Mechanische Eigenschaften des Stahles 8 CrMoNiNb910 in Abhängigkeit vom Gefügezustand

Zugversuche bei Raumtemperatur bis 600 °C und Zeitstandversuche bei 500 bis 600 °C bis rd. 75 000 h an zwei Schmelzen des Stahles 8 CrMoNiNb910 mit rd. 0,08% C, 0,3% Si, 0,7% Mn, 0,012% N, 0,005% Al, 2,34% Cr, 0,95% Mo, 0,8% Nb und 0,64% Ni im bainitischen und im ferritischen Gefügezustand. Einfluß eines Glühens bei überhöhten Temperaturen von 650 bis 800 °C auf die Eigenschaften im Zugversuch. Einfluß einer Auslagerung bei 500 bis 600 °C bis 30000 h Dauer mit und ohne gleichzeitige mechanische Beanspruchung auf die Eigenschaften im Zugversuch bei Auslagerungstemperatur und auf das Zähigkeitsverhalten im Kerbschlagbiegeversuch bei Raumtemperatur.     

Zum Legierungseinfluß auf die Umwandlungs- und Ausscheidungsvorgänge bei der Abkühlung warmfester Röhrenstähle nach dem Austenitisieren II. 12%ige Chromstähle

Untersuchung des Umwandlungs- und Ausscheidungsverhaltens von Stählen mit 12% Cr. Betrachtung des Anlaßverhaltens einschließlich des Restaustenitzerfalls nach Umwandlung in der Martensitstufe. Darstellung der Ergebnisse in Zeit-Temperatur-Umwandlung- und Phasenschaubildern.     

BTK and PI3K Inhibitors Reveal Synergistic Inhibitory Anti-Tumoral Effects in Canine Diffuse Large B-Cell Lymphoma Cells

Bruton’s tyrosine kinase (BTK) and phosphoinositide 3-kinase (PI3K) in the B-cell receptor (BCR) signaling pathway are considered potential therapeutic targets for the treatment of B-cell lymphomas, among which, diffuse large B-cell lymphoma (DLBCL) is the most common type. Herein, we comparatively evaluated the single and combined application of the BTK inhibitor ibrutinib and the selective PI3Kγ inhibitor AS-605240 in the canine DLBCL cell line CLBL-1. For further comparison, key findings were additionally analyzed in canine B-cell leukemia GL-1 and human DLBCL cell line SU-DHL-4. While ibrutinib alone induced significant anti-proliferative effects on all cell lines in a dose-dependent manner, AS-605240 only induced anti-proliferative effects at high concentrations. Interestingly, ibrutinib and AS-605240 acted synergistically, reducing cell proliferation and increasing apoptosis/necrosis in all cell lines and inducing morphological changes in CLBL-1. Moreover, the combined application of ibrutinib and AS-605240 reduced relative phosphorylation and, in some instances, the levels of the BTK, AKT, GSK3β, and ERK proteins. Comparative variant analysis of RNA-seq data among canine B- and T-lymphoid cell lines and primary B-cell lymphoma samples revealed potentially high-impact somatic variants in the genes that encode PI3K, which may explain why AS-605240 does not singly inhibit the proliferation of cell lines. The combination of ibrutinib and AS-605240 represents a promising approach that warrants further in vivo evaluation in dogs, potentially bearing significant value for the treatment of human DLBCL.     

Total synthesis of tumor inhibiting didemnenone analogues

We have previously described an enantioselective total synthesis of the tumor inhibiting didemnenones 1a , b and 2 . Our investigations reported here shed light on the structure–activity relationships of these natural products. The significantly lower activity found for (3aS*, 6aS*)-3 [(E)-allyliden]-2-oxo-6a-(-hydroxymethyl)-2,3,3a,6a-tetrahydro-4H-cyclo-penta[b]furan]2(3H)-one ( 4 ) supported the hypothesis that the oxonium intermediate 3 is the active species. The strategy of the synthesis of the natural products was used to prepare acceptor substituted analogues (3aS*, 6aS*) [(E)-[3-(4-oxo-pent-2-(E)-enylidene]-6a-(4-hydroxymethyl)-2-methoxy-2,3,3a, 6a-tetrahydro[4H-cyclopenta[b]furan]-4-one ( 18 ) and (3aS*, 6aS*) [(E)-[3-(4-oxo-pent-2-(E)-enylidene]-6a-(4-hydroxymethyl)-2,3,3a,6a-tetrahydro-[4H-cyclopenta[b]furan]-2-(3H)-one ( 20 ). Although there were only moderate structural changes some of the key transformations differed remarkably in yield and general performance from those employed in the former synthesis. Optimization of the synthesis rewardingly led to compounds with increased biological activity against human gastric carcinoma cell-lines.     

Zur Aminolyse von Bis-Imidoylchloriden der Oxalsäure. I. Umsetzung mit aromatischen und aliphatischen Aminen

On the Aminolysis of Bis-Imidoylchlorides of Oxalic Acid. Part I. Reaction with Aromatic and Aliphatic Amines The reaction between bis-imidoylchlorides 2 derived from oxalic acid and several aromatic and aliphatic amines was investigated. While primary aromatic amines need a thermical activation by refluxing, primary aliphatic amines give mainly at room temperature the amidines 3 in moderatly up to good yields. Proceeding from enantiomeric pure amines e.g. ( R )- or (S)-1-phenethylamine the new homochiral oxalic amidines 3y and 3z with C₂-symmetry were obtained. Several secondary amines react with the bis-imidoylchloride 2a to give via intramolecular cycloacylation derivatives of isatine. The new synthesized amidines 3 perform systems with a strong molecular dynamic like prototropie and E/Z-interconversion. All new compounds described were characterized by elemental analysis and spectroscopic methods.     

Impact of stress on objectively recorded menopausal hot flushes and on flush report bias.

Investigated the association between stress and both objective (i.e., physiologically recorded) and subjective hot flushes (HFs) among 21 37–71 yr old postmenopausal women who reported having frequent HFs. Ss underwent psychophysiological monitoring during stressful and nonstressful laboratory sessions. Significantly more objective HFs were recorded during the stress session than during the nonstress session. The stress manipulation, however, did not affect Ss' propensity to report HFs. Results suggest that the observed association between reported HFs and stress is not due to changes in report bias. The physiological mechanisms through which stress may stimulate HFs are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A lysine sensor for process control

A lysine sensor for process control of lysine fermentation was developed based on a Clark-type electrode in combination with L -lysine-α-oxidase. The enzyme, isolated from Trichoderma viride, was immobilized between a cellulose and a polypropylene foil using a polyurethane resin. Lysine determinations were carried out in a flow-through system as anodic measurements when H₂O₂ was measured and as chathodic measurements when the consumption of O₂ was followed. The sensitivity of the sensor toward other amino acids was determined.