File-access characteristics of parallel scientific workloads

Phenomenal improvements in the computational performance of multiprocessors have not been matched by comparable gains in I/O system performance. This imbalance has resulted in I/O becoming a significant bottleneck for many scientific applications. One key to overcoming this bottleneck is improving the performance of multiprocessor file systems. The design of a high-performance multiprocessor file system requires a comprehensive understanding of the expected workload. Unfortunately, until recently, no general workload studies of multiprocessor file systems have been conducted. The goal of the CHARISMA project was to remedy this problem by characterizing the behavior of several production workloads, on different machines, at the level of individual reads and writes. The first set of results from the CHARISMA project describe the workloads observed on an Intel iPSC/860 and a Thinking Machines CM-5. This paper is intended to compare and contrast these two workloads for an understanding of their essential similarities and differences, isolating common trends and platform-dependent variances. Using this comparison, we are able to gain more insight into the general principles that should guide multiprocessor file-system design     

Counselor trainees' perceptions of supervisor roles: Two studies testing the dimensionality of supervision.

Two studies were conducted to assess the dimensionality of supervision. The purpose of Study 1 was to identify the salient dimensions of supervision from the counselor trainee's perspective and to determine if dimensions for trainees corresponded to the dimensions found previously for supervisors. In doing so the dimensionality and construct validity of Bernard's (1979) model was examined by using 15 doctoral trainees. For Study 2 Bernard's model was expanded to incorporate the self-supervisor role and was tested in combination with Littrell, Lee-Borden, and Lorenz's (1979) model. Counselor trainees from a master's (n?=?25) and a doctoral (n?=?23) program participated. The three dimensions that emerged in Study 1 and in Study 2 were remarkably consistent in content and label across the two studies. In terms of dimensionality, Bernard's model and the extended model were modestly supported, whereas Littrell et al.'s model received minimal support. Little evidence was found to suggest that trainees from master's and doctoral programs differed at all in terms of their cognitive maps of supervision. Implications and limitations of the studies were discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

My early experiences in developing the practice of psychology.

Relates the author's early experiences as one of the 1st psychologists in the full-time practice of psychotherapy in New York, New York, and his place in the development of sex therapy in the 1940s and 1950s. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A pilot study of the effect of mechanical ventilation and heat exchange on house-dust mites and Der p 1 in New Zealand homes

We have examined the effect of reducing relative humidity (RH), with inbuilt mechanical ventilation and heat-exchange (MVHE) units, on house-dust-mite (HDM) counts and allergen levels, in a pilot study of 10 Wellington dwellings. Recent international prevalence studies in adults and children have confirmed a high prevalence of asthma in New Zealand. Sensitivity to HDM is common among the general population, and HDM is the major allergen associated with asthma. Recent studies of allergen levels have confirmed high concentrations of Der p 1 in the domestic environment. While humidity was significantly reduced in those dwellings fitted with ventilation units, no systematic effect on mites or Der p 1 was observed during the study period. When the reductions in humidity were examined in the context of the time spent below the critical equilibrium humidity (CEH), the intervention led to RH values below the CEH for only 39% of the total of 24-h periods for which measurements were made. Reducing RH by means of MVHE in New Zealand domestic dwellings does not lower humidity sufficiently, or long enough, to have any measurable effect on HDM populations.     

A Study of the Fracture Behavior of Unindirectional Fiber- Reinforced Composite Using Coherent Gradient Sensing (CGS) Interferometry

The feasibility of using Coherent Gradient Sensing (CGS) interferometry for studying the fracture behavior of unidirectional fiber-reinforced composites is investigated in this paper. First, the solution for the deformation field surrounding the tip of a crack in an orthotropic material is summarized. Specifically, the most singular term in the asymptotic expansion is explicitly presented. Then, the quantities that relate to the CGS measurements are derived in terms of the spatial position, stress intensity factors, and material constants. Based on these results, synthetic CGS fringe patterns are plotted numerically, and the effects of material anisotropy and crack-tip mixity on the shape of CGS fringe pattern are investigated. In addition, a finite difference interpretation of CGS fringes caused by the finite spacing of the CGS diffraction gratings is taken into account in the simulation. Finally, the initiation fracture toughness and the subsequent resistance curve behavior of a particular unidirectional graphite/epoxy composite are measured using the CGS method. The optically measured stress intensity factors compare successfully to values obtained from the load measurements and the available analytical solutions. This revised version was published online in August 2006 with corrections to the Cover Date.     

The development and cross-validation of methods based on radioimmunoassay and LC/MS-MS for the quantification of the class III antiarrhythmic agent, MK-0499, in human plasma and urine

An analytical method based on radioimmunoassay (RIA) has been developed for the determination of the antiarrhythmic agent, MK-0499, in plasma and urine. Owing to the potency of the drug, the specificity of this assay in human plasma could not be adequately determined using conventional RIA procedures. A highly specific procedure, based on LC/MS-MS, was developed to cross-validate the RIA. The lower quantifiable limits of the RIA and LC/MS-MS-based methods were 0.05 and 0.013 ng ml-1, respectively. Cross-validation data, compared using paired student's t-test regression analysis, showed excellent correlation between methods. The mass spectrometric assay was also used to simultaneously measure plasma concentrations of unlabeled and 14C-labeled MK-0499 following administration of the drug at high specific activity to volunteers.     

Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function

N-Acetyl aspartate (NAA) is the second most abundant amino acid in the human brain. NAA is synthesized by L-aspartate N-acetyl transferase or by cleavage from N-acetyl aspartyl glutamate by N-acylated alpha-linked L-amino dipeptidase (NAALADase); and it is catabolized to acetate and aspartate by N-acetyl aspartate amino hydrolase (amino acylase II). NAA is localized primarily to neurons, where it is concentrated in the cytosol. Although NAA is devoid of neurophysiological effects, it serves as an acetyl donor, an initiator of protein synthesis or a carbon transfer source across the mitochondrial membrane. The concentration of NAA in human brain increases 3-fold between midgestation and adulthood. In Canavan's Disease, an autosomal recessive disorder due to a null mutation in amino acylase II, NAA levels in brain are markedly increased and disrupt myelination. NAA levels have been found to be reduced in neurodegenerative disorders, including Alzheimer's Disease and Huntington's Disease. Since endogenous NAA can be readily detected in human brain by magnetic resonance spectroscopy, it is increasingly being exploited as a marker for functional and structural integrity of neurons in an expanding number of disorders.