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61.
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针对领域自适应问题中源域和目标域的联合分布差异最小化问题,提出两阶段领域自适应学习方法.在第一阶段考虑样本标签和数据结构的判别信息,通过学习一个共享投影变换,使投影后的共享空间中边缘分布的差异最小.第二阶段利用源域标记数据和目标域非标记数据学习一个带结构风险的自适应分类器,不仅能最小化源域和目标域条件分布差异,还能进一步保持源域和目标域边缘分布的流形一致性.在3个基准数据集上的实验表明,文中方法在平均分类准确率和Kappa系数两项评价指标上均表现较优. 相似文献
63.
The polyamide 6-polyurethane copolymer (PA6-b-PU-b-PA6) was synthesized through anionic suspension polymerization and then mixed with polyamide 6/thermoplastic polyurethane (PA6/TPU) and polyamide 6, 6/thermoplastic polyurethane (PA66/TPU) blends using as the compatibilizer. The results show that the PA6-b-PU-b-PA6 copolymers powders several can be obtained through suspension polymerization using dimethicone as disperse medium. The average diameter of PA6-b-PU-b-PA6 copolymer powders decreased with the increasing of PU content. With the addition of PA6-b-PU-b-PA6, the TPU phase dispersed more uniformly in PA6 or PA66 matrix, and the size of TPU dispersed phase decreased obviously. The PA6-b-PU-b-PA6 copolymer with higher PU content shows better compatibilizing effect. Addition of PA6-b-PU-b-PA6 can improve both strength and toughness of the PA/TPU blends. When the amount of PA6-PU25% copolymer was 5 phr, the tensile strength and notched impact strength of PA6/TPU/PA6-PU25% blends increased 29 and 159.4%, respectively, compared to the PA6/TPU blend without compatibilizer. 相似文献
64.
食物成瘾的研究进展及启示 总被引:2,自引:0,他引:2
食物成瘾是一种复杂的慢性疾病,导致人们在日常生活中对某种食物产生过度依赖与过度进食等相关行为特征,近年来已被认为是影响欧美发达国家肥胖症、暴食症、糖尿病等发病率持续升高的关键原因,引起学术界的极大关注,成为研究热点。本文主要介绍食物成瘾的概念、诊断标准,综述了食物成瘾的病理机制、影响因素和应对措施等方面的研究进展,并探讨食物成瘾对我国食品界的启示,为预防食物成瘾,保障公众健康提供有益借鉴。 相似文献
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Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
69.
Baizhan Li Chenqiu Du Hong Liu Wei Yu Jie Zheng Meilan Tan Zhenxing Jin Wenjie Li Jing Wu Lu Chen Runming Yao 《Indoor air》2019,29(2):308-319
The extensive research interests in environmental temperature can be linked to human productivity / performance as well as comfort and health; while the mechanisms of physiological indices responding to temperature variations remain incompletely understood. This study adopted a physiological sensory nerve conduction velocity (SCV) as a temperature‐sensitive biomarker to explore the thermoregulatory mechanisms of human responding to annual temperatures. The measurements of subjects’ SCV (over 600 samples) were conducted in a naturally ventilated environment over all four seasons. The results showed a positive correlation between SCV and annual temperatures and a Boltzmann model was adopted to depict the S‐shaped trend of SCV with operative temperatures from 5°C to 40°C. The SCV increased linearly with operative temperatures from 14.28°C to 20.5°C and responded sensitively for 10.19°C‐24.59°C, while tended to be stable beyond that. The subjects’ thermal sensations were linearly related to SCV, elaborating the relation between human physiological regulations and subjective thermal perception variations. The findings reveal the body SCV regulatory characteristics in different operative temperature intervals, thereby giving a deeper insight into human autonomic thermoregulation and benefiting for built environment designs, meantime minimizing the temperature‐invoked risks to human health and well‐being. 相似文献
70.
Neural Processing Letters - The beta processes (BP) is a powerful nonparametric tool in feature learning, which is often used as the prior of Bernoulli process for choosing features from a feature... 相似文献