Assessing Environmental Risks: Lessons From Superfund

This essay analyzes the use of risk assessment in Superfund, the controversial American hazardous waste cleanup programme. We argue that risk assessment has been used in three ways in discussing policy options in this programme: as a metric for assessing performance; as a means for resolving conflicts; and as a tool for comparing different environmental initiatives. Use of risk reduction as an analytical tool in European efforts to clean up hazardous waste sites is discussed. We conclude that while risk assessment has potential utility for each of these applications, there are also accompanying technical and political difficulties.     

Isoforms p69 and p100 of 2'',5''-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro

There is no better place to test life-saving resuscitation interventions than in the prehospital setting. Patients rarely survive cardiac arrest if resuscitation techniques have failed before leaving the scene. Also, paramedics are usually very experienced in key initial resuscitative techniques, and they routinely operate under strict paramilitary protocol, resulting in better study compliance. In addition, the large study populations that are derived from emergency medical services (EMS) systems lead to faster study completion and statistically stronger data. Most important, by reinforcing standardized care, rigidly scrutinized trials improve patient care, regardless of the effect of the study intervention. The success of productive EMS research centers requires routine communication between hospital and EMS administrators and their medical directors, designation of mutually acceptable data collectors who guarantee confidentiality, reciprocal exchange of study data provided as educational seminars to the hospitals, commitments to support the budget requests of an EMS program and appropriate system modifications, inclusion of EMS personnel in study design from the very beginning, prospective education of the medical community and media before protocol implementation, an authoritative grassroots medical director, and a paramedic supervisor system.     

Interleukin 8 (IL-8) induces the expression of kinin B1 receptor in human lung fibroblasts

Near-haploidy is a rare cytogenetic finding in childhood acute lymphoblastic leukaemia (ALL) and is associated with a poor prognosis. A second hyperdiploid line, occurring presumably by endoreduplication of the near-haploid stemline, is often observed. We present a case of common ALL in relapse characterized morphologically by a dual population of small and large lymphoblasts. Cytogenetic analysis supplemented with fluorescence in-situ hybridization (FISH) studies localized near-haploidy and hyperdiploidy to the small and large blast population respectively. DNA ploidy determination confirmed two abnormal clones with near-haploidy as the predominant one. A novel t(9;12)(q11;q13) was present in the near-haploid clone and was duplicated in the hyperdiploid clone. This finding identified cells bearing near-haploidy to be the clonogenic population following malignant transformation and confirmed endoreduplication as the mechanism for the presence of associated hyperdiploidy.     

The US market for SO2 permits: Policy implications of the low price and trading volume

The price of SO₂ permits and the volume of trading under the US Acid Rain Program have been lower than expected. This can be explained by the creation and distribution of more permits than were initially authorized, by the sale of permits by high cost abaters who are subject to more stringent local emission constraints or who have irreversibly invested in high cost abatement technologies and by the deregulation of the natural gas and railroad industries which, in combination with incentives for cost-cutting under the new market approach to SO₂ control, has lowered marginal costs of abatement curves and made them more uniform across powerplants. The low price of permits and low trading volume are evidence that market approaches to pollution control can be more cost-effective than command and control regulations. The effect of public policies and technological changes on the allowance market are usefully examined in the context of an ideal market, in which the equilibrium price of allowances equals the marginal cost of abatement of individual powerplants. Using recent data from Coggins and Swinton (1996), we are able to explain the current price of permits with some accuracy.     

Combination calculi for uncertainty reasoning: representing uncertainty using distributions

There are many different methods for incorporating notions of uncertainty in evidential reasoning. A common component to these methods is the use of additional values, other than conditional probabilities, to assert current degrees of belief and certainties in propositions. Beginning with the viewpoint that these values can be associated with statistics of multiple opinions in an evidential reasoning system, we categorize the choices that are available in updating and tracking these multiple opinions. In this way, we develop a matrix of different uncertainty calculi, some of which are standard, and others are new. The main contribution is to formalize a framework under which different methods for reasoning with uncertainty can be evaluated. As examples, we see that both the “Kalman filtering” approach and the “Dempster–Shafer” approach to reasoning with uncertainty can be interpreted within this framework of representing uncertainty by the statistics of multiple opinions. This revised version was published online in June 2006 with corrections to the Cover Date.     

Polarization control in a vertical cavity surface emitting laser submitted to optical feedback

We study experimentally and theoretically two polarization effects in a vertical cavity surface emitting laser submitted to optical feedback. In a first experiment, we obtain flips between two linearly polarized laser modes up to a frequency of 50 MHz using an external cavity with a polarizer. In a second experiment, polarization self modulation is demonstrated up to a frequency of 2.6 GHz, using a quarter wave plate instead. Numerical calculations, based on a four levels model for the active medium, show a good agreement with the experiments.     

Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines

Certain bacterial immunostimulatory (i.s.) DNA sequences containing unmethylated CpG motifs stimulate antigen-presenting cells (APC) to express a full complement of costimulatory molecules and to produce cytokines including interleukin (IL)-12 and tumor necrosis factor (TNF)-alpha. While IL-12 is key to their T helper cell (Th)1-promoting adjuvant activity, secretion of toxic levels of TNF-alpha is harmful in that it promotes toxic shock. Given the beneficial as well as harmful consequences of i.s. DNA, we investigated the possibility of identifying DNA sequences, i.e. CpG oligodeoxynucleotides (ODN) which differentially activate IL-12 versus TNF-alpha cytokine production in APC. Here, we describe an i.s. DNA sequence with these characteristics. While its potential to induce IL-12 is preserved, its ability to trigger TNF-alpha release is strongly curtailed both in vitro and in vivo. I.s. DNA could be segregated into lethal and non-lethal in a mouse toxic shock model. The non-toxic i.s. DNA was useful as an adjuvant, thus allowing cytotoxic T cell responses to the soluble protein ovalbumin and conferring a resistant Th 1 phenotype to BALB/c mice lethally infected with Leishmania major. This i.s. CpG motif may thus be prototypic for a useful immunostimulating DNA sequence that lacks harmful side effects.     

Assessing students' plans for college.

Based on a contemporary cognitive-psychoanalytic theory (control-mastery theory; J. Weiss, H. Sampson, & Mount Zion Psychotherapy Research Group, 1986), this study proposed that college students have plans for college that consist of conscious and unconscious goals and obstructions to be overcome in meeting those goals. The construct of unconscious guilt was used to mediate the dual goals of autonomy and attachment. The idiographic plan-formulation method was adapted to derive plans for 12 sophomore women. Acceptable interjudge reliabilities and criterion validity were demonstrated, and several themes in the goals and obstructions were illustrated. Students worried more about mothers than about fathers, particularly when they perceived the mother as weak or needy. The potential of the method for generating inferences about unconscious process for normative development is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Neural networks,rational functions,and realization theory

The problem of parametrizing single hidden layer scalar neural networks with continuous activation functions is investigated. A connection is drawn between realization theory for linear dynamical systems, rational functions, and neural networks that appears to be new. A result of this connection is a general parametrization of such neural networks in terms of strictly proper rational functions. Some existence and uniqueness results are derived. Jordan decompositions are developed, which show how the general form can be expressed in terms of a sum of canonical second order sections. The parametrization may be useful for studying learning algorithms.This work was supported by the Australian Research Council, the Australian Telecommunications and Electronics Research Board, and the Boeing Commencai Aircraft Company (thanks to John Moore).