全文获取类型
收费全文 | 461265篇 |
免费 | 91555篇 |
国内免费 | 58007篇 |
专业分类
电工技术 | 47296篇 |
技术理论 | 15篇 |
综合类 | 42162篇 |
化学工业 | 65335篇 |
金属工艺 | 39763篇 |
机械仪表 | 25948篇 |
建筑科学 | 35008篇 |
矿业工程 | 21652篇 |
能源动力 | 16651篇 |
轻工业 | 40237篇 |
水利工程 | 13309篇 |
石油天然气 | 27358篇 |
武器工业 | 6385篇 |
无线电 | 60724篇 |
一般工业技术 | 59100篇 |
冶金工业 | 18411篇 |
原子能技术 | 4407篇 |
自动化技术 | 87066篇 |
出版年
2024年 | 2756篇 |
2023年 | 8490篇 |
2022年 | 12784篇 |
2021年 | 17332篇 |
2020年 | 17293篇 |
2019年 | 24125篇 |
2018年 | 26410篇 |
2017年 | 28657篇 |
2016年 | 27209篇 |
2015年 | 30188篇 |
2014年 | 32295篇 |
2013年 | 34342篇 |
2012年 | 36226篇 |
2011年 | 34189篇 |
2010年 | 31137篇 |
2009年 | 27052篇 |
2008年 | 25039篇 |
2007年 | 23474篇 |
2006年 | 21652篇 |
2005年 | 18217篇 |
2004年 | 16740篇 |
2003年 | 14328篇 |
2002年 | 13839篇 |
2001年 | 12271篇 |
2000年 | 10743篇 |
1999年 | 10029篇 |
1998年 | 8116篇 |
1997年 | 7002篇 |
1996年 | 6667篇 |
1995年 | 6161篇 |
1994年 | 4995篇 |
1993年 | 4163篇 |
1992年 | 3752篇 |
1991年 | 2727篇 |
1990年 | 2173篇 |
1989年 | 1942篇 |
1988年 | 1488篇 |
1987年 | 587篇 |
1986年 | 510篇 |
1985年 | 354篇 |
1984年 | 251篇 |
1983年 | 178篇 |
1982年 | 233篇 |
1981年 | 223篇 |
1980年 | 166篇 |
1976年 | 243篇 |
1975年 | 216篇 |
1972年 | 239篇 |
1971年 | 130篇 |
1960年 | 209篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
Juan José Burbano He/him Darío Marcelino Cabezas María Jimena Correa 《International Journal of Food Science & Technology》2022,57(8):4772-4781
Walnut flour (WF), a by-product of walnut oil production, is characterised by high polyunsaturated fatty acids, proteins, and fibre contents and presents suitability for bakery products. However, when using non-traditional ingredients, it is essential to evaluate the effect on the quality properties of the final product. So, this work aimed to assess the impact of WF on the technological, physicochemical, and sensory properties of gluten-free (GF) cakes. WF was added at a flour blend (cassava (CS) and maize (MS) starches and rice flour) at 0, 10%, 15%, and 20%. The results showed that WF modified starch gelatinisation, increased amylose–lipid complex (ALC) content, and made crumbs easier to chew. Besides, the total dietary fibre (TDF) and protein content significantly increased. Cakes with 15% WF presented the highest specific volume (SV) and no differences in overall acceptability with respect to control. Hence, WF is a suitable ingredient for gluten-free bakery products. 相似文献
53.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
54.
55.
Jinshuang Wang Luyao Chen Mengdi Chen Yuyang Wu Yinghui Wang Yongsheng Yu Junbin Sun Bing Liu Qiangshan Jing 《Ceramics International》2021,47(16):22965-22975
In this study, the destabilization resistance of Sc2O3 and CeO2 co-stabilized ZrO2 (SCZ) ceramics was tested in Na2SO4 + V2O5 molten salts at 750°C–1100 °C. The phase structure and microstructure evolution of the samples during the hot corrosion testing were analyzed with X-ray diffraction (XRD), Raman spectra, scanning electron microscopy (SEM), energy dispersive X-ray spectrum (EDS), and X-ray photoelectron spectroscopy (XPS). Results showed that the destabilization of SCZ ceramics at 750 °C was the result of the chemical reaction with V2O5 to produce m-ZrO2 and CeVO4, and little ScVO4 was detected in the Sc2O3-rich SCZ ceramics. The primary corrosion products at 900 °C and 1100 °C were CeO2 and m-ZrO2 due to the mineralization effect. The Sc2O3-rich SCZ ceramics exhibited excellent degradation resistance and phase stability owing to the enhanced bond strength and the decreased size misfit between Zr4+ and Sc3+. The destabilization mechanism of SCZ ceramic under hot corrosion was also discussed. 相似文献
56.
Li Qian Chen Yan Sun Shikun Zhu Muyuan Xue Jing Gao Zihan Zhao Jinfeng Tang Yihe 《Water Resources Management》2022,36(12):4799-4817
Water Resources Management - Increasing water consumption in agriculture due to global climate change has posed considerable challenges to food security, thus improving the efficiency of water... 相似文献
57.
Virtual Reality - BRICKxAR is a novel augmented reality (AR) instruction method for construction toys such as LEGO®. With BRICKxAR, physical LEGO construction is guided by virtual bricks.... 相似文献
59.
Cho-Yi Chen Masaoki Kawasumi Tien-Yun Lan Chi-Lam Poon Yi-Sian Lin Pin-Jou Wu Yao-Chung Chen Bing-Hong Chen Cheng-Hsien Wu Jeng-Fan Lo Rueyhung Roc Weng Yi-Chen Sun Kai-Feng Hung 《International journal of molecular sciences》2021,22(1)
Endoplasmic reticulum (ER) stress response is an adaptive program to cope with cellular stress that disturbs the function and homeostasis of ER, which commonly occurs during cancer progression to late stage. Late-stage cancers, mostly requiring chemotherapy, often develop treatment resistance. Chemoresistance has been linked to ER stress response; however, most of the evidence has come from studies that correlate the expression of stress markers with poor prognosis or demonstrate proapoptosis by the knockdown of stress-responsive genes. Since ER stress in cancers usually persists and is essentially not induced by genetic manipulations, we used low doses of ER stress inducers at levels that allowed cell adaptation to occur in order to investigate the effect of stress response on chemoresistance. We found that prolonged tolerable ER stress promotes mesenchymal–epithelial transition, slows cell-cycle progression, and delays the S-phase exit. Consequently, cisplatin-induced apoptosis was significantly decreased in stress-adapted cells, implying their acquisition of cisplatin resistance. Molecularly, we found that proliferating cell nuclear antigen (PCNA) ubiquitination and the expression of polymerase η, the main polymerase responsible for translesion synthesis across cisplatin-DNA damage, were up-regulated in ER stress-adaptive cells, and their enhanced cisplatin resistance was abrogated by the knockout of polymerase η. We also found that a fraction of p53 in stress-adapted cells was translocated to the nucleus, and that these cells exhibited a significant decline in the level of cisplatin-DNA damage. Consistently, we showed that the nuclear p53 coincided with strong positivity of glucose-related protein 78 (GRP78) on immunostaining of clinical biopsies, and the cisplatin-based chemotherapy was less effective for patients with high levels of ER stress. Taken together, this study uncovers that adaptation to ER stress enhances DNA repair and damage tolerance, with which stressed cells gain resistance to chemotherapeutics. 相似文献
60.
胶莱盆地在胶东半岛地质构造及造山带研究中占有重要地位,其巨厚的白垩系陆相沉积是石油系统多年的研究目标。胶莱盆地南部白垩纪的岩石地层序列较其北部更为复杂,其认识几经反复,其中尤以大盛群与王氏群和莱阳群的部分单位的关系为甚。本次工作通过详细对比其沉积层序、相互关系、古生物组合、岩石学特征及同位素年龄等因素,认为大盛群与王氏群属同一沉积层序,沉积基底相同、沉积环境相似、古生物群落时代一致,二者具有同时代、同沉积相、同岩石组合的一致性,应是一套地层,建议今后使用统一地层名称。 相似文献