Formulation and in vitro evaluation of bisphosphonate loaded microspheres for implantation in osteolysis

Chitosan and poly(lactide-co-glycolide) acid (PLGA) microspheres loaded with alendronate sodium (AS) were prepared for orthopedic as well as dental applications. In orthopedics the aim was to make the total joint prostheses stay in the body for a long time without causing bone tissue loss, while in dentistry it was aimed to treat the alveolar bone resorption caused by periodontitis and also to make the dental treatment using implants easier by reducing the bone loss in patients with osteoporosis. Solvent evaporation method was used to prepare AS loaded PLGA microspheres and emulsion polimerization method was used to prepare AS loaded chitosan microspheres. Particle size, loading efficacy, surface characteristics, and in vitro release characteristics were examined on prepared formulations. After the examination of the scanning electron microscopy photographs of microspheres, chitosan microspheres were observed to have spherical structure and smooth surface characteristics while PLGA microspheres were observed to have spherical porous surface structure. Loading efficacy was found to be 3.30% for chitosan microspheres and 7.70% for PLGA microspheres. It was observed that 85% of AS had been released at the end of the third day from chitosan microspheres whereas 58% was released at the end of the fifth day from PLGA microspheres. It was found that chitosan microspheres gave first order release while PLGA microspheres gave zero order release.     

Sub-nanomolar sensing of ionic mercury with polymeric electrospun nanofibers

Ethyl cellulose (EC) based electrospun nanofibers were exploited for sub-nanomolar level optical chemical sensing of ionic mercury. An azomethine ionophore was used as Hg (I) and Hg (II) sensing material. Ethyl cellulose nanofibers with varying amounts of the ionic liquid; 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF₄) were prepared and characterized. The nanofibers were fabricated by electrospinning technique. The offered chemosensor allow determination of mercury ions in a large linear working range between 1.0 × 10⁻¹⁰ and 1.0 × 10⁻⁴ mol L⁻¹. Limit of detection was found to be 0.07 nM which makes this technique alternative to cold-vapor atomic absorption spectrometry (CV-AAS), flame emission methods and to inductively coupled plasma-mass spectrometry (ICP-MS).     

A Comparison of Single- and Multi-Objective Programming Approaches to Problems with Multiple Design Objectives

In this paper, we propose and compare single- and multi-objective programming (MOP) approaches to the language model (LM) adaptation that require the optimization of a number of competing objectives. In LM adaptation, an adapted LM is found so that it is as close as possible to two independently trained LMs. The LM adaptation approach developed in this paper is based on reformulating the training objective of a maximum a posteriori (MAP) method as an MOP problem. We extract the individual at least partially conflicting objective functions, which yields a problem with four objectives for a bigram LM: The first two objectives are concerned with the best fit to the adaptation data while the remaining two objectives are concerned with the best prior information obtained from a general domain corpus. Solving this problem in an iterative manner such that each objective is optimized one after another with constraints on the rest, we obtain a target LM that is a log-linear interpolation of the component LMs. The LM weights are found such that all the (at least partially conflicting) objectives are optimized simultaneously. We compare the performance of the SOP- and MOP-based solutions. Our experimental results demonstrate that the ICO method achieves a better balance among the design objectives. Furthermore, the ICO method gives an improved system performance.     

Board’s IQ: What makes a board smart?

The amount of investment that has been made in interactive whiteboards (IWB) in the Turkish educational system during the past several years is quite striking. This investment is part of a plan to integrate information and communication technologies (ICT) into the Turkish educational system, with the goal of increasing the qualitative and quantitative aspects of schooling. Prior to IWB investments, hundreds of thousands of computers, projectors, and printers were distributed to schools in efforts to raise a generation able to respond to the demands of the 21st century. In addition, 98% of secondary school students and 93% of primary school students were provided with Internet access via ADSL. The aim of this study is to analyze the emerging trend of smart board investment in Turkish primary and secondary schools, with consideration of problems that hinder the effective use of IWBs in classrooms as compared to previous ICT integration efforts by the Ministry of National Education. The research is designed as an evaluative case study. The required data are collected through online questionnaires, teacher and pupil interviews, and document searches from teachers and students from various Turkish primary and secondary schools. It is not surprising that the factors hindering the use of IWBs in education are similar to the inhibiting factors in previous ICT integration projects. The findings show that when the needs for in-service training, digital education materials, support, maintenance, and administration are not addressed, educational ICT is unlikely to deliver the expected results.     

Using Modified Bellani Plate Evapotranspiration Gauges to Estimate Short Canopy Reference Evapotranspiration

Modified Bellani plate atmometer has been offered as an alternative and simpler technique to combination-based equations to estimate evapotranspiration (ET) rate from green grass surface. However, there is a lack of information on its’ accuracy in humid climates. The evaporation rate (EA) from one type of atmometer marketed under the brand name ETgage? (or ETG) with a Number 30 green canvas cover that simulates the ET rate from a green grass surface was tested against the reference ET of a short green grass canopy (ETo) computed using the Food and Agriculture Organization of the United Nations Paper No. 56 Penman–Monteith (FAO56-PM) equation in two sites in north-central Florida. The ETG underestimated the ETo as much as 27%. The root mean square error (RMSE) of daily estimates of EA ranged from 1.03 to 1.15?mm. Data analyses indicated that the most of the poor performances and underestimations of the ETG occurred on rainy days. Using only the nonrainy day EA versus ETo relationship, the daily RMSE was as low as 0.47?mm and r2 was as high as 0.89, and the underestimations were within 3% of the ETo. Averaging daily ETG readings over 3 and 7 day periods considerably improved (lower RMSE and percent error, %E, and higher r2) ETo estimates. The ETG performed quite well on nonrainy days. The adjustment factors were developed and tabulated as a function of rainfall amount to adjust the EA values on rainy days. Results showed that an average adjustment factor of 0.84?(EA/0.84 = ETo) can be used as a practical number if rainfall observations are not available. The underestimations of the ETG on rainy days were attributed, in part, to the wetting of the green canvas cover due to the rainwater accumulations on it and to the lower diffusivity (higher resistance) value of the canvas cover (112–294?s?m?1) compared to the diffusivity of a green grass surface used in the ETo definition (70?s?m?1). Although it is found that the ETG is feasible and practical device, the EA values measured on rainy days require careful interpretation in humid and rainy climates such as Florida. The rainy day EA values should be used cautiously with the proper regression equation and adjustment factors to estimate ETo for irrigation scheduling if the input variables are not available to use the FAO56-PM equation for ETo estimates.     

Biosorption potential of Neurospora crassa cells for decolorization of Acid Red 57 (AR57) dye

Biosorption of Acid Red 57 (AR57) on to Neurospora crassa was studied with variation of pH, contact time, biosorbent and dye concentrations and temperature to determine equilibrium and kinetic models. The AR57 biosorption was fast and equilibrium was attained within 40 min. Langmuir, Freundlich and Dubinin–Radushkevich (D–R) isotherm models were applied to experimental equilibrium data for AR57 biosorption at various temperatures. The equilibrium data fitted very well to all the equilibrium models in the studied concentration range of AR57. Maximum biosorption capacity (q_max) of AR57 on to N. crassa was 2.16 × 10^?4 mol g^?1 at 20 °C. The kinetics of biosorption of AR57 were analyzed and rate constants were derived. The overall biosorption process was best described by a pseudo‐second‐order kinetic model. The changes in Gibbs free energy, enthalpy and entropy of biosorption were also evaluated for the biosorption of AR57 on to N. crassa. The results indicate that the biosorption was spontaneous and exothermic in nature. Copyright © 2006 Society of Chemical Industry     

Nonlinear optical absorption of ZnO doped with copper nanoparticles in the picosecond and nanosecond pulse laser field

The nonlinear absorption of nanocomposite layers based on ZnO implanted with Cu+ ions with an energy of 160 keV in implantation doses of 10(16) and 10(17) ions/cm2 was investigated. The values of the nonlinear absorption coefficient were measured by the Z-scan method at a wavelength of 532 nm by use of nanosecond and picosecond laser pulses. Possible optical applications of these materials are discussed.     

Determination of the equilibrium, kinetic and thermodynamic parameters of adsorption of copper(II) ions onto seeds of Capsicum annuum

Adsorption of copper ions onto Capsicum annuum (red pepper) seeds was investigated with the variation in the parameters of pH, contact time, adsorbent and copper(II) concentrations and temperature. The nature of the possible adsorbent and metal ion interactions was examined by the FTIR technique. The copper(II) adsorption equilibrium was attained within 60 min. Adsorption of copper(II) ions onto C. annuum seeds followed by the Langmuir, Freundlich and Dubinin-Radushkevich (D-R) isotherm models. Maximum adsorption capacity (q(max)) of copper(II) ions onto red pepper seeds was 4.47x10(-4) molg(-1) at 50 degrees C. Three kinetic models including the pseudo-first-order, pseudo-second-order and intraparticle diffusion equations were selected to follow the adsorption process. Kinetic parameters such as rate constants, equilibrium adsorption capacities and related correlation coefficients, for each kinetic model were calculated and discussed. It was indicated that the adsorption of copper(II) ions onto C. annuum seeds could be described by the pseudo-second-order kinetic model and also followed the intraparticle diffusion model up to 60 min, but diffusion is not only the rate controlling step. Thermodynamics parameters such as the change of free energy, enthalpy and entropy were also evaluated for the adsorption of copper(II) ions onto C. annuum seeds.     

Sensitivity Analyses and Sensitivity Coefficients of Standardized Daily ASCE-Penman-Monteith Equation

The sensitivity of the standardized ASCE grass-reference Penman-Monteith evapotranspiration (ASCE-PM ETo) equation to climate variables in different regions has not yet been studied. Sensitivity analyses for the standardized daily form of the ASCE-PM equation were conducted on wind speed at 2?m height (U2), maximum and minimum air temperatures (Tmax and Tmin), vapor pressure deficit (VPD), and solar radiation (Rs) in the following regions of the United States: semiarid (Scottsbluff, Nebraska, and Bushland, Texas), a Mediterranean-type climate (Santa Barbara, California), coastal humid (Fort Pierce, Florida), inland humid and semihumid (Rockport, Missouri, and Clay Center, Nebraska), and an island (Twitchell Island, California). The sensitivity coefficients were derived for each variable on a daily basis. In general, ETo was most sensitive to VPD at all locations, while sensitivity of ETo to the same variable showed significant variation from one location to another and at the same location within the year. After VPD, ETo was most sensitive to U2 in semiarid regions (Scottsbluff, Clay Center, and Bushland) during the summer months. The Rs was the dominant driving force of ETo at humid locations (Fort Pierce and Rockport) during the summer months. At Santa Barbara, the sensitivity of ETo to U2 was minimal during the summer months. At Bushland, Scottsbluff, and Twitchell Island, ETo was more sensitive to Tmax than Rs in summer months, whereas it was equally sensitive to Tmax and Rs at Clay Center. The ETo was not sensitive to Tmin at any of the locations. The change in ETo was linearly related to change in climate variables (with r2 ≥ 0.96 in most cases), with the exception of Tmin, at all sites. Increase in ETo with respect to increase in climate variable changed considerably by month. On an annual average, a 1°C increase in Tmax resulted in 0.11, 0.06, 0.16, 0.07, 0.11, 0.08, and 0.10?mm increases in ETo at Scottsbluff, Santa Barbara, Bushland, Fort Pierce, Twitchell Island, Rockport, and Clay Center. A 1?m?s?1 increase in U2 resulted in 0.42, 0.18, 0.37, 0.28, 0.31, 0.20, and 0.26?mm increases in ETo at the same locations. A unit increase in Tmax resulted in the largest increase in ETo at Bushland, and a unit increase in Rs caused the largest increases in ETo at Fort Pierce. A 1?MJ?m?2?d?1 increase in Rs resulted in 0.05, 0.08, 0.06, 0.11, 0.05, 0.06, and 0.06?mm increases in ETo at the same locations. A 0.4?kPa increase in VPD resulted in 1.13, 0.54, 1.29, 0.57, 1.04, 1.10, and 1.22?mm increases in ETo at the same locations. The U2 had the most effect on ETo at Scottsbluff and Bushland, the two locations where dry and strong winds are common during the growing season. The sensitivity coefficient for Rs was higher during the summer months and lower during the winter months, and the opposite was observed for VPD (except for Twitchell Island). The decrease of the sensitivity coefficients for Rs corresponding to an increase in the sensitivity coefficient for VPD is due to a decrease in the energy term in favor of the increase in significance of the aerodynamic term of the standardized ASCE-PM equation in summer versus winter months. Because the ASCE-PM and the Food and Agriculture Organization paper number 56 Penman-Monteith (FAO56-PM) equations are identical when applied on a daily time step, the results of the sensitivity analyses and sensitivity coefficients of this study should be directly applicable to the FAO56-PM equation.