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排序方式: 共有3504条查询结果,搜索用时 15 毫秒
71.
James Lawler Zheng Li Nasir Javed Dennis Anderson Jonathan Hill Hortense Howell-barber 《Information Systems Management》2005,22(1):66-76
This study examines the significance of technological, methodological, and business factors in contributing to the success of initial Web Services projects. Focusing on four case studies from the financial services sector, the authors' findings suggest that a strong focus on business factors is associated with successful Web Services strategies. 相似文献
72.
Kate Sanders Sally Fincher Dennis Bouvier Gary Lewandowski Briana Morrison Laurie Murphy Marian Petre Brad Richards Josh Tenenberg Lynda Thomas Richard Anderson Ruth Anderson Sue Fitzgerald Alicia Gutschow Susan Haller Raymond Lister Renée McCauley John McTaggart Christine Prasad Terry Scott Dermot Shinners-Kennedy Suzanne Westbrook Carol Zander 《Expert Systems》2005,22(3):121-128
Abstract: This paper presents a case study of the use of a repeated single‐criterion card sort with an unusually large, diverse participant group. The study, whose goal was to elicit novice programmers' knowledge of programming concepts, involved over 20 researchers from four continents and 276 participants drawn from 20 different institutions. In this paper we present the design of the study and the unexpected result that there were few discernible systematic differences in the population. The study was one of the activities of the National Science Foundation funded Bootstrapping Research in Computer Science Education project (2003). 相似文献
73.
Hannes M. Findeisen Vivienne C. Voges Laura C. Braun Jannik Sonnenberg Dennis Schwarz Helena Krner Holger Reinecke Yahya Sohrabi 《International journal of molecular sciences》2022,23(11)
Reprogramming of metabolic pathways in monocytes and macrophages can induce a proatherosclerotic inflammatory memory called trained innate immunity. Here, we have analyzed the role of the Liver X receptor (LXR), a crucial regulator of metabolism and inflammation, in oxidized low-density lipoprotein (oxLDL)-induced trained innate immunity. Human monocytes were incubated with LXR agonists, antagonists, and oxLDL for 24 h. After five days of resting time, cells were restimulated with the TLR-2 agonist Pam3cys. OxLDL priming induced the expression of LXRα but not LXRβ. Pharmacologic LXR activation was enhanced, while LXR inhibition prevented the oxLDL-induced inflammatory response. Furthermore, LXR inhibition blocked the metabolic changes necessary for epigenetic reprogramming associated with trained immunity. In fact, enrichment of activating histone marks at the IL-6 and TNFα promotor was reduced following LXR inhibition. Based on the differential expression of the LXR isoforms, we inhibited LXRα and LXRβ genes using siRNA in THP1 cells. As expected, siRNA-mediated knock-down of LXRα blocked the oxLDL-induced inflammatory response, while knock-down of LXRβ had no effect. We demonstrate a specific and novel role of the LXRα isoform in the regulation of oxLDL-induced trained immunity. Our data reveal important aspects of LXR signaling in innate immunity with relevance to atherosclerosis formation. 相似文献
74.
Atomic Insights into the Enhanced Surface Stability in High Voltage Cathode Materials by Ultrathin Coating 下载免费PDF全文
Xin Fang Feng Lin Dennis Nordlund Matthew Mecklenburg Mingyuan Ge Jiepeng Rong Anyi Zhang Chenfei Shen Yihang Liu Yu Cao Marca M. Doeff Chongwu Zhou 《Advanced functional materials》2017,27(7)
Surface properties of electrode materials play a critical role in the function of batteries. Therefore, surface modifications, such as coatings, have been widely used to improve battery performance. Understanding how these coatings function to improve battery performance is crucial for both scientific research and applications. In this study the electrochemical performance of coated and uncoated LiNi0.5Mn1.5O4 (LNMO) electrodes is correlated with ensemble‐averaged soft X‐ray absorption spectroscopy (XAS) and spatially resolved scanning transmission electron microscopy‐electron energy loss spectroscopy (STEM‐EELS) to illustrate the mechanism of how ultrathin layer Al2O3 coatings improve the cycle life of LiNi0.5Mn1.5O4. Mn2+ evolution on the surface is clearly observed in the uncoated sample, which results from the reaction between the electrolytic solution and the surfaces of LiNi0.5Mn1.5O4 particles, and also possibly atomic structure reconstructions and oxygen loss from the surface region in LiNi0.5Mn1.5O4. The coating effectively suppresses Mn2+ evolution and improves the battery performance by decelerating the impedance buildup from the surface passivation. This study demonstrates the importance of combining ensemble‐averaged techniques (e.g., XAS) with localized techniques (e.g., STEM‐EELS), as the latter may yield unrepresentative information due to the limited number of studied particles, and sheds light on the design of future coating processes and materials. 相似文献
75.
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77.
This paper considers the fixed-structure, discrete-time mixed H 2 / H X controller synthesis problem in the delta operator (difference operator) framework. The differential operator and shift operator versions of the problem are reviewed for comparison, and necessary conditions are derived for all three formulations. A quasi-Newton/continuation algorithm is then used to obtain approximate solutions to these equations. Controllers are synthesized for two numerical examples, and the performance of the algorithm on the differential, difference and shift operator versions of the problems is compared. 相似文献
78.
Otis Smart Douglas MausEric Marsh Dennis DlugosBrian Litt Kimford Meador 《Expert systems with applications》2012,39(8):7355-7370
Localizing an epileptic network is essential for guiding neurosurgery and antiepileptic medical devices as well as elucidating mechanisms that may explain seizure-generation and epilepsy. There is increasing evidence that pathological oscillations may be specific to diseased networks in patients with epilepsy and that these oscillations may be a key biomarker for generating and indentifying epileptic networks. We present a semi-automated method that detects, maps, and mines pathological gamma (30-100 Hz) oscillations (PGOs) in human epileptic brain to possibly localize epileptic networks. We apply the method to standard clinical iEEG (<100 Hz) with interictal PGOs and seizures from six patients with medically refractory epilepsy. We demonstrate that electrodes with consistent PGO discharges do not always coincide with clinically determined seizure onset zone (SOZ) electrodes but at times PGO-dense electrodes include secondary seizure-areas (SS) or even areas without seizures (NS). In 4/5 patients with epilepsy surgery, we observe poor (Engel Class 4) postsurgical outcomes and identify more PGO-activity in SS or NS than in SOZ. Additional studies are needed to further clarify the role of PGOs in epileptic brain. 相似文献
79.
Although theoretically necessary, social capital is usually not considered within the process of asset allocation for private
investors. Both the lack of appropriate practical valuation concepts and the effort of providing and processing the required
information as input for a valuation have been obstacles to properly include social capital in this process. However, first
theoretical financial models for the evaluation of social capital have recently become available. Moreover, the fast growth
of business community websites and the technological progress in Web 2.0 tools that allow and acquire the active involvement
of users, facilitate the provision and processing of valuation-relevant information. In this paper we focus on this second
aspect and propose a social software-based concept that allows for an integration of social capital in the asset allocation
process. 相似文献
80.