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101.
Amir Mohammadzadeh Pter P. Lakatos Mihly Balogh Ferenc Zdor Dvid rpd Kardi Zoltn S. Zdori Kornl Kirly Anna Rita Galambos Szilvia Barsi Pl Riba Sndor Benyhe Lszl Kles Tams Tbi va Szk Laszlo G. Harsing Jr. Mahmoud Al-Khrasani 《International journal of molecular sciences》2021,22(5)
The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP. 相似文献
102.
This paper aims to provide a systematic and comprehensive survey of state-of-the-art machine learning techniques and their potential applications in IoT-integrated power systems. 相似文献
103.
Short-term load forecasting is of great significance to the secure and efficient operation of power systems. However, loads can be affected by a variety of external impact factors and thus involve high levels of uncertainties. So it is a challenging task to achieve an accurate load forecast. This paper discusses three commonly-used machine-learning methods used for load forecasting, i.e., the support vector machine method, the random forest regression method, and the long short-term memory neural network method. The features and applications of these methods are analyzed and compared. By integrating the advantages of these methods, a fusion forecasting approach and a data preprocessing technique are proposed for improving the forecasting accuracy. A comparative study based on real load data is performed to verify that the proposed approach is capable of achieving a relatively higher forecasting accuracy. 相似文献
104.
Mohammadi Hossein Mohammadi Mohammad Amiri Iraj Sadegh Hosseinghadiry Mahdiar 《SILICON》2021,13(3):747-755
Silicon - In this paper, a new structure: triple work function metal gate SOI MESFET, intended for integration into the deep-submicron CMOS technology, is proposed. The gate of the device consists... 相似文献
105.
Barimani Samaneh Amini Amir Chaharmahali Iman 《Journal of Computational Electronics》2021,20(3):1332-1342
Wave absorbers are considered to be fundamental building blocks for the manipulation of light. Almost all optical systems exploit absorbers to realize some functions. A highly tunable wide-band THz absorber is presented herein. Utilizing a dual-bias scheme with a single graphene layer leads to greater freedom to control the absorption response, while a conventional periodic array of graphene ribbons and a layer of graphene sheet are also exploited. Also, a circuit model representation for all the constituent parts of the proposed absorber is developed with an evolved design methodology. According to the simulation results, wide-band absorption from 3.5 to 6 THz is achieved.
相似文献106.
The hydrodynamics and mass transfer characteristics of a lab-scale jet bubbling reactor(JBR) including the gas holdup, volumetric mass transfer coefficient and specific interfacial area were assessed experimentally investigating the influence of temperature, p H and superficial gas velocity. The reactor diameter and height were 11 and 30 cm,respectively. It was equipped with a single sparger, operating at atmospheric pressure, 20 and 40℃, and two p H values of 3 and 6. The height of the liquid was 23 cm, while the superficial gas velocity changed within 0.010–0.040 m·s~(-1) range. Experiments were conducted with pure oxygen as the gas phase and saturated lime solution as the liquid phase. The liquid-side volumetric mass transfer coefficient was determined under unsteady-state oxygen absorption in a saturated lime solution. The gas holdup was calculated based on the liquid height change, while the specific interfacial area was obtained by a physical method based on the bubble size distribution(BSD) in different superficial gas velocities. The results indicated that at the same temperature but different p H, the gas holdup variation was negligible, while the liquid-side volumetric mass transfer coefficient at the p H value of 6 was higher than that at the p H = 3. At a constant p H but different temperatures, the gas holdup and the liquid-side volumetric mass transfer coefficients at 40℃ were higher than that of the same at 20℃. A reasonable and appropriate estimation of the liquid-side volumetric mass transfer coefficient(kla) in a pilot-scale JBR was provided which can be applied to the design and scale-up of JBRs. 相似文献
107.
Kevin Munoz Samiksha Wasnik Amir Abdipour Hongzheng Bi Sean M. Wilson Xiaolei Tang Mahdis Ghahramanpouri David J. Baylink 《International journal of molecular sciences》2021,22(10)
Acute lung injury (ALI) afflicts approximately 200,000 patients annually and has a 40% mortality rate. The COVID-19 pandemic has massively increased the rate of ALI incidence. The pathogenesis of ALI involves tissue damage from invading microbes and, in severe cases, the overexpression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This study aimed to develop a therapy to normalize the excess production of inflammatory cytokines and promote tissue repair in the lipopolysaccharide (LPS)-induced ALI. Based on our previous studies, we tested the insulin-like growth factor I (IGF-I) and BTP-2 therapies. IGF-I was selected, because we and others have shown that elevated inflammatory cytokines suppress the expression of growth hormone receptors in the liver, leading to a decrease in the circulating IGF-I. IGF-I is a growth factor that increases vascular protection, enhances tissue repair, and decreases pro-inflammatory cytokines. It is also required to produce anti-inflammatory 1,25-dihydroxyvitamin D. BTP-2, an inhibitor of cytosolic calcium, was used to suppress the LPS-induced increase in cytosolic calcium, which otherwise leads to an increase in proinflammatory cytokines. We showed that LPS increased the expression of the primary inflammatory mediators such as toll like receptor-4 (TLR-4), IL-1β, interleukin-17 (IL-17), TNF-α, and interferon-γ (IFN-γ), which were normalized by the IGF-I + BTP-2 dual therapy in the lungs, along with improved vascular gene expression markers. The histologic lung injury score was markedly elevated by LPS and reduced to normal by the combination therapy. In conclusion, the LPS-induced increases in inflammatory cytokines, vascular injuries, and lung injuries were all improved by IGF-I + BTP-2 combination therapy. 相似文献
108.
Jagtar Singh Mohammad Farooq Wani 《International Journal of Applied Ceramic Technology》2021,18(5):1853-1862
Tribological properties of Ti3SiC2 ceramic and Ti3SiC2/GNP composite were investigated using fretting sliding against Si3N4 ball counter body at a load of 50 N for a sliding distance of 900 m, under non-textured lubricated (NTL), textured lubricated (TL) condition, and textured lubricated high temperature (TLHT). This paper presents the influence of laser surface texturing (LST) on Ti3SiC2 and its graphene nanoplatelets (GNP) reinforced composite established through spark plasma sintering (SPS), tested under fretting wear conditions. The coefficient of friction and wear rate of Ti3SiC2 and its graphene nanoplatelets reinforced composites were incontrovertibly enhanced with laser surface texturing as compared to non-textured Ti3SiC2 and its GNP composite. The TL surface of Ti3SiC2 composite reinforced with 15% GNP showed the lowest COF and wear rate. Almost negligible changes were observed for TLHT tests. The LST proved to an efficient technique for enhancing the friction and wear properties of Ti3SiC2 and Ti3SiC2/GNP composite. 相似文献
109.
Ali Kargar nigje Esmaeil Salimi Mohammad Jafar Molaei Mojtaba Ghatee 《International Journal of Applied Ceramic Technology》2021,18(6):1921-1929
This study reported the synthesis of fluorescent hydroxyapatite/alginate/carbon quantum dots (HA/Alg/CQDs) nanocomposites via the co-precipitation technique. The N-doped CQDs as a new class of fluorescent materials were prepared by the citric acid pyrolysis method, with an average size around 4 nm. Physical, chemical, and optical properties of the synthesized nanocomposites were investigated by X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), atomic force microscopy (AFM), field-emission scanning electron microscopy (FESEM), UV–visible spectroscopy, and photoluminescence (PL) spectroscopy, respectively. The PL spectroscopy data verified the favorable in vitro luminescent emission of the HA/Alg/CQDs nanocomposites in comparison with HA/Alg and HA samples. The XRD patterns of the prepared samples confirmed the formation of crystalline HA in all composites, possessing a Ca/P ratio around 1.5 as obtained by EDX elemental analysis. The FESEM analysis exhibited HA nanoplates that homogeneously distributed throughout the alginate matrix. Therefore, the synthesized nanocomposites could be regarded as potential trackable drug carriers for hard tissue engineering applications. 相似文献
110.
Rouhollah Jalili Mohammad Morshed Seyed Abdolkarim Hosseini Ravandi 《应用聚合物科学杂志》2006,101(6):4350-4357
Electrospinning with a collector consisting of two pieces of electrically conductive substrates separated by a gap has been used to prepare uniaxially aligned PAN nanofibers. Solution of 15 wt % of PAN/DMF was used tentatively for electrospinning. The effects of width of the gap and applied voltage on degree of alignment were investigated using image‐processing technique by Fourier power spectrum method. The electrospinning conditions that gave the best alignment of nanofibers for 10–15 wt % solution concentrations were experimentally obtained. Bundles like multifilament yarns of uniaxially aligned nanofibers were prepared using a new simple method. After‐treatments of these bundles were carried out in boiling water under tension. A comparison was made between the crystallinity and mechanical behavior of posttreated and untreated bundles. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 4350–4357, 2006 相似文献