Compensation paradox: the influence of monetary rewards on user behaviour

Many e-commerce companies collect users’ personal data for marketing purposes despite privacy concerns. Information-collecting companies often offer a monetary reward to users to alleviate privacy concerns and ease the collection of personal information. This study focused on the negative effects of monetary rewards on both information privacy concerns (IPC) and information disclosure. A survey approach was used to collect data and 370 final responses were analysed using a two-way analysis of variance and a binomial logistic regression model. The results show that monetary rewards increase IPC when an information-collecting company requires sensitive information. Additional results indicate that building trust is a more effective way of collecting personal data. This study identifies how organisations can best execute information-collection activities and contributes additional insights for academia and practitioners.     

A quarter century of wine pigment discovery

The red grape berry pigments, anthocyanins, were characterized in the early 20th century, but investigations of wine pigments were stymied during that era. The question of their identity was a major challenge for wine chemists. A number of techniques showed that the pigments were polymeric in nature. Some structures were postulated by mid-century based on reactions between anthocyanins and condensed tannin, and later postulated wine pigments were observed in model reactions. Some related compounds were then observed in wine. By the end of the 20th century, the ionization of non-volatiles for mass spectrometry opened the door to these compounds. In addition, a new class of compounds was observed, the pyranoanthocyanins, a product of fermentation and aging metabolites with anthocyanins. These compounds possess the pigment stability to SO₂ and pH change that is characteristic of aged red wine. Aging experiments show a dynamic situation with shifts in the population of pigment classes over time. The very large number of diverse pigments explains why it has been so difficult to answer the century-old question of the structure of wine pigments. Our current understanding is founded on the use of mass spectral analysis using electrospray and related ionization techniques over the last 25 years. Future progress will rely on more sophisticated analysis of this very complex mixture of substances. © 2019 Society of Chemical Industry     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

Gonadal steroids have paradoxical effects on brain oxytocin receptors

Specific brain receptors for oxytocin have been described in several mammalian species. The distribution of these receptors differs greatly across species and in the rat, receptor binding in specific brain regions appears to depend upon gonadal steroids. This study used in vitro receptor autoradiography to examine the effects of testosterone on oxytocin receptor binding in the mouse forebrain. Three groups of male mice were compared: castrates treated with blank capsules, castrates treated with testosterone filled capsules, and intact males. Irrespective of steroid treatment, the distribution of oxytocin receptors in mouse forebrain differed markedly from patterns previously described in the rat. In addition to these species differences in receptor distribution, testosterone had effects in the mouse which differed from the induction of receptors previously reported in the rat. In the mouse ventromedial nucleus of the hypothalamus, binding in the untreated castrate males was approximately double that observed in either the intact or the testosterone-treated castrates. In other regions of the mouse brain, such as the intermediate zone of the lateral septum, binding to oxytocin receptors was increased with testosterone treatment. These results suggest that the brain oxytocin receptor varies across species not only in its distribution but also in its regional regulation by gonadal steroids. These apparently paradoxical changes in oxytocin receptor binding may result from either direct or indirect effects of gonadal steroids in mouse brain.     

Use of weibull statistics to quantify property variability in TiAl alloys

Tensile experiments have been performed on specimens of four different investment-cast TiAl-based alloys with variations in casting conditions. The average ductilities obtained in these experiments vary between approximately 0.8 to 2.0 pct plastic strain to failure in tension. By using the three-parameter form of the Weibull relation, with the 0.2 pct offset yield strength as the minimum failure strength, the resulting variability in the data can be quantified and is found to be similar for those alloys with similar microstructural scale (grain size). Large variations in lamellar volume fraction, segregation, and phase distribution have a minor influence on property variability, compared to changes in the scale of the grain structure caused by either variations in cooling rate during casting or the addition of grain refiners.     

A comparison of three approaches for predicting C4 species cover of northern mixed grass prairie

The C4 composition of Canadian mixed-grass communities is more sensitive to environmental change than other grasslands. Reliable methods of detecting such changes are necessary if these landscapes are to be properly managed. One approach is to use satellite remote sensing systems. Various studies have shown that the asynchronous seasonality of C3 and C4 species allows the relative abundance of each photosynthetic type to be estimated using temporal trajectory indices (TTIs) of sensor-derived normalized difference vegetation index (NDVI). In this study, we compared three approaches for predicting C4 species cover at Grasslands National Park (GNP) (Saskatchewan, Canada). TTIs related to Approach I were calculated from plots of NDVI vs. day-of-year (DOY). TTIs related to Approach II were calculated from plots of normalized cumulative NDVI vs. growing degree day (GDD). TTIs related to Approach III were calculated as ratios of early-season NDVI to late-season NDVI. Our analyses were conducted at two separate ecological scales. A within-community analysis used field-sampled data from upland grassland to compare techniques at sampling resolutions of 0.5, 2.5, 10, and 50 m. An across-community analysis compared techniques using a vegetation survey of the GNP region and TTIs calculated from Advanced Very High Resolution Radiometer (AVHRR) data (1 km). At both scales, TTIs related to the timing of specific phenological events were the best predictors of C4 species cover. While all techniques performed well in the within-community study, Approach III performed best. Here, the predictive ability of each approach was weak at a resolution of 0.5 m but stronger at 2.5, 10, and 50 m resolutions. We also found that the optimal sampling dates for Approach III fell within a certain GDD range. This is encouraging for the a priori selection of sample dates, which would make the need for full seasonal time series redundant. In the across-community analysis, the AVHRR-derived Approach II TTIs were better able to discriminate among grasslands of different C4 composition than any other technique (overall accuracy=74%). However, for some C4 cover classes, the predictive accuracy of this approach was low. While these results are encouraging for the use of spectral data in monitoring the C4 cover of northern prairie, various research issues remain. At the within-community level, these include (a) further attempts to define objective criteria for the a priori identification of sampling dates for Approach III, and (b) and the extension of such studies to other growing seasons and community types/grassland regions. At the across-community level, these include the expansion of such techniques to a larger geographical region that contains a wider range in C4 cover values and land use types (e.g. ungrazed vs. grazed grasslands).