Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet

BACKGROUND: Reduced oxygen availability at high altitude is associated with increased neonatal and infant mortality. We hypothesized that native Tibetan infants, whose ancestors have inhabited the Himalayan Plateau for approximately 25,000 years, are better able to maintain adequate oxygenation at high altitude than Han infants, whose ancestors moved to Tibet from lowland areas of China after the Chinese military entered Tibet in 1951. METHODS: We compared arterial oxygen saturation, signs of hypoxemia, and other indexes of neonatal wellbeing at birth and during the first four months of life in 15 Tibetan infants and 15 Han infants at 3658 m above sea level in Lhasa, Tibet. The Han mothers had migrated from lowland China about two years previously. A pulse oximeter was placed on each infant's foot to provide measurements of arterial oxygen saturation distal to the ductus arteriosus. RESULTS: The two groups had similar gestational ages (about 38.9 weeks) and Apgar scores. The Han infants had lower birth weights (2773 +/- 92 g) than the Tibetan infants (3067 +/- 107 g), higher concentrations of cord-blood hemoglobin (18.6 +/- 0.8 g per deciliter, vs. 16.7 +/- 0.4 in the Tibetans), and higher hematocrit values (58.5 +/- 2.4 percent, vs. 51.4 +/- 1.2 percent in the Tibetans). In both groups, arterial oxygen saturation was highest in the first two days after birth and was lower when the infants were asleep than when they were awake. Oxygen saturation values were lower in the Han than in the Tibetan infants at all times and under all conditions during all activities. The values declined in the Han infants from 92 +/- 3 percent while they were awake and 90 +/- 5 percent during quiet sleep at birth to 85 +/- 4 percent while awake and 76 +/- 5 percent during quiet sleep at four months of age. In the Tibetan infants, oxygen saturation values averaged 94 +/- 2 percent while they were awake and 94 +/- 3 percent during quiet sleep at birth and 88 +/- 2 percent while awake and 86 +/- 5 percent during quiet sleep at four months. Han infants had clinical signs of hypoxemia--such as cyanosis during sleep and while feeding--more frequently than Tibetans. CONCLUSIONS: In Lhasa, Tibet, we found that Tibetan newborns had higher arterial oxygen saturation at birth and during the first four months of life than Han newborns. Genetic adaptations may permit adequate oxygenation and confer resistance to the syndrome of pulmonary hypertension and right-heart failure (subacute infantile mountain sickness).     

布正伟新作八人谈——思想与创作共舞：读《创作视界论》谈布正伟先生

作为在高等院校设计院工作的一名建筑师．除埋头设计外，我对理论问题有相当的偏好．这种偏好又带有很强的实用主义色彩。尤其对那些既有精妙设计．又有睿智思想的建筑师很是崇拜．这当然包括设计作品和理论专著文章。而且每每喜欢将作品与理论文章对照着来读，字里行间仿佛看到一个个作品跃然纸上．而实际工程又仿佛在叙述着作者的思想．这种读法令我了解了许多建筑师。然而不难发现．     

Cryptosystems using Linear Groups

Several suggestions are presented for developing cryptosystems, both classical and public key, using a combination of combinatorial group theory and linear groups. In particular, the Reidemeister-Schreier rewriting process is used as a one way function. These suggestions raise further questions concerning both implementation and security that are being explored in the thesis of Xu [16].     

用最小二乘法恢复逐行倒相副载波

介绍ＰＡＬ制彩色全电视信号中色同步信号编码原理及恢复逐行倒相副载波的过程中，两种计算色同步信号相位角的方法。并且在实验的基础上得出：最小二乘法在ＰＡＬ制电视信号的副载波相位角计算中不仅可以满足精度要求，而且简便灵活。     

Optic flow field segmentation and motion estimation using a robustgenetic partitioning algorithm

Optic flow motion analysis represents an important family of visual information processing techniques in computer vision. Segmenting an optic flow field into coherent motion groups and estimating each underlying motion is a very challenging task when the optic flow field is projected from a scene of several independently moving objects. The problem is further complicated if the optic flow data are noisy and partially incorrect. In this paper, the authors present a novel framework for determining such optic flow fields by combining the conventional robust estimation with a modified genetic algorithm. The baseline model used in the development is a linear optic flow motion algorithm due to its computational simplicity. The statistical properties of the generalized linear regression (GLR) model are thoroughly explored and the sensitivity of the motion estimates toward data noise is quantitatively established. Conventional robust estimators are then incorporated into the linear regression model to suppress a small percentage of gross data errors or outliers. However, segmenting an optic flow field consisting of a large portion of incorrect data or multiple motion groups requires a very high robustness that is unattainable by the conventional robust estimators. To solve this problem, the authors propose a genetic partitioning algorithm that elegantly combines the robust estimation with the genetic algorithm by a bridging genetic operator called self-adaptation     

Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas

Carcinoma in ulcerative colitis (UC) develops from dysplastic precursor lesions, which include flat dysplasia (FD) and polypoid dysplasias (PD). PD may present as single or multiple polypoid structures or as plaque-like lesions that, independent of histological grade, are an indication for colectomy. PDs are histologically similar to adenomas and may not be readily distinguished by light microscopy. It is not known whether FD and PD are different entities, or whether they represent etiologically similar lesions with different morphological expression. We microdissected 25 cases of UC with PD and 19 samples of FD with surrounding chronic colitis (CC) in UC. Loss of heterozygosity (LOH) at the von Hippel Lindau (vHL) gene locus and the putative tumor suppressor genes APC, INK4A (9p16), and p53 was studied. LOH of the vHL gene, INK4A (9p16), and APC was also studied in 11 sporadic adenomas of the colon. LOH at the vHL locus was present in 50% of the samples of PD and in 12% of the samples of FD. LOH was seen in CC close to PD and FD in 26% and 12% of cases, respectively. No adenoma showed LOH of the vHL gene markers studied. LOH in p53 was seen in PD in 16% cases and in FD in 42% cases and in CC close to PD and FD in 0% and 14% cases, respectively. LOH patterns between PD and FD of the markers for APC and 9p16 were not different. LOH in APC was seen in two of five cases of adenoma. We conclude that PD and FD share genetic alterations in APC and 9p16 genes. More frequent involvement of the VHL gene in PD and surrounding CC and involvement of p53 in HGD and CC in FD may represent genetic differences between the development of PD and FD and may be the cause of the different morphology. The infrequency of LOH at the vHL locus in adenomas versus PD may serve as a discriminator between adenomas and PD in diagnostically problematic cases.     

SiH4＋CH4激光等离子体动力学时空特性

采用时间，空间分辨的等离子体光辐射诊断技术，研究了脉冲ＴＥＡＣＯ２激光诱发ＳｉＨ４＋ＣＨ４击穿产生的等离子体膨胀过程，得到不同空间位置，不同实验条件下等离子体发光的时间特性，证明了ＳｉＨ４＋ＣＨ４气体击穿产生爆燃波而后诱发激波是等离子体中基本宏观动力学过程，并在实验上分析了激波对等离体内化学反应的影响，为激光等离子体合成ＳｉＣ粉末微观反应动力学过程的研究提供了参考数据。     

半导体光开关工作电流和速率的理论分析

本文从载流子连续性方程出发，采用半导体双异质结概念，从理论上推出了计算半导体光波导开关工作电流和速率的理论公式，为器件选取工作电流和提高开关速率提供了理论依据．     

ROSA:资源敏感的高性能Web容器体系结构

现有的Web容器多采用线程池体系结构,而Web容器所支撑的动态Web组件在执行过程中可能需要获取多种共享资源,由共享资源并发量限制导致的线程阻塞可能会严重影响性能。提出了一种资源敏感的Web容器体系结构ROSA(resource-oriented staged architecture)。当某些共享资源达到饱和时,若Web容器接到对需要这些资源的Web组件的请求,ROSA会暂缓为这些请求提供服务以减少线程阻塞。基于排队Petri网,建立了ROSA结构和线程池结构的性能模型,通过模型仿真和负载实验验证了ROSA体系结构的性能优势。     

基于数据预取的多核处理器末级缓存优化方法

末级缓存的性能已成为影响多核处理器整体性能的关键因素.基于多核处理器在处理并行程序时各处理器核访存行为的相似性,提出一种降低访存缺失率的数据预取方法.首先记录各处理器核的访存缺失历史;然后通过分析历史信息预测各处理器核之间末级缓存缺失的关联关系,采用数据预取的方式,在处理器核出现读缺失之前为其末级缓存提供数据块.实验结果表明,对于4核和16核处理器系统,该方法可以分别降低末级缓存缺失率9.8％和18.4％,提高性能4.0％与12.4％.