ZrO2陶瓷膜结构研究

以氧氯化锆为起始原料，通过溶胶－凝胶技术制备了无支撑体ＺｒＯ２陶瓷膜，ＤＴＡ－ＴＧ、ＸＲＤ、ＢＥＴ、ＳＥ等分析测试手段对陶瓷膜结构及其孔性能进行了表征，结果表明，ＺｒＯ２陶瘊膜具有高度的择优取向特征，膜烧结过程存在关ＺｒＯ２昌相转变，ＺｒＯ２陶瓷膜孔径〈５０ｎｍ，且呈双值分布，本言语亦基于实验分析对陶瓷膜的结构模型进行了初步探讨。     

添加微量锡对铜基摩擦材料性能的影响

研究了添加微量锡对铜基摩擦的摩擦性能的影响。结果表明，微量锡对摩擦系数无显著影响，但对磨损有显著影响，当锡含量为０．５０％时，摩擦材料及对偶材料的磨损都较小。     

重型血友病甲基因诊断新技术的研究及其应用

远用长距离ＤＮＡ扩增技术成功地检测出凝血八因子ＦⅧ基因倒位缺陷患者，并检出该倒位的女性携带者。     

双马来酰亚胺基体树脂的改性研究

本文报道用改性物B改善双马来酰亚胺/二胺预聚物溶解性的实验研究.结果表明,改性后的双马来酰亚胺/二胺基体树脂在低沸点、低毒性溶剂如丙酮中具有良好的溶解性,并且有足够的均相期,为湿法制作预浸料创造了有利条件.同时对树脂的固化反应、耐热稳定性及其复合材料在高温条件下(150℃、200℃)的层间剪切性能进行了研究.     

清水砼技术在民用建筑中的应用——浅谈建设项目如何应用新技术

本文通过介绍清水砼技术在民用建筑中的应用,对建设项目如何应用新技术进行探讨。     

在役生产装置安全评价存在的职业卫生问题

分析了在役生产装置安全评价存在的职业卫生问题,提出了如何做好重点生产装置职业病预防工作的建议。     

基于MSP430F413 MCU的IC卡煤气表的设计与实现

提出了以TI公司MSP430系列MCU为基础的IC卡煤气表的设计思想，给出了总体设计，硬件电路设计，软件流程设计及主要模块的编程框架，讨论了低功耗问题。同时，对IC卡煤气表设计中一些应注意的问题也进行了简要的阐述。     

构建本科院校质量保障体系

近年来，新建本科院校取得了快速发展。本文结合工作实际，就新建本科院校如何尽快完成角色转变，建立健全自身的人才培养质量保障体系进行了分析和研究。     

Mechanisms responsible for resistance of sublines derived from leukemia cell lines to an antitumor agent 9-beta-D-arabinofuranosyl-2-fluoroadenine

An agent 9-beta-D-arabinofuranosyl-2-fluoroadenine (2-F-Ara-A) is a main metabolite of fludarabine, a fluorinated purine analogue with antitumor activity in lymphoproliferative malignancies. In this study, the mechanism responsible for the resistance of cancer cells to fludarabine was examined using the 2-F-Ara-A-resistant sublines JOK-1/F-Ara-A and L1210/F-Ara-A from a human hairy leukemic cell line (JOK-1) and a mouse leukemic cell line (L1210) respectively, which were established by continuous treatment of the parental cell lines with 2-F-AraA. JOK-1/F-Ara-A and L1210/F-Ara-A cells were more than 55 and 29 times more resistant to 2-F-Ara-A than were their parent cell lines, and showed a high cross-resistance to 1-beta-D-arabinofuranosylcytosine but not to doxorubicin or vincristine. These resistant sublines intracellularly accumulated almost the same amount of 2-F-Ara-A as did their parent cell lines. However, the amount of 2-F-Ara-ATP, a cytotoxic metabolite of 2-F-Ara-A, decreased by 2.6% (JOK-1/F-Ara-A C3), 6% (L1210/F-Ara-A C1) and 3.7% (L1210/F-Ara-A C7) relative to the levels in the parent cell lines. Enzymatically, these resistant cells hardly activated deoxycytidine (dCyd) and 2-F-Ara-A. In addition, the abilities to phosphorylate deoxyadenosine and deoxyguanosine were also decreased in the resistant cells in comparison with the parent cells. These findings suggest that the deficiency in activity of dCyd kinase may contribute to the resistance of 2-F-Ara-A.