肠靶向海藻酸钙基微胶囊的制备及控释性能研究

利用毛细管共挤出技术结合静电吸附和仿生硅化的方法，制备了海藻酸钙-壳聚糖/精蛋白/二氧化硅(ACPSi)复合微胶囊。ACPSi复合微胶囊的平均粒径约3.18 mm，单分散性好，囊壁最外层的二氧化硅层可抑制其在肠液pH环境中的溶胀，增强囊的机械稳定性。将羟丙甲基纤维素邻苯二甲酸酯(HPMCP)肠溶微球作为释药“微阀门”，嵌入囊壁可以更好地控制微胶囊的释药行为。以吲哚美辛为模型药物，当药物浓度为22.5 mg/ml时，ACPSi载药微胶囊在pH 2.5模拟胃液中3 h时累计释药率仅为0.33%，而转移至pH 6.8模拟肠液中19 h时累计释药率为77.78%；囊壁嵌入HPMCP微球后，22 h时累计释药率可提高约4%。因此，该复合微胶囊具有良好的肠靶向作用和控释特性，作为口服肠靶向缓控释制剂具有良好的应用前景。     

Hydrogen Production from Catalytic Steam Reforming of Bio-Oils: A Critical Review

In the future, hydrogen will be an important energy carrier and industrial raw material. Catalytic steam reforming of bio-oils is a promising and economically viable technology for hydrogen production. However, during the reforming process, the catalysts are rapidly deactivated due to coke formation and sintering. Thus, maintaining the activity and stability of catalysts is the key issue in this process. Optimized operation conditions could extend the catalyst lifetime by affecting the coke morphology or promoting coke gasification. This article summarizes the recent developments in the field of catalytic steam reforming of bio-oils, focusing on the operation conditions, the properties of the catalysts, and the effects of the catalyst supports. The expected insights into the catalytic steam reforming of bio-oils will provide further guidance for hydrogen production from bio-oils.     

无人机在输电线路巡检中的多种应用

无人机技术目前的快速发展使得我们国家输电线路自身的巡检能力得到了持续的提升,基于此本文在对无人机技术给予认识的情况下,在了解了输电线路巡检过程中的使用优势之后,还总结了无人机技术在当前我国线路巡检过程中的应用路径以及应用方法;之后使用案例分析的方式分析了无人机技术在当前输电线路巡检过程中的应用方法。     

关于新疆热电厂职业危害分析与讨论

对比不同热电厂企业工人接触职业危害因素情况,分析原因,为在建或已建热电厂提供职业危害因素预防措施,降低企业由于设计、施工或管理方面原因造成后期运行过程中职业危害接触超标情况的发生。根据我室历年对新疆地区热电厂职业危害因素检测结果与评价报告的比较,找出不同热电厂职业病危害因素的共性及异性,分析不同设备、工艺及管理方式不同所造成职业危害因素检测结果的差异及原因。建议优化厂区工艺及土建设计;优化设备选型及原料选择运用现代化的管理手段,加强职业卫生管理体系宣贯的有效运作。     

Blocked crystallization in capped ultrathin polymer films studied by molecular simulations

The crystallization of capped ultrathin polymer films is closely dependent on film thickness and interfacial interaction. Using dynamic Monte Carlo simulations, the crystallization behaviors of polymer films confined between two substrates were investigated. The crystallization rate of confined polymers is reduced with high interfacial interactions. Above a critical strength of interfacial interaction, polymer crystallization in the thin film is inhibited within the simulation time scales. An increase in film thickness leads to a rise in critical interfacial interaction. In thicker films, the chains have more space to change conformation to form crystal stems. In addition, there are fewer absorbed segments in confined chains for the thicker films, and thus the chains have stronger ability to adjust their conformation. Therefore an increase in film thickness can cause a reduction in the entropic barrier required for the formation of crystals and thus an increase in the critical interfacial interaction. © 2018 Society of Chemical Industry     

基于GFU和分层LSTM的组群行为识别研究方法

提出一种以"关键人物"为核心，使用门控融合单元（GFU，Gated Fusion Unit）进行特征融合的组群行为识别框架，旨在解决两个问题：①组群行为信息冗余，重点关注关键人物行为特征，忽略无关人员对组群行为的影响；②组群内部交互行为复杂，使用GFU有效融合以关键人物为核心的交互特征，再通过LSTM时序建模成为表征能力更强的组群特征.最终，通过softmax分类器进行组群行为类别分类.该算法在排球数据集上取得了86.7%的平均识别率.     

多晶硅锭中硬质点分析及控制研究

以多晶硅锭中硬质点为研究对象,通过实验研究和数值模拟的方法,对多晶硅锭中硬质点进行形貌和成分分析,并提出改善控制方法。研究结果表明硅锭中部的硬质点较细小,主要由SiC组成;硅锭头部的硬质点较粗大,主要由SiC和Si3N4组成,还有少量O的存在。进一步研究发现多晶硅定向凝固铸锭炉的热场结构对于多晶硅锭硬质点形成有直接影响,通过改进热场结构,优化晶体生长界面,显著减少了铸锭中硬质点的数量。     

工程造价市场化改革下定额的再认识与建议

随着工程造价市场化改革的深入推进,市场决定工程造价机制将逐步建立和完善,因计划经济体制得以广泛应用的定额需要在市场化机制下回归本质.本文梳理总结我国定额的发展脉络,分析定额的认识误区和存在问题,从建立基于动态定额的造价指标、发挥定额在施工企业管理中的作用等四个方面提出相关建议.     

Metal-polyphenol-network coated CaCO3 as pH-responsive nanocarriers to enable effective intratumoral penetration and reversal of multidrug resistance for augmented cancer treatments

Construction of multifunctional stimuli-responsive nanotherapeutics enabling improved intratumoral penetration of therapeutics and reversal of multiple-drug resistance (MDR) is potent to achieve effective cancer treatment. Herein, we report a general method to synthesize pH-dissociable calcium carbonate (CaCO₃) hollow nanoparticles with amorphous CaCO₃ as the template, gallic acid (GA) as the organic ligand, and ferrous ions as the metallic center via a one-pot coordination reaction. The obtained GA–Fe@CaCO₃ exhibits high loading efficiencies to both oxidized cisplatin prodrug and doxorubicin, yielding drug loaded GA–Fe@CaCO₃ nanotherapeutics featured in pH-responsive size shrinkage, drug release, and Fenton catalytic activity. Compared to nonresponsive GA–Fe@silica nanoparticles prepared with silica nanoparticles as the template, such GA–Fe@CaCO₃ confers significantly improved intratumoral penetration capacity. Moreover, both types of drug-loaded GA–Fe@CaCO₃ nanotherapeutics exhibit synergistic therapeutic efficacies to corresponding MDR cancer cells because of the GA–Fe mediated intracellular oxidative stress amplification that could reduce the efflux of engulfed drugs by impairing the mitochondrial-mediated production of adenosine triphosphate (ATP). As a result, it is found that the doxorubicin loaded GA–Fe@CaCO₃ exhibits superior therapeutic effect towards doxorubicin-resistant 4T1 breast tumors via combined chemodynamic and chemo-therapies. This work highlights the preparation of pH-dissociable CaCO₃-based nanotherapeutics to enable effective tumor penetration for enhanced treatment of drug-resistant tumors.