Delivering nanotechnology to the healthcare, IT and environmental sectors — A perspective from the ‘London centre for nanotechnology’

Nanotechnology research is booming worldwide, having an impact on multiple sectors and with a general belief that medical and biological applications will form the greatest area of expansion over the next decade, driven by an attempt to bring radical solutions to areas of unmet medical need. What is true in the USA is also being fulfilled in Europe, though generally at a significantly lower investment level, even for ’large’ capital infrastructure and interdisciplinary centres. Against this, the UK and its European partners are following the maxim ’small is beautiful’ and are attempting to identify and grow academic research and commercial businesses in areas that traditional nanotechnology developments out of engineering or physics find challenging. Thus, University College London and Imperial College, in a major joint project linked to other centres of excellence both in the UK and in the rest of Europe, are building upon their internationally competitive medical and hard-matter research activities to focus on and develop nanotechnology as a major sector of research activity. The two universities together form one of the largest centres of biomedical research outside the USA. A novel approach to commercialisation has been taken, exemplified by the establishment with government and private equity funds of a ‘Bionanotechnology Centre’ — this will act as a portal for UK industry to access specialist skills to solve issues relating to developing nanotechnology-based medical applications, for example, for environmental screening, diagnostics and therapy. This paper reviews our academic and business strategy with examples from our current research portfolio, biased towards medicine as the London Centre for Nanotechnology’s most rapidly growing area.     

Acidogenic fermentation of blended food‐waste in combination with primary sludge for the production of volatile fatty acids

The performance of a laboratory‐scale anaerobic acidogenic fermenter fed with a mixture of blended kitchen food‐waste and primary sludge from a sewage treatment plant was investigated for the production of volatile fatty acids (VFA). The operating variables for acidogenic fermentation were kitchen food‐waste content (10 and 25 wt %), hydraulic retention time (HRT: 1, 3 and 5 days), temperature (ambient: 18 ± 2 °C, and mesophilic: 35 ± 2 °C) and pH (varied from 5.2 to 6.7). The experimental results indicated that effluent VFA concentrations and VFA production rates were higher at ambient temperature than at mesophilic conditions. The net amount of VFA with 10 wt % food‐waste increased up to 920 mg dm^?3 with an increase of HRT, but contrasting results (a decrease of 2610 mg dm^?3) were found due to the conversion of VFA into biogas in the case of 25 wt % food‐waste, which increased significantly at HRT of 3–5 days. In terms of biogas composition (CO₂ and CH₄), the organic matter was converted into CO₂ through the oxidative pathway by facultative species at low temperature while mesophilic temperature and optimum pH (6.3–7.8) played a pivotal role in increasing rate of conversion of VFA into biogas by methanogenesis. Rates of VFA production and their conversion are dependent on the food‐waste content in the mixture. Yet, the higher concentration of food‐waste (25% compared with 10%) did not produce VFA proportionally due to the increased rate of conversion of VFA into gaseous products. The maximum VFA production rate (0.318 g VFA_produced g^?1 VS_fed day^?1) was achieved in the 10 wt % food‐waste at ambient temperature and at a 5‐day HRT. Copyright © 2005 Society of Chemical Industry     

The effect of OPWF filler on impact strength of glass-fiber reinforced epoxy composite

In the present study, oil palm wood flour (OPWF) particles with less than 250 μm sizes have been used as filler materials in the woven-glass-fiber reinforced epoxy composite. The hybrid composites were fabricated using a hand lay-up method and cured at room temperature under a compressive load of 196 N (20 kg). The OPWF of 2.5 to 10 parts per hundred (pph) by weight was used to evaluate its effect on impact strength of the hybrid composites at a range of temperature from −50 to 50 °C. The impact strength, evaluated using V-notch Charpy method, showed reduction with increasing filler content up to 5 pph and then the strength increment in those composites containing more than 5 pph OPWF. More severe damages were found in specimens with higher filler contents resulting higher energy absorption during impact. The composites with a large amount of OPWF particles deflected crack propagation paths or created obstacles at the crack tips and increased toughness of the composites. The impact strength was found to decrease when the samples fractured at subzero temperatures and this happened because of the reduction of the matrix ductility at lower temperatures.     

Electrical Insulation Characteristics of Silicone and EPDM Polymeric Blends. I

The typical parts of a polymeric insulator are core, metal end fittings and polymeric housing material. The housing is intended to protect the fibre glass rod from the environment and electrical surface discharges. Since the housing materials are made of organic polymeric material, its insulation characteristics need to be studied. Amongst the many different polymers available, this work focuses on silicone rubber and ethylene propylene diene monomer (EPDM). Blends of EPDM and silicone rubber are prepared in a two roll mixing mill. Dicumyl peroxide is used as vulcanizing agent. The blends consisting of various proportions of component polymers are prepared, compression moulded into sheets, and post cured. The blends are tested for their insulation characteristics as per IEC and ASTM standards. Volume and surface resistivity, dielectric strength, dielectric constant, tan delta, tracking resistance, arc resistance, comparative tracking index, tensile strength, and percentage elongation at break of the blends are studied and discussed. The test results show that the increasing proportion of silicone enhances the electrical insulation properties whereas increasing weight percentage of EPDM improves the mechanical strength of the blends.     

Multidimensional vector radix FHT algorithms

In this paper, efficient multidimensional (M-D) vector radix (VR) decimation-in-frequency and decimation-in-time fast Hartley transform (FHT) algorithms are derived for computing the discrete Hartley transform (DHT) of any dimension using an appropriate index mapping and the Kronecker product. The proposed algorithms are more effective and highly suitable for hardware and software implementations compared to all existing M-D FHT algorithms that are derived for the computation of the DHT of any dimension. The butterflies of the proposed algorithms are based on simple closed-form expressions that allow easy implementations of these algorithms for any dimension. In addition, the proposed algorithms possess properties such as high regularity, simplicity and in-place computation that are highly desirable for software and hardware implementations, especially for the M-D applications. A close relationship between the M-D VR complex-valued fast Fourier transform algorithms and the proposed M-D VR FHT algorithms is established. This type of relationship is of great significance for software and hardware implementations of the algorithms, since it is shown that because of this relationship and the fact that the DHT is an alternative to the discrete Fourier transform (DFT) for real data, a single module with a little or no modification can be used to carry out the forward and inverse M-D DFTs for real- or complex-valued data and M-D DHTs. Thus, the same module (with a little or no modification) can be used to cover all domains of applications that involve the DFTs or DHTs.     

Lowpass and bandpass transadmittance filter using operational amplifier pole

A new topology simultaneously implementing lowpass (LP) and bandpass (BP) transadmittance filtering signals using a single operational amplifier (OA), one capacitor, and two resistors is presented. The input impedance is very high which is essential for cascading without employment of buffers. The circuit uses absolute minimum number of active and passive components. The filter employs pole-model of OA and as such has acquired suitability for extended frequency operation. The circuit permits separate adjustment of natural frequency (ω₀) and quality factor (Q) in an orthogonal manner. The circuit has low sensitivity figures unlike the reported single amplifier biquads. The PSPICE simulation results are included.     

An analytical method for the calculation of static characteristicsof linear step motors for control rod drives in nuclear reactors

An analytical method for calculating static characteristics of linear dc step motors (LSM) is described. These multiphase passive-armature motors are now being developed for control rod drives (CRD) in large nuclear reactors. The static characteristics of such LSM is defined by the variation of electromagnetic force with armature displacement and it determines motor performance in its standing and dynamic modes of operation. The proposed analytical technique for calculating this characteristic is based on the permeance analysis method applied to phase magnetic circuits of LSM. Reluctances of various parts of phase magnetic circuit is calculated analytically by assuming probable flux paths and by taking into account complex nature of magnetic field distribution in it. For given armature positions stator and armature iron saturations are taken into account by an efficient iterative algorithm which gives fast convergence. The method is validated by comparing theoretical results with experimental ones which shows satisfactory agreement for small stator currents and weak iron saturation     

Binding of the Epstein-Barr virus to human platelets causes the release of transforming growth factor-beta

Human platelets bear on their surface complement receptor type II (CR2), which is also the receptor for the EBV. Although the cross-linking of these receptors causes activation and aggregation of platelets, no immunologic consequence of the potential binding of EBV to these receptors on human platelets has ever been described. We report here that binding of EBV to human platelets causes the release of TGF-beta from the latter. Both infectious and UV-inactivated noninfectious viral particles can mediate this release. Anti-CR2 mAb OKB7, which blocks the binding of EBV to CR2, also blocks the EBV-mediated release of TGF-beta. Furthermore, platelets recovered from the initial incubation no longer release TGF-beta upon subsequent incubation with EBV. Since TGF-beta is a potent immunosuppressive agent, its release from platelets upon binding of EBV may play a role in the pathogenesis of EBV-associated diseases.     

Polymorphism of bacteriophage T7

For viruses made of nucleic acid and protein, the structure of the protein outer shell has, in the past, been found to be uniquely determined by the viral genome. However, here, non-denaturing agarose gel electrophoresis of bacteriophage T7 reveals two states of the mature T7 capsid; the conditions of growth are found to alter the population by T7 of these two electrophoretically defined states. Both states have been previously observed for a genetically altered T7 and they are observed here for wild-type T7. The average electrical surface charge density of a bacteriophage particle (delta) determines its state; the delta of particles in both states is negative. For a given condition of growth, the population of these two states is influenced by the extent to which the major T7 outer shell protein, p10A, is accompanied by its minor readthrough variant, p10B. Comparison of the two electrophoretic states reveals the following. (1) No difference in radius is present in the outer shell (+/-2%). (2) As the pH of electrophoresis is either increased or decreased from neutrality, the state becomes more highly populated for which delta is greater in magnitude (state 1). By changing the pH, some T7 particles are made to change state. (3) Particles in state 1 adsorb less quickly to host cells than do the particles in the alternative state (state 2). This latter observation suggests the hypothesis that state 1 evolved to reduce the probability of re-initiating an infection when conditions are not favorable for growth. This hypothesis is supported by the observation that, as conditions of growth become apparently more unfavorable, progeny increasingly populate state 1.