A machine learning system for identifying transmembrane domains from amino acid sequences

We present our machine learning system, that uses inductive logic programming techniques to learn how to identify transmembrane domains from amino acid sequences. Our system facilitates the use of operators such as ‘contains’, that act on entire sequences, rather than on individual elements of a sequence. The prediction accuracy of our new system is around 93%, and this compares favourably with earlier results. This work was carried out with the support of a research grant from ISIS, Fujitsu Laboratories.     

Measurements of Stress Intensity Factors of an Interface Crack Under Mixed Mode Loading

The optical method of caustics has been utilised to measure both the stress intensity factor for a crack lying along the interface of an aluminium/epoxy bimaterial specimen, and the mode mixity arising from the difference in the elastic properties across the interface. Measurements were carried out by using a novel modification to the method whereby caustics are produced and measured from both sides of the specimen, so compensating automatically for the distortion induced in the specimen due to misaligned loading fixtures. A flat reflective surface across the interface was obtained by adhering a reflective coating to the specimen. Verification that this coating does not affect measurement accuracy was obtained by comparing stress intensity factors measured from coated and uncoated monolithic aluminium specimens where good agreement was found to exist between both measurements.     

Effect of short-term storage on phenolic content,o-diphenolase and peroxidase activities of cut yam tubers (Dioscorea sp)

The effect of short-term storage on the protein, phosphorus and phenolic content as well as peroxidase and o-diphenolase activities of cut, harvested Jamaican yam (Dioscorea sp) tubers (D rotundata. D alata and D cayenensis) was studied. There was an initial increase in the total phenolic content up to the third week of storage followed by a gradual decrease to the sixth week. Phenolic content was found to be highest in D cayenensis followed by D rotundata and D alata. The activities of peroxidase (EC 1. 11. 1. 7) and o-diphenolase (EC 1. 10.3.1) increased steadily up to the third week of storage and thereafter decreased to the fifth week. The intensity and rapidity of browning in tubers when cut, correlated very closely with the tuber o-diphenolase and phenolic content levels while the onset of rotting correlated with the peroxidase activity levels in the species studied.     

Studies on the interactions of metal oxides and Na2 SO4 at 1100 and 1200 K in oxygen

The interaction of different metal oxides such as Co₃O₄, NiO, Al₂O₃, Cr₂O₃, Fe₂O₃ and SiO₂ with Na₂SO₄ at a temperature of 1100 and 1200 K in flowing oxygen has been studied. The thermogravimetric studies for each system were carried out as a function of Na₂SO₄ in the mixture. The presence of different constituents in the reaction products were identified by X-ray diffraction analysis and the morphologies of the reaction products were characterized using metallography and scanning electron microscopy (SEM). The formation of products was also investigated by thermodynamic computation of free energies of the reactions and the study of relevant equilibrium phase diagrams. The soluble species in the aqueous solutions of the reaction products were determined quantitatively using atomic absorption spectrophotometry. The high temperature interaction products usually contain a 3-phase structure namely, Na₂O·M₂O _x , M₂O _x and metal sulphide and/or metal sulphate. The formation of Na₂O·M₂O _x depends upon the solid state solubility of metal oxide in the molten salt at high temperatures. Under limited solubility conditions Na₂O·M₂O _x is invariably formed, but as soon as this condition is relaxed the oxide. M₂O _x , precipitates and forms a separate phase.     

The effect of OPWF filler on impact strength of glass-fiber reinforced epoxy composite

In the present study, oil palm wood flour (OPWF) particles with less than 250 μm sizes have been used as filler materials in the woven-glass-fiber reinforced epoxy composite. The hybrid composites were fabricated using a hand lay-up method and cured at room temperature under a compressive load of 196 N (20 kg). The OPWF of 2.5 to 10 parts per hundred (pph) by weight was used to evaluate its effect on impact strength of the hybrid composites at a range of temperature from −50 to 50 °C. The impact strength, evaluated using V-notch Charpy method, showed reduction with increasing filler content up to 5 pph and then the strength increment in those composites containing more than 5 pph OPWF. More severe damages were found in specimens with higher filler contents resulting higher energy absorption during impact. The composites with a large amount of OPWF particles deflected crack propagation paths or created obstacles at the crack tips and increased toughness of the composites. The impact strength was found to decrease when the samples fractured at subzero temperatures and this happened because of the reduction of the matrix ductility at lower temperatures.     

Electrical Insulation Characteristics of Silicone and EPDM Polymeric Blends. I

The typical parts of a polymeric insulator are core, metal end fittings and polymeric housing material. The housing is intended to protect the fibre glass rod from the environment and electrical surface discharges. Since the housing materials are made of organic polymeric material, its insulation characteristics need to be studied. Amongst the many different polymers available, this work focuses on silicone rubber and ethylene propylene diene monomer (EPDM). Blends of EPDM and silicone rubber are prepared in a two roll mixing mill. Dicumyl peroxide is used as vulcanizing agent. The blends consisting of various proportions of component polymers are prepared, compression moulded into sheets, and post cured. The blends are tested for their insulation characteristics as per IEC and ASTM standards. Volume and surface resistivity, dielectric strength, dielectric constant, tan delta, tracking resistance, arc resistance, comparative tracking index, tensile strength, and percentage elongation at break of the blends are studied and discussed. The test results show that the increasing proportion of silicone enhances the electrical insulation properties whereas increasing weight percentage of EPDM improves the mechanical strength of the blends.     

Multidimensional vector radix FHT algorithms

In this paper, efficient multidimensional (M-D) vector radix (VR) decimation-in-frequency and decimation-in-time fast Hartley transform (FHT) algorithms are derived for computing the discrete Hartley transform (DHT) of any dimension using an appropriate index mapping and the Kronecker product. The proposed algorithms are more effective and highly suitable for hardware and software implementations compared to all existing M-D FHT algorithms that are derived for the computation of the DHT of any dimension. The butterflies of the proposed algorithms are based on simple closed-form expressions that allow easy implementations of these algorithms for any dimension. In addition, the proposed algorithms possess properties such as high regularity, simplicity and in-place computation that are highly desirable for software and hardware implementations, especially for the M-D applications. A close relationship between the M-D VR complex-valued fast Fourier transform algorithms and the proposed M-D VR FHT algorithms is established. This type of relationship is of great significance for software and hardware implementations of the algorithms, since it is shown that because of this relationship and the fact that the DHT is an alternative to the discrete Fourier transform (DFT) for real data, a single module with a little or no modification can be used to carry out the forward and inverse M-D DFTs for real- or complex-valued data and M-D DHTs. Thus, the same module (with a little or no modification) can be used to cover all domains of applications that involve the DFTs or DHTs.     

Lowpass and bandpass transadmittance filter using operational amplifier pole

A new topology simultaneously implementing lowpass (LP) and bandpass (BP) transadmittance filtering signals using a single operational amplifier (OA), one capacitor, and two resistors is presented. The input impedance is very high which is essential for cascading without employment of buffers. The circuit uses absolute minimum number of active and passive components. The filter employs pole-model of OA and as such has acquired suitability for extended frequency operation. The circuit permits separate adjustment of natural frequency (ω₀) and quality factor (Q) in an orthogonal manner. The circuit has low sensitivity figures unlike the reported single amplifier biquads. The PSPICE simulation results are included.