survey

Cataracts are the leading cause of visual impairment and blindness globally. Over the years, researchers have achieved significant progress in developing state-of-the-art machine learning techniques for automatic cataract classification and grading, aiming to prevent cataracts early and improve clinicians’ diagnosis efficiency. This survey provides a comprehensive survey of recent advances in machine learning techniques for cataract classification/grading based on ophthalmic images. We summarize existing literature from two research directions: conventional machine learning methods and deep learning methods. This survey also provides insights into existing works of both merits and limitations. In addition, we discuss several challenges of automatic cataract classification/grading based on machine learning techniques and present possible solutions to these challenges for future research.

     

Division of labor among lesbian and heterosexual parents: Associations with children's adjustment.

This study compared lesbian and heterosexual parents' division of household labor, satisfaction with division of labor, satisfaction with couple relationships, and associations of these variables with psychological adjustment of children. Participating lesbian (n?=?30) and heterosexual (n?=?16) couples all became parents by using anonymous donor insemination and had at least 1 child of elementary-school age. Although both lesbian and heterosexual couples reported relatively equal divisions of paid employment and of household and decision-making tasks, lesbian biological and nonbiological mothers shared child-care tasks more equally than did heterosexual parents. Among lesbian nonbiological mothers, those more satisfied with the division of family decisions in the home were also more satisfied with their relationships and had children who exhibited fewer externalizing behavior problems. The effect of division of labor on children's adjustment was mediated by parents' relationship satisfaction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Successful management for chemorefractory testicular cancer with brain and lung metastases. A case report

This is a report of successful management for a far advanced, chemorefractory testicular cancer patient. A 29-year-old male was referred to our hospital for the treatment of progressive lung metastases with elevated hCG level, which had recurred after complete remission following 3 courses of BEP chemotherapy and progressed after transient partial regression following 2 courses of intensified EP chemotherapy. In addition, a 3 cm in diameter, solitary brain metastasis was detected on CT. First, we performed wedge resection of bilateral pulmonary lower lobe for chemorefractory pulmonary metastases. Histological examination revealed viable embryonal carcinoma identical to the primary one. Thereafter, whole brain irradiation in combination with VIP chemotherapy (etoposide 100 mg/m2, cisplatin 20 mg/m2 and ifosfamide 1200 mg/m2 daily for 5 consecutive days) was carried out to treat brain metastasis. By 2 cycles of VIP therapy and irradiation (36 Gy), partial tumor regression and normalization of hCG level were achieved, leading to salvage surgery of the brain metastasis which histologically proved to be necrosis. Following an additional cycle of VIP therapy, the patient has been free of recurrence 24 months after completion of the treatment.     

Facilitation of passive avoidance response by newly synthesized cationized arginine vasopressin fragment 4-9 in rats

The effects of a newly synthesized cationized arginine vasopressin fragment 4-9 analogue (C-AVP-(4-9)) on learning and memory in rats were studied by the passive avoidance test. C-AVP-(4-9) and its parent peptide, arginine vasopressin fragment 4-9 (AVP-(4-9)), a well known potent neuropeptide, were subcutaneously injected 1.5 hr prior to the retention test. The most effective doses of C-AVP-(4-9) and AVP-(4-9) were 8.6 x 10(-2) and 1.3 nmol/kg, respectively. To evaluate the distribution of C-AVP-(4-9) in the control nervous system (CNS), apparent tissue-plasma concentration rations (Kp.app) of intravenously administered radioiodinated C-AVP-(4-9) (125I-C-AVP-(4-9)) in the CNS in mice were determined. At the apparent steady state of plasma concentration of 125I-C-AVP-(4-9), the Kp.app values of the 125I-C-AVP-(4-9) in the cerebrum, cerebellum and spinal cord were over 12 times higher than that of the vascular space marker which slightly penetrates the BBB. Moreover, the rat cerebral homogenate converted C-AVP-(4-9) into its parent peptide AVP-(4-9). These results suggest that the potent effects of C-AVP-(4-9) on learning and memory may be due to AVP-(4-9) generated as a result of distribution and metabolism of peripherally administered C-AVP-(4-9) in the CNS.     

Doping Effects in Rare-Earth Borides

Boron-rich cluster compounds are studied for their potential as high-temperature thermoelectric materials with low thermal conductivity. Two B₁₂ icosahedra systems with attractive thermoelectric properties have recently been discovered: p-type REB₄₄Si₂ (where RE stands for rare earth) and the anomalous n-type series of RE-B-C(N) homologous compounds. Three different doping effects of these compounds were investigated in this work in an attempt to control the properties: doping disorder into REB₄₄Si₂, which is a variable-range hopping system, V-doping of YB₄₄Si₂, and C-doping (carbon composition control) of YB_28.5C₄. The attempt to enhance the Seebeck coefficient in TbB₄₄Si₂ through disorder was inconclusive, while V-doping of YB₄₄Si₂ had a negative effect on the thermoelectric properties. Controlling the carbon composition of YB_28.5C₄ appeared to be a promising route for increasing the absolute value of the Seebeck coefficient.