Creating the brain and interacting with the brain: an integrated approach to understanding the brain

In the past two decades, brain science and robotics have made gigantic advances in their own fields, and their interactions have generated several interdisciplinary research fields. First, in the ‘understanding the brain by creating the brain’ approach, computational neuroscience models have been applied to many robotics problems. Second, such brain-motivated fields as cognitive robotics and developmental robotics have emerged as interdisciplinary areas among robotics, neuroscience and cognitive science with special emphasis on humanoid robots. Third, in brain–machine interface research, a brain and a robot are mutually connected within a closed loop. In this paper, we review the theoretical backgrounds of these three interdisciplinary fields and their recent progress. Then, we introduce recent efforts to reintegrate these research fields into a coherent perspective and propose a new direction that integrates brain science and robotics where the decoding of information from the brain, robot control based on the decoded information and multimodal feedback to the brain from the robot are carried out in real time and in a closed loop.     

Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5

This article discloses a new horizon for the application of peroxides in medical chemistry. Stable cyclic peroxides are demonstrated to have cytotoxic activity against cancer cells; in addition a mechanism of cytotoxic action is proposed. Synthetic bridged 1,2,4,5-tetraoxanes and ozonides were effective against HepG2 cancer cells and some ozonides selectively targeted liver cancer cells (the selectivity indexes for compounds 11 b and 12 a are 8 and 5, respectively). In some cases, tetraoxanes and ozonides were more selective than paclitaxel, artemisinin, and artesunic acid. Annexin V flow-cytometry analysis revealed that the active ozonides 22 a and 23 a induced cell death of HepG2 by apoptosis. Further study showed that compounds 22 a and 23 a exhibited a strong inhibitory effect on P-glycoprotein (P-gp/ABCB5)-overexpressing HepG2 cancer cells. ABCB5 is a key player in the multidrug-resistant phenotype of liver cancer. Peroxides failed to demonstrate a direct correlation between oxidative potential and their biological activity. To our knowledge this is the first time that peroxide diastereoisomers have been found to show stereospecific antimalarial action against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Stereoisomeric ozonide 12 b is 11 times more active than stereoisomeric ozonide 12 a (IC₅₀=5.81 vs 65.18 μm ). Current findings mean that ozonides merit further investigation as potential therapeutic agents for drug-resistant hepatocellular carcinoma.     

可持续煤矿矿井水处理与资源化技术综述

煤矿开采过程中会产生大量的废弃矿井水,不仅造成水资源的大量浪费,而且还威胁着矿区生态环境。本文综述了我国常见矿井水的常规处理方法,以及将矿井水视为水资源的可持续矿井水水处理与资源化技术,首次提出以“时间维度和空间维度”对矿井水进行全时空处理,并着重阐述了矿井水分级处理、分质利用技术,反渗透浓水处理与资源化技术,煤泥处理与资源化技术,以及重金属回收与利用技术等,对煤矿区矿井水处理与资源化利用具有指导意义。     

硅渣和玻璃粉直接烧结制备多孔材料的气孔结构与力学性能

以硅渣和玻璃粉为原料,采用粉体直接烧结法制备多孔材料,研究了烧结温度(700~900℃)、烧结时间(15~120min)和升温速率(10~100℃·min^-1)对多孔材料表观密度、气孔率、物相组成、抗压强度的影响。结果表明:气孔结构均匀性随烧结温度的升高而降低;表观密度随烧结温度的升高先减小后增大,随保温时间的延长而增大,随升温速率的增大而减小,气孔率的变化趋势与表观密度的相反;多孔材料的主要物相为玻璃相和硅、SiC、SiO2、Ca2Al2SiO7等结晶相,且结晶度随烧结温度的升高而降低;抗压强度随烧结温度的升高呈先增大后减小的趋势;当烧结温度为750℃,升温速率为30℃·min^-1,烧结时间为30 min时,多孔材料的主晶相为硅和Ca2Al2SiO7,抗压强度最大(1.60MPa),表观密度为0.43g·cm^-3,气孔率为80%。     

基于聚类的数据加权优化在犯罪预测中的应用

近年来，我国传统暴力犯罪与成年人犯罪呈下降态势，但是，犯罪案由层出不穷。为有效提升公安实践工作中犯罪预测能力，打击各类违法犯罪事件,本文针对犯罪数据，提出一种新型犯罪预测模型。利用密度聚类分析方法将犯罪数据分类，然后进行数据降维提取关键属性生成特征数据，继而对特征数据进行加权优化并采用机器学习的方式对特征数据进行学习，从而预测犯罪案由。实验结果表明，与传统方法相比，本文方法具有更好的预测效果，为公安实践工作中类似案件的侦破和预防，提供新的路径支撑。     

某高校既有建筑室内人员相关VOCs目标污染物的实测分析

为研究高校既有建筑室内人群散发对室内VOCs的影响，对高校不同人群样本的教室及会议室两类典型人群密集房间，共82个人群样本对象进行了VOCs采样分析，得到不同实际场景下的人员相关的VOCs浓度水平，并对其潜在的影响因素进行分析。结果表明，共确认了29种与室内人员相关的高检出率且较高浓度值的物质，包括芳香族化合物9种，烷烯烃类9种，酮类和醛类8种，醇酯类以及卤化物3种，并得到主要VOCs物质的浓度水平和I/O比。对影响因素的统计分析表明，室内人员密度、季节和房间类型对不同VOCs物质存在显著性影响，其中季节性因素对目标VOCs污染物影响最为广泛，其次是房间类型与室内人员密度。该研究可为进一步了解人员密集室内VOCs污染现状及控制策略提供一定的科学参考。     

新工科背景下智能控制电路项目实践课程改革研究

针对当前智能控制电路项目实践课程存在问题,进行原因分析,并提出引入国际先进的教育模式——OBE模式的"8"字形课程架构,提出了课程设计和教学策略等方面的创新措施。     

某工业厂房主体结构安全性评定探讨

结构的安全性是结构防止破坏倒塌的能力,是结构工程重要的质量指标.老工业基地中的厂房主体结构安全性评价,对于厂房加固改造起到了关键性作用.文中通过对某工业厂房主体结构大量现场勘验、隐患排查及检测数据,结合结构验算,从承载能力、损伤等几方面对该老旧工业厂房的安全性进行了评价与分析,并详细介绍了检测鉴定的流程,为以后类似的老旧工业厂房的检测鉴定提供参考.