Comparison of two quantitative proton density mapping methods in multiple sclerosis

Objective

Proton density (PD) mapping requires correction for the receive profile (RP), which is frequently performed via bias-field correction. An alternative RP-mapping method utilizes a comparison of uncorrected PD-maps and a value ρ(T1) directly derived from T1-maps via the Fatouros equation. This may be problematic in multiple sclerosis (MS), if respective parameters are only valid for healthy brain tissue. We aimed to investigate whether the alternative method yields correct PD values in MS patients.

Materials/methods

PD mapping was performed on 27 patients with relapsing-remitting MS and 27 healthy controls, utilizing both methods, yielding reference PD values (PD_ref, bias-field method) and PD_alt (alternative method).

Results

PD_alt-values closely matched PD_ref, both for patients and controls. In contrast, ρ(T1) differed by up to 3 % from PD_ref, and the voxel-wise correlation between PD_ref and ρ(T1) was reduced in a patient subgroup with a higher degree of disability. Still, discrepancies between ρ(T1) and PD_ref were almost identical across different tissue types, thus translating into a scaling factor, which cancelled out during normalization to 100 % in CSF, yielding a good agreement between PD_alt and PD_ref.

Conclusion

RP correction utilizing the auxiliary parameter ρ(T1) derived via the Fatouros equation provides accurate PD results in MS patients, in spite of discrepancies between ρ(T1) and actual PD values.

     

Endogenous Nitric-Oxide Synthase Inhibitor ADMA after Acute Brain Injury

Previous results on nitric oxide (NO) metabolism after traumatic brain injury (TBI) show variations in NO availability and controversial effects of exogenous nitric oxide synthase (NOS)-inhibitors. Furthermore, elevated levels of the endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) were reported in cerebro-spinal fluid (CSF) after traumatic subarachnoid hemorrhage (SAH). Therefore, we examined whether ADMA and the enzymes involved in NO- and ADMA-metabolism are expressed in brain tissue after TBI and if time-dependent changes occur. TBI was induced by controlled cortical impact injury (CCII) and neurological performance was monitored. Expression of NOS, ADMA, dimethylarginine dimethylaminohydrolases (DDAH) and protein-arginine methyltransferase 1 (PRMT1) was determined by immunostaining in different brain regions and at various time-points after CCII. ADMA and PRMT1 expression decreased in all animals after TBI compared to the control group, while DDAH1 and DDAH2 expression increased in comparison to controls. Furthermore, perilesionally ADMA is positively correlated with neuroscore performance, while DDAH1 and DDAH2 are negatively correlated. ADMA and its metabolizing enzymes show significant temporal changes after TBI and may be new targets in TBI treatment.     

‘Must our cities remain ugly?’ – America's urban crisis and the European city: transatlantic perspectives on urban development, 1945–1970

This article explores the changing modes and mechanisms of the transatlantic dialogue between urban planners from the perspective of US urbanists. During the early post-war period, this dialogue intensified quickly. US planners were involved in their country's broad efforts to provide assistance to and build strong political ties with Western European nations. Accordingly, they assumed the role of tutors vis-à-vis their European peers. Due to urban America's apparent flaws and the success of European planning projects, however, their interest in Europe broadened considerably during the 1950s. Initially, the initiative of individuals remained crucial for the flow of planning information from Europe to the USA, and European immigrants and émigrés helped facilitate transatlantic transfers. Looking at Europe, American planners sought to address the shortcomings of the domestic practice of planning as they perceived them. Europe served as an argumentative tool for US experts who were eager to change the socio-political framework that limited their impact on urban development in their home country. Information about European planning was transmitted through a diverse set of channels and the biographies of many of the experts involved with transatlantic exchange remind us of the complex international planning networks that existed throughout the twentieth century. American planners' interest in Europe remained biased towards specific regions and topics. Nevertheless, US planners negotiated the way in which they brought their limited influence to bear on American urban environments in a transnational context. The framework that supported their integration into international planning discussions became increasingly institutionalized towards the end of the research period.     

Thermoelectric Coolers with Sintered Silver Interconnects

The fabrication and performance of a sintered Peltier cooler (SPC) based on bismuth telluride with sintered silver interconnects are described. Miniature SPC modules with a footprint of 20 mm² were assembled using pick-and-place pressure-assisted silver sintering at low pressure (5.5 N/mm²) and moderate temperature (250°C to 270°C). A modified flip-chip bonder combined with screen/stencil printing for paste transfer was used for the pick-and-place process, enabling high positioning accuracy, easy handling of the tiny bismuth telluride pellets, and immediate visual process control. A specific contact resistance of (1.4 ± 0.1) × 10^?5 Ω cm² was found, which is in the range of values reported for high-temperature solder interconnects of bismuth telluride pellets. The realized SPCs were evaluated from room temperature to 300°C, considerably outperforming the operating temperature range of standard commercial Peltier coolers. Temperature cycling capability was investigated from 100°C to 235°C over more than 200 h, i.e., 850 cycles, during which no degradation of module resistance or cooling performance occurred.     

Analysis of Radio Resource Allocation in LTE Uplink

Long term evolution (LTE) uses orthogonal frequency division multiple access (OFDMA) and single carrier frequency division multiple access (SC-FDMA) as the downlink and uplink transmission schemes respectively. The Quality of Service (QoS) provision to users is one of the key objectives of the wireless network operators. This paper analyses an uplink LTE radio scheduler, called bandwidth and QoS aware (BQA) scheduler and evaluates its QoS performance. The BQA uplink scheduler is designed to provide efficient and fair allocation of the radio resources to users according to: the QoS of various traffic classes and the instantaneous channel conditions. The scheduler functionality is divided into time domain packet scheduling (TDPS) and frequency domain packet scheduling (FDPS). In this paper, an innovative feature, that is user QoS provisioning with dynamic QoS weights, is employed for the BQA scheduler along with multi-bearer users support. The QoS performance of the BQA scheduler is analyzed in several simulation scenarios using heterogeneous traffic environment. The results show that the BQA scheduler guarantees provision of QoS to users.     

Sicherheit und rechtliche Herausforderungen in Bezug auf Cloud Computing und Kritische Infrastruktur-IT

The prevalence of machine-to-machine (M2M) will continue to increase because of the connection and interlinking of services in the domain of critical infrastructures (e.g. “smart grids”, traffic management or surveillance systems). This is leading to a constant rise of required computational and storage resources. As field systems typically offer only limited computing and storage capabilities and as many applications require a global view to integrated data from various devices, a natural location to store data and perform analysis tasks is in the Cloud, where an abundance of flexible resources can be used. However, this results in a number of security and privacy challenges in combination with some legal and technical considerations that need to be addressed. In this paper, we will investigate and categorize the above challenges associated with using the Cloud in a critical infrastructure and M2M context.     

Transient liquid phase bonding of HfC-based ceramics

Transient liquid phase (TLP) bonding enables joining at lower temperatures than traditional bonding techniques and preserves the potential for high-temperature applications, making it particularly attractive for joining ultra-high-temperature ceramics (UHTCs) such as carbides and borides. The feasibility of a TLP joint between “pure” carbides has been recently demonstrated. The present study examines the interactions that occur between undoped HfC or MoSi₂-doped HfC and a Ni/Nb/Ni multilayer interlayer during TLP bonding. Bonding is performed at 1400 °C for 30 min in a high-vacuum furnace. SEM–EDS characterization shows that the reaction layer formed at the interlayer/ceramic interface contains mixed carbides and depending upon the ceramic, Ni–Nb–Hf, or Ni–Nb–Hf–Si, or Ni–Nb–Si alloys. Nanoindentation tests traversing the reaction layer between the bulk ceramic and Nb foil midplane also show a clear transition zone across which the indentation modulus and hardness vary. Crack-free joints have been obtained with undoped HfC. The addition of 5 vol% MoSi₂ introduces small (<5 μm long) isolated cracks within the reaction layer, whereas with 15 vol% MoSi₂ added, cracking was pervasive within the reaction layer. When the reaction layer exceeds a critical thickness, as in the case of the bond obtained with HfC doped with 15 vol% MoSi₂, residual stresses become sufficiently large to cause extensive cracking and bond failure. The results suggest a need to characterize and balance the positive role of additives on sintering with the potentially deleterious role they may have on joining.