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Thermal insulation is one of the most effective energy-conservation measures in buildings. Despite the widespread use of insulation materials in recent years, little is known regarding their optimum thickness under dynamic thermal conditions. Insulated concrete blocks are among the units most commonly used in the construction of building walls in Saudi Arabia. Typically, the insulation layer thickness is fixed at a value in the range 2.5–7.5 cm, regardless of the climatic conditions, type and cost of insulation material, and other economic parameters. In the present study, a numerical model based on a finite-volume, time-dependent implicit procedure, which has been previously validated, is used to compute the yearly cooling and heating transmission loads under steady periodic conditions through a typical building wall, for different insulation thicknesses. The transmission loads, calculated by using the climatic conditions of Riyadh for a west-facing wall, are fed into an economic model in order to determine the optimum thickness of insulation (Lopt). The latter corresponds to the minimum total cost, which includes the cost of insulation material and its installation plus the present value of energy consumption cost over the lifetime of the building. The optimum insulation thickness depends on the electricity tariff as well as the cost of insulation material, lifetime of the building, inflation and discount rates, and coefficient of performance of the air-conditioning equipment. In the present study, the effect of electricity tariff on the computed optimum insulation thickness is investigated. Different average electricity tariffs are considered; namely, 0.05, 0.1, 0.2, 0.3 and 0.4 SR/kWh (designated as Cases 1–5, respectively; 1 US$ = 3.75 Saudi Riyals). Results using moulded polystyrene as an insulating material show that the values of Lopt are: 4.8, 7.2, 10.9, 13.7 and 16.0 cm for Cases 1–5. Under the conditions of optimal insulation thickness for each electricity tariff, Case 1 gives the lowest total cost of 17.4 SR/m2, while Case 5 gives the highest total cost of 53.1 SR/m2. Corresponding thermal performance characteristics in terms of yearly total and peak transmission loads, R-value, time lag and decrement factor are presented.  相似文献   
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Thoracoscopy provides a minimally invasive technique for the diagnosis and management of many posterior mediastinal masses. Benign neurogenic tumors, esophageal tumors, and bronchogenic cysts all can be approached using video-assisted thoracic surgical (VATS) techniques. Malignant lesions are still best approached via open thoracotomy. VATS techniques allow for less pain and dysfunction and can result in shortened hospital stays.  相似文献   
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Using a reflection magneto-optic technique we have investigated natural inhomogeneities and artificial structures in YBCO thin films exposed to an external magnetic field. The artificial structures were mechanically scratched by scanning a diamond tip with different loading over the film surface. Alternatively planar structures with reduced oxygen content could be patterned by heating the YBCO film with a focused laser beam in nitrogen atmosphere. Depending on the laser annealing parameters different screening properties concerning the applied magnetic field could be achieved.As a magneto-optically active layer we used EuS films evaporated on glass as well as bismuth- and gallium-doped lutetium-iron-garnet films grown onto (111) oriented gadolinium-gal lium-gar net substrates by liquid phase epitaxy. In contrast to measurements with EuS films that show only weak faraday rotation for temperatures higher than 20 K the magneto-optic studies have been expanded to about 60 K by using the garnet films.  相似文献   
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Su Vida, Su Salud/Your Life, Your Health is a community program to increase participation in breast and cervical cancer screening. This program illustrates the diffusion of an innovative outreach strategy from a research environment to two local health departments. The program uses A Su Salud, the communication model in which positive role models are featured in the media, and community volunteers who give positive social reinforcement. Local health departments in Galveston and Corpus Christi, TX, were selected to implement the model because of excessive mortality rates in the region and the departments' adequate level of resources and commitment. Over an 18-month period, 54 stories of role models appeared in the media in Corpus Christi, and 60 appeared in Galveston. There were 490 volunteers active in Corpus Christi and 279 in Galveston. Of 365 inquiries to the Corpus Christi program, 35 percent were from the Mexican American target group of women ages 40-70. Of 1,457 women who contacted the Galveston program, 9 percent were from the African American target group ages 40-70. Local health departments are well-suited to participation in cancer control research applications because they have direct access to high-risk populations and have the authority to institutionalize effective interventions.  相似文献   
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Combinations of EDTA-Tris and two aminoglycoside antibiotics (amikacin and neomycin) were tested for synergistic activities against the microorganisms associated with otitis externa in dogs and for the solutions' stability over time. Synergistic activity was observed when EDTA-Tris plus amikacin and EDTA-Tris plus neomycin were tested against Staphylococcus intermedius, Proteus mirabilis, Pseudomonas aeruginosa, and Escherichia coli, but not against Candida albicans. Stability studies over a 3-month period indicated that the test solutions were stable at room temperature and that their antimicrobial activity was maintained.  相似文献   
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Recognition by integrin proteins on the cell surface regulates the adhesive interactions between cells and their surroundings. The structure of the 'I' domain that is found in some but not all integrins, has been determined. However, the only integrin ligands for which structures are known, namely fibronectin and VCAM-1, are recognized by integrins that lack I domains. The intercellular adhesion molecules ICAM-1, 2 and 3 are, like VCAM-1, members of the immunoglobulin superfamily (IgSF), but they are recognized by an I domain-containing integrin, lymphocyte-function-associated antigen 1 (LFA-1, or CD11a/CD18). Here we present the crystal structure of the extracellular region of ICAM-2. The glutamic acid residue at position 37 is critical for LFA-1 binding and is proposed to coordinate the Mg2+ ion in the I domain; this Glu 37 is surrounded by a relatively flat recognition surface and lies in a beta-strand, whereas the critical aspartic acid residue in VCAM-1 and fibronectin lie in protruding loops. This finding suggests that there are differences in the architecture of recognition sites between integrins that contain or lack I domains. A bend between domains 1 and 2 of ICAM-2 and a tripod-like arrangement of N-linked glycans in the membrane-proximal region of domain 2 may be important for presenting the recognition surface to LFA-1. A model of ICAM-1 based on the ICAM-2 structure provides a framework for understanding its recognition by pathogens.  相似文献   
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