Deliberately Losing Control of C−H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism

Combined photochemical arylation, “nuisance effect” (S_NAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein–ligand structure determination. Reactions were deliberately allowed to run “out of control” in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with S_NAr processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.     

Magnetic and Electrical Properties of Glass and Glass-Ceramics Based on Weathered Basalt

Silicon - A total of six glass batches (WB100-WB50) based primarily on weathered basalt with successive addition of bypass cement dust (with the weight content 0–50%) were melted at...     

Heat Propagation in Deformable Polycrystalline Metals with Grain-Size Variation

Russian Engineering Research - Attention focuses on the heat propagation in metal polycrystals where the grain or subgrain size affects the strengthening—as a result of surface plastic...